Journal of Medicinal Chemistry and Research (JMCR)

Abbas ShafieePhD

Professor
Department of Chemistry
Tehran University of Medical Sciences
Address:Tehran, Iran
Biography

Abbas Shafiee is professor of Medicinal Chemistry in Faculty of Pharmacy and head of Pharmaceutical Sciences Research Center in Tehran University of medicinal Sciences.  Born in Qum, Iran, in 1937, graduated from Tehran University (Dr. of Pharmacy in 1962), M.S. from Columbia University USA 1965 and Ph.D. from Columbia University in Medicinal Chemistry in 1968. His Research interest has been mostly in heterocyclic chemistry, organic reaction mechanism, natural product and mechanism of action of drugs. In recognition of his outstanding research, he was awarded international and national prizes. In addition according to Essential Science Indicators (ESI), he is among the 1% citation scientist in the field of Chemistry and Pharmacology. He is a member of TWAS, and Iranian Academy of Sciences and others. He is guest editor for special issue of EJMC (2014-2015) and editorial board of several Iranian Journals such as JICS, Daru, etc.

Research Interests

Heterocyclic Chemistry, Organic Reaction mechanisms, Steroids, Natural Products, Organic Synthesis, and Mechanism of Action of Drugs.

Publications
Scientific Activities

Tijana Iši? Den?i?


Laboratory for Endocrinology and Radioimmunology
Institute for the Application of Nuclear Energy-INEP
Address:Belgrade, Serbia
Biography
Research Interests

Fundamental studies of biological and genetic markers, diagnosis and prognosis of thyroid carcinomas, alterations in gene expressions during carcinogenesis of thyroid gland.

Publications
Scientific Activities

Stefano GiovagnoliPhD

Professor
Department of Pharmaceutical Sciences
University of Perugia
Address:Italy
Biography

Stefano Giovagnoli graduated in chemistry in 1997 at the University of Perugia. In 2000 he worked at the GlaxoSmithKlein Ware England, in R&D of new injectable forms. In 2001, he started a Ph.D. in Chemistry and Technology of Drugs at the University of Perugia. In 2002, he was engaged at the University of Kentucky, Lexington, Kentucky, in the laboratories of Professor Patrick P. DeLuca, where he conducted part of his doctoral work on microencapsulation and characterization of antipsychotic drugs, in vitro studies and animal models, microencapsulation of proteins and enzymes and their stabilization. In 2004, he completed his Ph.D. studies on micro- and nanoparticulate systems for the delivery of antioxidants and proteins. This work was chosen as a recipient of the 2004 AAPS Outstanding Graduate Student Research Award in Pharmaceutical Technologies by Solvay Pharmaceuticals and the American Association of Pharmaceutical Scientists (AAPS). In 2007-2008 he was visiting postdoc at the School of Pharmacy, University of Kentucky, Lexington, Kentucky, in the laboratories of Professor Patrick DeLuca, where he worked on the formulation of delivery systems for intradermal antischlerotic drugs and buccal fast dissolving films. He is currently Adjunct Professor of Pharmaceutical technology and Biotechnology at the Department of Pharmaceutical Sciences, University of Perugia. His research focuses primarily on the formulation and characterization of respirable powders for the treatment of pulmonary tuberculosis, formulation and characterization of lipid nanoparticles, polymeric and metal nanoparticles for targeting the central nervous system and the development of biomimetic systems for cell therapy. It serves as a referee for several international scientific journals in the field of pharmaceutical technology and as Board Editor of the Journal of Pharmaceutical Innovation. He is member of the American Association of Pharmaceutical Scientists (AAPS), Italian Chemical Society (SCI), AAPS Italian University Network (AItUN), and the Association of Italian Faculties of Pharmaceutical Technology and Regulation (ADRITELF). He has about 90 presentations at congresses, conferences and international meetings, 57 publications in peer-review international scientific journals, a book chapter and a patent.

Research Interests

Research focuses primarily on the formulation and characterization of respirable powders for the treatment of pulmonary tuberculosis, formulation and characterization of lipid nanoparticles, polymeric and metal nanoparticles for targeting the central nervous system and the development of biomimetic systems for cell therapy. 

Publications
Scientific Activities

Hongyuan YanPhD

Professor
College of Pharmaceutical Sciences
Hebei University
Address:China
Biography

Prof. & Dr. Hongyuan Yan, Graduated from Hebei University for his B.S. and M.S degree, and got his Ph. D degree from Inha University of Korea. He is the Director of Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Laboratory of Chromatographic Separation and Pharmaceutical Analysis of Hebei University, and deputy director of Institute of analysis instrument and technology of Hebei Province, China.

