Journal of Osteology and Arthritis (JOA)

Editor In Chief: Wei ZhangMD, PhD


Center of Emphasis in Infectious Diseases
Texas Tech University Health Sciences Center
Address:USA
Biography

Dr. Wei Zhang obtained his Bachelor of Medicine from China Medical University, Master and MD/Ph.D in immunology from Beijing Institute of Basic Medical Sciences, followed by a postdoctoral fellowship in Japan Science and Technology Agency (JST) at Tokai University (Hiratsuka, Kanagawa, Japan). He has published over 40 scientific articles, including 10 publications as the first or corresponding author in high-quality international peer-reviewed journals. Dr. Wei Zhang serves on the review panel and editorial board of 11 journals including Journal of Cellular Biochemistry, Drug Design, Development and Therapy, Scandinavian Journal of Rheumatology, Molecular Biology, and Journal of Bioequivalence & Bioavailability. He was awarded the second prize of Beijing scientific and technological progress in 2008 because of the studies of antigen-antibody interaction. He has got four invention patents in China based on those translational medicine researches. 

Research Interests

Cancer and Autoimmune Disease Therapy and Mechanisms; Molecular and Cellular Immunology; Molecular Biology; Antibody Engineering; Recombinant Proteins; Protein-Protein Interaction; Gene Therapy; Animal and Cell Models; Signal Transduction, Apoptosis, and Molecular Mechanisms; Protein Expression, Purification and Function; Genome/Proteome Sciences.

Publications

1. *Zhang W, Zhu J, Du Z, Yu J, Xu Y, Wang F. Intraarticular gene transfer of SPRY2 suppresses adjuvant-induced arthritis in rats. Appl Microbiol Biotechnol, 2015, 99(16):6727-6735.
2. *Zhang W, Du Z, Zhu J, Yu J, Xu Y. Sprouty2 suppresses the inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes through regulating the Raf/ERK and PTEN/AKT signals. Mol Immunol, 2015, 67(2):532-539.
3. *Wang F, Yu J, Wang Y, Jiang Y, Guo N, Zhang W* (corresponding author). Combination therapy with TNFR-Fc and CTLA4-FasL using the recombinant adeno-associated virus potently suppresses adjuvant-induced arthritis in rats. Appl Microbiol Biotechnol, 2015, 99(15):6327-6337.
4. *Wang Y, Zhang L, Zhang W (co-first author), Wu H, Zhu X, Xu Y, Yan J, Yu J. Increasing plasmid-based DNA vaccine construct (16 kb pSVK-HBVA) production in Escherichia coli XL10-Gold through optimization of media component. Biotechnology & Biotechnological Equipment, 2015,
29(1):164-174.
5. Zhang L, Wang Y, Xiao Y, Wang Y, Dong J, Gao K, Gao Y, Wang X, Zhang W, Xu Y, Yan J, Yu J. Enhancement of antitumor immunity using a DNA-based replicon vaccine derived from Semliki Forest virus. PLoS One, 2014, 9(3):e90551.
6. *Zhang W, Wang F, Yan J, Zhang X, Wang Y, Jiang Y, Wang L, Xu Y, Yu J. Design, expression and characterization of a novel coexpression system of two antiarthritic molecules. Appl Microbiol Biotechnol, 2013, 97(14):6301-6314.
7. *Zhang W, Wang F, Wang B, Zhang J, Yu JY. Intraarticular gene delivery of CTLA4-FasL suppresses experimental arthritis. Int Immunol, 2012, 24(6):379-388.
8. *Zhang W, Wang B, Wang F, Zhang J, Yu J. CTLA4-FasL fusion product suppresses proliferation of fibroblast-like synoviocytes and progression of adjuvant-induced arthritis in rats. Mol Immunol, 2012, 50(3):150-159.
9. Yuasa N, Zhang W, Goto T, Sakaue H, Matsumoto-Takasaki A, Kimura M, Ohshima H, Tsuchida Y, Koizumi T, Sakai K, Kojima T, Yamamoto K, Nakata M, Fujita-Yamaguchi Y. Production of anti-carbohydrate antibodies by phage display technologies: potential impairment of cell growth as a result of endogenous expression. J Biol Chem, 2010, 285(40):30587-30597.
10. Yan J, Jia R, Song H, Liu Y, Zhang L, Zhang W, Wang Y, Zhu Y, Yu J. A promising new approach of VEGFR2-based DNA vaccine for tumor immunotherapy. Immunol Lett, 2009, 126(1-2):60-66. 11. *Zhang W, Matsumoto-Takasaki A, Kusada Y, Sakaue H, Sakai K, Nakata M, Fujita-Yamaguchi Y. Isolation and Characterization of Phage-Displayed Single Chain Antibodies Recognizing Nonreducing Terminal Mannose Residues. 2. Expression, Purification, and Characterization of Recombinant Single Chain Antibodies. Biochemistry, 2007, 46(1):263-270.
12. Yuasa N, Iida N, Sakaue H, Zhang W, Wilczynski S, Fujita-Yamaguchi Y. Construction of a recombinant single chain antibody recognizing nonreducing terminal mannose residues applicable to immunohistochemistry. Biosci Trends, 2007, 1(2):108-112.
13. Sakai K, Shimizu Y, Chiba T, Matsumoto-Takasaki A, Kusada Y, Zhang W, Nakata M, Kojima N, Toma K, Takayanagi A, Shimizu N, Fujita-Yamaguchi Y. Isolation and characterization of phage-displayed single chain antibodies recognizing nonreducing terminal mannose residues. 1. A new strategy for generation of anti-carbohydrate antibodies. Biochemistry, 2007, 46(1):253-262.
14. Zhu C, Liu X, Feng J, Zhang W, Shen B, Ou'yang W, Cao Y, Jin B.
Characterization of the neutralizing activity of three anti-human TNF monoclonal antibodies and prediction of their TNF epitopes by molecular modeling and mutant protein approach. Immunol Lett, 2006, 102(2):177-183.
15. *Zhang W, Feng J, Li Y, Guo N, Shen B. Humanization of an anti-human TNF-α antibody by variable region resurfacing with the aid of molecular modeling. Mol Immunol, 2005, 42(12):1445-1451.
16. Feng J, Li Y, Zhang W, Shen B. Rational design of potent mimic peptide derived from monoclonal antibody: antibody mimic design. Immunol Lett, 2005, 98(2):311-316.
17. *Zhang W, Feng J, Shen B. Identification of binding epitope of a monoclonal antibody (Z12) against human TNF-α using computer modeling and deletion mutant technique. Sci China C Life Sci, 2004, 47(3):279-286.
18. Liu Y, Zhang W, Yu X, Zhang H, Zhao R, Shangguan D, Li Y, Shen B, Liu G. Quartz crystal biosensor for real-time kinetic analysis of interaction between human TNF-α and monoclonal antibodies. Sensors and Actuators B: Chemical, 2004, 99(2-3):416-424.
19. Qin W, Feng J, Zhang W, Li Y, Shen B. A novel TNFalpha antagonizing peptide-Fc fusion protein designed based on CDRs of TNFalpha neutralizing monoclonal antibody. Biochem Biophys Res Commun, 2004, 322(3):1024-1028.