His major study involves (1) Separation & purification and quality control of food science; (2) new functional materials for food and pharmaceutical analysis.
He obtained 10 research projects from NSFC, SRF for ROCS and other organizations in recent five years, and published more than 30 papers in various international journals, such as Journal of Chromatography A, Talanta, Analytica Chimica Acta, Journal of Pharmaceutical and Biomedical Analysis, Journal of Separation Science, etc. His paper published in Journal of Pharmaceutical and Biomedical Analysis was awarded the Top Cited Article by Elsevier in the year 2010-2011.

Research Interests

(1) Separation & purification and quality control of food science; (2) new functional materials for food and pharmaceutical analysis.

Publications
Scientific Activities

Mehrorang Ghaedi


Department of Chemistry
Yasouj University
Address:Iran
Biography
Research Interests
  • Solid Phase Extraction Method
  • Liquid-Liquid Extraction
  • Transport of ions thorough liquid membrane
  • Cloud Point extraction
  • Sensor Fabrication
  • Adsorptive Stripping Analysis
  • Cyclic Voltammetry
  • Spectrophotometry In Surfactant Media
  • Trace Analysis
  • Water Treatment
  • HPLC and GC analysis og organic compound following suitable preconcentration
Publications
Scientific Activities

Ao ZhangPhD

Professor
Synthetic Organic & Medicinal Chemistry Laboratory
Chinese Academy of Sciences
Address:China
Biography

Ao Zhang was born in Sichuan, China, in 1969. He received his B.S. degree in Chemistry in 1992 from Sichuan Normal College, now Xihua Normal University. He was awarded the M.S. degree in Organic Chemistry in 1995 from Nankai University. Then, he worked at the Shanghai Institute of Organic Chemistry for 2 years and joined the predoctoral program of the same Institute in 1997 under the supervision of Professor Biao Jiang. After he was awarded the Ph.D. diploma in Organic Chemistry in 2000, he joined Professor Alan P. Kozikowski's Drug Discovery Group at Georgetown University Medical Center as a Postdoctoral Fellow. In 2002, he joined Professor John L. Neumeyer's Medicinal Chemistry Program as a Research Investigator at McLean Hospital, Harvard Medical School. He was promoted to Instructor at Harvard Medical School in 2003 and Assistant Director of the Medicinal Chemistry Program at McLean Hospital in 2004. He was awarded Alfred Pope Young Investigator Award in 2004 and Adam Corneel Young Investigator Award in 2005 from Harvard Medical School. In 2006 he received the Hundred Talent Project award from the Chinese Academy of Sciences, and became the Professor of Medicinal Chemistry at Shanghai Institute of Materia Medica (SIMM). In 2011, he was awarded the Distinguished Young Investigator Award from Chinese Natural Science Foundation. His research interests include the design and synthesis of novel small molecules as structural and functional probes for the diagnosis and treatment of brain disorders and cancer by using the state-of-art medicinal chemistry strategy. He has authored or co-authored over 80 publications and 40 patents. Several drug candidates from his research group are now under preclinical studies.

Research Interests

Research interests include the design and synthesis of novel small molecules as structural and functional probes for the diagnosis and treatment of brain disorders and cancer by using the state-of-art medicinal chemistry strategy. 

Publications
Scientific Activities

Yingjie ZhangPhD


Department of Medicinal Chemistry
Shandong University
Address:P. R. China
Biography

Yingjie Zhang, Ph.D.

Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University.

44 Wenhuaxi Road, Ji’nan, Shandong, 250012, P. R. China

Tel/Fax: +086-531-88382009

E-mail: zhangyingjie@sdu.edu.cn

 

Education and Training (2003.09 - 2015.01):

2003.09 - 2007.06: B.S. in Pharmacy, Shandong University, Ji’nan, China

2007.09 - 2012.06: PhD. in Medicinal Chemistry, Shandong University, Ji’nan, China

2012.07 - 2013.01: Research Associate in Wenfang Xu’ Group, Shandong University, Ji’nan, China

2013.02 - 2015.01: Postdoc. in Pharmacology, Shandong University, Ji’nan, China

 

Research & Professional Experience (2013.02 - Present):

Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University

Young Scientist of 863 Program in Biology and Medical Technology Field.

Teaching Member of National Excellent Open Course?Drug Design?.

Editorial Board Member of Anti-Cancer Agents in Medicinal Chemistry.

 

Main Research Interests:

Rational design, synthesis and biological evaluation of compounds targeting histone deacetylases (HDACs).

 

Projects & Fundings:

  1. National High-tech R&D Program of China, 863 Program (Grant No.2014AA020523), RMB 1140000 yuan, Principal Investigator.
  2. National Natural Science Foundation of China (Grant No.21302111), RMB 250000 yuan, Principal Investigator.
  3. China Postdoctoral Science Special Foundation (Grant No. 2014T70654), RMB 150000 yuan, Principal Investigator.
  4. China Postdoctoral Science Foundation (Grant No.2013M540558), RMB 80000 yuan, Principal Investigator.
  5. Postdoctoral Innovation Project Foundation of Shandong Province (Grant No.201303090), RMB 20000 yuan, Principal Investigator.

 

Publication Summary:

As first author or corresponding author, Yingjie Zhang has published several research papers in Journal of Medicinal Chemistry, the top journal in the field of medicinal chemistry. The recent paper published in Journal of Medicinal Chemistry (2014, 57: 3324-3341) was highlighted by SciBX (Science–Business eXchange) as a weekly news in the field of anticancer therapeutics and was selected by Global Medical Discovery website as a key drug discover article. One research paper was published as the issue cover paper of Chemical Biology & Drug Design.

Research Interests

Rational design, synthesis and biological evaluation of compounds targeting histone deacetylases (HDACs)

Publications
Scientific Activities

Atanas G. AtanasovPhD


Department of Pharmacognosy
University of Vienna
Address:Austria
Biography

Dr. Atanas G. Atanasov´s research focuses on molecular mechanisms of pharmacological action in the context of inflammation and cardiometabolic disease, and natural product-based drug discovery. Since 2008, Dr. Atanasov is a senior researcher at Department of Pharmacognosy, University of Vienna, where he was actively involved in the execution of the Austrian national network “Drugs From Nature Targeting Inflammation” (DNTI), a collaborative research project which has been financed with >3 000 000 Euro from the Austrian Science Fund. In recognition of his overall achievements, Dr. Atanasov has been awarded in 2012 with “Focus of Excellence” fellowship by the Faculty of Life Sciences, University of Vienna. In addition to traditional ways for scientific dissemination (peer reviewed research publications, conference contributions etc.), Dr. Atanasov has been very successful in respect of direct science communication in the Social Media (Klout Score = 78).

Research Interests
  • Molecular mechanisms of pharmacological action.

• Cell signalling and regulatory pathways relevant for inflammation and cardiometabolic disease.

• Discovery and characterisation of novel bioactivities of natural products.

• Use of small molecules as tools for biological systems manipulation and basic research (chemical biology). 

Publications
Scientific Activities

Mohammad AbidPhD

Assistant Professor
Department of Biosciences
Jamia Millia Islamia (A Central University)
Address:India
Biography

Mohammad Abid is currently working as Senior Assistant Professor in the Department of Biosciences, Jamia Millia Islamia (A Central University), New Delhi, INDIA. Earlier he was graduated with Chemistry Hons. in 2000 and post graduated in 2002 with organic chemistry specialization from Aligarh Muslim University. He earned his Ph.D. in Organic and Medicinal Chemistry (Design and Development of antiamoebic agents) in 2005 under the supervision of Prof. Amir Azam, Department of Chemistry, JMI, New Delhi. He worked as a Postdoc Fellow in University Rene Descartes Paris V on synthesis of novel antibacterial agents targeting PDF and MAP enzymes using dual drug strategy under the mentorship of Prof. and Director Isabelle ARTAUD. He has many awards and recognitions to his credit like postgraduate meritorious scholarship, JRF and SRF from CSIR, Young Scientist award by Science and Engineering Research Board (DST). His research interest involves Computer-aided design and subsequent synthesis of drug-like molecules directed against important therapeutic antimicrobial targets, development of new synthetic methods and natural product modifications. He has 18 publications to his credit published in EJMC, BMC, BMCL, and Dalton Trans. 

Research Interests

Computer-aided design and subsequent synthesis of drug-like molecules directed against important therapeutic antimicrobial targets, development of new synthetic methods and natural product modifications.