Scientific Activities

Sevdalina LambovaPhD

Assistant Professor
Department of Propedeutics in Internal Medicine
Medical University – Plovdiv
Address:Bulgaria
Biography

Dr Sedalina Lambova is a specialist in Rheumatology with a PhD degree in Rheumatology. She has graduated in medicine with honours in Trakia University, Medical faculty, Stara Zagora, Bulgaria in 2003. In 2004, Dr Lambova has started her education as a PhD student in
Rheumatology in the Department of Propedeutics of Internal medicine, Clinic of Rheumatology, Medical University, Plovdiv, Bulgaria. Since 2007 until present, dr Lambova is an Assistant Professor in Rheumatology and Internal medicine in the Department for Propedeutics of Internal medicine, Clinic of Rheumatology, Medical University, Plovdiv, Bulgaria. She has undergone training in Internal Medicine and Rheumatology. In 2009, dr S.
Lambova has undergone education and performed research in Justus Liebig University - Giessen, Department of Internal Medicine and Rheumatology and in December 2011 she defended a dissertation focused on “The role of capillaroscopy in rheumatology” under the guidance of Prof dr Ulf Müller-Ladner. In 2014, dr Lambova receives Master degree in Health Management. Her scientific interests are focused on the role of capillaroscopy in Rheumatology, microvascular involvement in rheumatic diseases, new insights in pathogenesis and treatment of Raynaud’s phenomenon and systemic sclerosis, new developments in diagnosis and treatment of inflammatory arthritis, connective tissue diseases and osteoarthritis. Dr Sevdalina Lambova is an author and co-author in a number of scientific publication in Bulgaria and abroad, reviewer in international rheumatological editions in the field of her scientific interests.

Research Interests

The role of capillaroscopy in Rheumatology, microvascular involvement in rheumatic diseases, new insights in
pathogenesis and treatment of Raynaud’s phenomenon and systemic sclerosis, new developments in diagnosis and treatment of inflammatory arthritis, connective tissue diseases and osteoarthritis.