Publications
Scientific Activities

Isidoro CaraballoPhD

Professor
Department of Pharmacy and Pharmaceutical Technology
University of Seville
Address:Spain
Biography

Isidoro Caraballo

 

Education

 

  • Degree in Pharmacy (Industrial) from the University of Seville 1990. Degree’s Extraordinary Prize
  • Ph.D. in Pharmacy: “Percolation Theory: application to the design and characterisation of Controlled Release Systems”. University of Seville 1994. Ph.D.’s Extraordinary Prize of the University of Seville
  • Specialist in Industrial Pharmacy and Pharmaceutical Technology. Ministry of Education and Science 2002.

 

Position

 

  • Ordinary Professor of Pharmaceutical Technology and Biopharmaceutics. University of Seville. February 2001 to present.
  • Head of the Iberoamerican-Swiss Center for Development of Dosage Forms of the University of Seville. January 2007 to present
  • CEO of Cronofarma SL, Spin-off Company for assessment and development of pharmaceutical formulations. January 2008 to present
  • Associated Professor, Department of Pharmacy and Pharmaceutical Technology. University of Seville, October 1994 to January 2001.
  • Invited Professor, Department of Pharmaceutical Technology. University of Basle (Switzerland). June to September 1995 and May to August 1999.

 

Awards

 

  • Degree’s Extraordinary Prize of the Faculty of Pharmacy of Seville 1991 (best degree of the Faculty of Pharmacy).
  • Mesa Portillo Memorial Graduate Prize. 1991.
  • Ph.D.’s Extraordinary Prize of the University of Seville. 1994 (best Ph.D. on Pharmacy of the University of Seville).
  • Award of the Controlled Release Society (Eurand Award 2001 for Outstanding Novel Research in Oral Drug Delivery). 28th Symposium of the Controlled Release Society, San Diego, California, 26th June 2001.
  • Prizes for Teaching Excellence of the University of Seville, courses 1999-2000, 2001-2002, 2002-2003, 2003-2004, 2004-2005 and 2005-2006.
  • Research Award of the Cuban Academy of Sciences, January 15th 2003
  • Research Prize – Ministry of Public Health of Cuba. Havana, 2003
  • Distinction of the City of Seville for Teaching Excellence 2004
  • 3rd Edition Prizes for Business Initiatives. Technology Transfer Office of the University of Seville. Creation of Technology-Based Enterprises (EBTs). December 4th 2006
  • TRANSFER Award for the transfer of Reseach to the Industry.  Government of Andalusia. Administration for Innovation and Technological Development. Seville. 2007
  • 4th edition of the Business Awards district of Écija (Sevilla)- Nomination of Cronofarma SLL for the Best Business Innovation. Ecija, 2008.
  • Membership of the Swiss Academy of Pharmaceutical Sciences
  • Research Prize of the Ministry of Education of Cuba, December 2008.
  • Research Award of the Cuban Academy of Sciences, Mars 2009
  • Scientific Award of the Iberoamerican Academy of Pharmacy, January 2010.
  • Award to the best presentation in Pharmaceutical Technology. IV Swiss Pharma Science Day. Bern (Switzerland) 2011.

 

Publications

 

Main research fields:

 

  • Design and Optimization of Controlled Release Dosage Forms, applying new statistical tools as Percolation theory. Interesting findings in this field were the influence of the relative particle size on the percolation threshold as well as the behaviour of critical points in hydrophilic matrix systems.
  • Preformulation studies for drugs and excipients (including stability studies). Development of Chromatographic and Conductometric analytical methods. Study of degradation mechanisms.

 

The most important results have been published in more than 90 research papers in different scientific journals including those having a higher impact in the area of pharmaceutics as Pharmaceutical Research, Journal of Controlled Release, European, European Journal of Pharmaceutics and Biopharmaceutics, Journal of Pharmaceutical Sciences, International Journal of Pharmaceutics, etc.