Publications

1. Lambova S. Cardiac manifestations in systemic sclerosis. World J Cardiol. 2014;6(9):993-
1005.
2. Putrik P, Ramiro S, Kvien TK, Sokka T, Pavlova M, Uhlig T, Boonen A; Tafaj A,
Harutyunyan R, Radner H, Soroka N, Mielants H, Sokolovic S, Lambova S et al. Inequities in
access to biologic and synthetic DMARDs across 46 European countries. Ann Rheum Dis.
2014;73(1):198-206.
3. Lambova S, Müller-Ladner U. Feet nailfold capillaroscopy is not useful to detect the typical
scleroderma pattern. Clin Exp Rheumatol. 2013;31(2 Suppl 76):189-90.
4. Lambova S., Müller-Ladner U. Capillaroscopic pattern in systemic lupus erythematosus and
undifferentiated connective tissue disease – what we still have to learn? Rheumatol Int. 2013
Mar;33(3):689-95.
5. Lambova S., Müller-Ladner U. Vascular damage in systemic sclerosis. Curr Rheumatol Rev
2013; 9(4):233-6.
6. Lambova S., Hermann W., Müller-Ladner U. Nailfold capillaroscopy – its role in diagnosis
and differential diagnosis of microvascular damage in systemic sclerosis. Curr Rheumatol Rev
2013; 9(4):254-60.
7. Lambova S., Batalov A., Sapundzhiev L., Müller-Ladner U. Digital ulcers in systemic
sclerosis-frequency, subtype distribution and clinical outcome. Curr Rheumatol Rev 2013;
9(4):268-73.
8. Lambova S., Batalov A., Dobrev H., Sapundzhiev L., Müller-Ladner U. Digital ulcers in
systemic sclerosis-how to manage in 2013? Curr Rheumatol Rev 2013; 9(4):274-8.
9. Lambova S., Müller-Ladner U. The place of nailfold capillaroscopy in the diagnostic algorithm
of inflammatory arthritis. Microvasc Res. 2012; 83(3):318-22.
10. Lambova S, Müller-Ladner U. Connective tissue diseases: Treatment of digital ulcers in
systemic sclerosis. Nat Rev Rheumatol. 2011;7(1):5-6.

11. Lambova S, Hermann W, Müller-Ladner U. Capillaroscopic pattern at the toes of systemic
sclerosis patients: does it "tell" more than those of fingers? J Clin Rheumatol. 2011;17(6):311-4.
12. Lambova S, Müller-Ladner U. Capillaroscopic pattern in paraneoplastic Raynaud's
phenomenon. Rheumatol Int. 2013 Jun;33(6):1597-9.
13. Lambova S, Hermann W, Müller-Ladner U. Comparison of qualitative and quantitative
analysis of capillaroscopic findings in patients with rheumatic diseases. Rheumatol Int. 2012
Dec;32(12):3729-35.
14. Lambova S, Müller-Ladner U.Capillaroscopic findings in systemic sclerosis -- Are they
associated with disease duration and presence of digital ulcers? Discov Med 2011
Nov;12(66):413-8.
15. Lambova S., Müller-Ladner U. Capillaroscopic pattern in systemic sclerosis – an association
with processes of angiogenesis and vasculogenesis. Microvasc Res 2010; 80(3):534-9.
16. Lambova S., Müller-Ladner U. Pulmonary hypertension in systemic sclerosis. Autoimmune
Rev 2010;9(11):761-70.
17. Lambova S., Müller-Ladner U. New lines in therapy of Raynaud’s phenomenon. Rheumatol
Int, 2009; 29(4):355-63.

18. Lambova S., Müller-Ladner U. The specificity of capillaroscopic pattern in connective autoimmune diseases. A comparison with microvascular changes in diseases of social importance: arterial hypertension and diabetes mellitus. Mod Rheumatol. 2009; 19(6):600-5.
19. Lambova S., Müller-Ladner U. The role of capillaroscopy in differentiation of primary and secondary Raynaud's phenomenon in rheumatic diseases: a review of the literature and two case reports. Rheumatol Int. 2009; 29(11):1263-71.

Scientific Activities

Sudipta Chakraborty

Assistant Professor

Homi Bhabha National Institute
Address:India
Biography
Research Interests
  1. Radiopharmaceutical Chemistry,
  2. Production and separation of radioisotopes for medical use,
  3. Design, synthesis and evaluation of radiolabeled molecules for radiopharmaceutical application.
Publications
Scientific Activities

Aleksandra Tomic Lu?i?PhD

Associate Professor
Department of Internal medicine
University of Kragujevac
Address:Serbia
Biography

Aleksandra Tomic Lucic was born in Sarajevo 18.5.1968, where she finished elementary and high school. She graduated on Medical Faculty in Belgrade  21.1.1993. She was employed as Training Assistant at the Department of Physiology on the Faculty of Medicine, University of Kragujevac, Serbia (1994-1998).

She graduated with Master's thesis: "Glucagon  influence on the reactive hyperemia in isolated rat heart" at the Faculty of Medicine in Kragujevac 1998. After that, she was Assistant at the Department of Physiology on the Faculty of Medicine, University of Kragujevac (1998-2010).

She became specialist of Internal medicine on the Faculty of Medicine, University of Belgrade 2001. She worked on the Department of Rheumatology of the Clinical Center Kragujevac, as specialist of Internal medicine (2001-2012).

Aleksandra graduated PhD thesis on Faculty of Medicine, University of Kragujevac, 2010, and also finished subspecialization in Rheumatology on Faculty of Medicine, University of Belgrade with thesis 2011.

Aleksandra Tomic Lucic became Assistant professor on Department of Internal medicine, Faculty of Medicine, University of Kragujevac (2010-2014), and after that Associate professor on the same department (2014-present).

Aleksandra Tomic Lucic became Head of Internal Clinic of the Clinical Center Kragujevac (2012-present). 

Research Interests

Rheumatology, Osteology, Arthritis

Publications
Scientific Activities

Haidar NadrianPhD

Assistant Professor
Health Education and Promotion
Islamic Azad University
Address:Iran
Biography

Haidar Nadrian was born in Sanandaj, Kurdistan Province, Iran in 1978. He finished elementary and high school in Sanandaj. In 2003, he graduated as a B.S. in Public Health from Kerman University of Medical Sciences. Iran. Then, he continued his education in M.Sc. in Heath Education in Yazd University of Medical Sciences. His thesis in this degree was related to quality of life and educational planning for Rheumatoid Arthritis patients.  In 2009, he started his Ph.D. degree education in Tehran University of Medical Sciences. His field of study was Health Education and Promotion. Now, he is a faculty member and dean of School of Nursing and Midwifery, Islamic Azad University-Sanandaj, Iran. His scientific interests are Behavior Change in Non-communicable Diseases (e.g. Self-care in Arthritic Diseases, Cancer Prevention, and Injuries), Health Education and Promotion Models and Theories (especially PRECEDE_PROCEED Model), Health Education and Promotion Planning.

Research Interests

Behavior Change in Non-communicable Diseases (e.g. Self-care in Arthritic Diseases, Cancer Prevention, and Injuries), Health Education and Promotion Models and Theories (especially PRECEDE_PROCEED Model), Health Education and Promotion Planning.

Publications
Scientific Activities

Catherine Baugé PhD

Associate Professor
Cellular Microenvironment and Disease (MILPAT)
University of Caen Lower Normandy
Address:France
Biography

After a master obtained in 2003, I did a PhD at the University of Caen (France). My work consisted to study the interconnection between IL-1b pathway and TGFb signaling and response in aging and OA chondrocytes. In 2006, I became a lecturer and studied the role of hypoxia in chondrogenesis and its interest for tissue engineering applied to cartilage. Then, I did a post-doc at National Institute of Health (USA) before obtaining a position of associated professor in 2009. 

Research Interests

My interest area is rheumatology. I study the physiology of normal and pathological cartilage cells (chondrogenesis, osteoarthritis, chondrosarcoma).

Publications
Scientific Activities

Agnieszka Paradowska-Gorycka PhD

Assistant Professor
Biochemistry and Molecular Biology
Institute of Rheumatology
Address:Poland
Biography

Agnieszka Paradowska-Gorycka  graduated from the Agricultural University of Poznan, Poland. I completed a degree in Biotechnology with specialization in molecular diagnostics. Master's thesis I performed at the Institute of Human Genetics, Polish Academy of Sciences in Poznan, Poland. During my studies I worked for 1.5 years (01.2004 - 07.2005), as a volunteer in the Department of Rheumatology and Clinical Immunology, University of Medical Sciences in Poznan, Poland. After graduation, I took half-year (07.2005 - 12.2005) internship at the Institute of Human Genetics in Leipzig, Germany. In January 2006, I started working in the Department of Biochemistry and Molecular Biology, Institute of Rheumatology, where I work today. Thanks to the work of the Institute of Rheumatology I had the opportunity to carry out a series of studies to doctoral dissertation, which I defended March 18, 2010 at the Centre Biostructure Medical University of Warsaw. 

Research Interests

Genetic studies

Molecular biology

Rheumatology

Autoimmune diseases

Polymorphisms and mutation

RNA and protein levels

T cells

Transcriptional factors

Cytokines

Angiogenesis

Signaling pathways in immune responses

Inflammation 

Publications
Scientific Activities