Other results have been published in more than one hundred Proceedings or Communications to Congresses. Furthermore is co-inventor of 2 patents and author of the Book Chapter “Tablet Design” in “Pharmaceutical Manufacturing Handbook: Production and Processes”, Ed.: Shayne Cox Gad. John Wiley & Sons, Inc. © 2008, pp. 977-1051. ISBN: 978-0-470-25958-0

Research Interests
  • Design and Optimization of Controlled Release Dosage Forms, applying new statistical tools as Percolation theory. Interesting findings in this field were the influence of the relative particle size on the percolation threshold as well as the behaviour of critical points in hydrophilic matrix systems.
  • Preformulation studies for drugs and excipients (including stability studies). Development of Chromatographic and Conductometric analytical methods. Study of degradation mechanisms.
Publications
Scientific Activities

Magdi Awadalla Mohamed ElhusseinPhD

Associate Professor
Pharmaceutical Chemistry
University of Khartoum
Address:Sudan
Biography

Dr. Magdi A. Mohamed was born in Eldammar, Sudan in March 06, 1975. He received his B.Pharm. and M.Pharm. degrees from University of Khartoum. As a pharmacy student, Dr. Magdi was awarded 7 prizes from University of Khartoum and other institutions. He moved to Japan to pursue studies leading to Doctor degree. He was conferred the Doctor of Pharmaceutical Sciences in March 2009 from Kyoto University under supervision of Emeritus Professor Kiyoshi Tomioka. Currently, he is an Associate Professor of Pharmaceutical Chemistry at the Faculty of Pharmacy, University of Khartoum, Sudan where teaches pharmaceutical organic chemistry and medicinal chemistry to undergraduate student. In addition, Dr. Magdi has many master and PhD students. His research interest is focused on synthetic medicinal chemistry, drug discovery, and pharmaceutical analysis. Dr. Magdi has published (as of March 2015) 20 scientific articles in peer-reviewed international journals and 4 abstracts in international conferences. Dr. Magdi is a member of the editorial board of Access International Journals (Advances in Pharmacy and Pharmacology). Apart from the academia, Dr. Magdi is effectively participating in different issues related to the pharmacy profession. He was chosen by the WHO/EMRO to act as an assessor for GGM Phase-I assessment of Public Pharmaceutical Sector in The Republic of Sudan. Currently, he is member of GGM Phase-II framework technical committee. Dr. Magdi has recently been elected as a vise-president of the Pharmacy Specialization Board at Sudan Medical Specialization Board.

Research Interests

Synthetic medicinal chemistry, Drug discovery, and Pharmaceutical analysis

1. Isolation and characterization of naturally occurring compounds with endued anti-tumor activities.
2. Drug discovery for neglected diseases.
3. Insilico design of molecules with anti-malarial and anti-leishmanial activities, and AChE inhibitors.
4. Coupling of nucleophilic drugs with DCQ or Ascorbic Acid for development of new spectrophotometric methods of assay.

5. Development of synthetic routes for naturally occurring compounds with endued anti-tumor activity.
6. Total or partial synthesis of biologically important molecules.
7. Synthesis and biological screening of molecules with hydroxamic acid functionality.
8. Oxidation of secondary amines to amides.

Publications
Scientific Activities

Chi-Rei Wu


Department of Chinese Pharmaceutical Sciences
China Medical University
Address:China
Biography
Research Interests

Neurodegeneration, Behavior, Neurotransmitters,
Neuroscience, Inflammation, Medicinal herbs

Publications
Scientific Activities

Marko AnderluhPhD

Associate Professor
Faculty of pharmacy
University of Ljubljana
Address:Croatia
Biography

Personal data:

  • Date and place of birth: 12th January, 1977, Zagreb, Croatia
  • Nationality: Slovenian
  • Marital status: Married, 2 children
  • Language skills: English (fluent), Croatian (fluent), Italian (Fluent), Serbian (fluent), French (conversant)

 

Education:

  • Assoc. Prof. habilitation: 2013
  • Assist. Prof. habilitation: 2008
  • PhD degree: 27/10/2004: Pharmacy, University of Ljubljana, Faculty of Pharmacy (Supervisor: Prof. Dr. Marija Sollner Dolenc). The title: Design and synthesis of integrin receptor modulators.
  • Master degree: 06/09/2000: Master of Pharmacy, University of Ljubljana, Faculty of Pharmacy (Supervisor: Prof. Dr. Marija Sollner Dolenc). The title: The synthesis of benzoxazine fibrinogen receptor antagonists.
  • 1995: Secondary school degree, Grammar school Koper, Slovenia

     

Academic title: Associate Professor

 

Fields of research:

  • Medicinal chemistry – design, synthesis, and biological evaluation of peptidomimetics, glycomimetics, various enzyme inhibitors and receptor modulators, especially in the field of antibacterial drug discovery
  • Synthetic Organic Chemistry – Custom synthesis of active pharmaceutical ingredients
  • Organic analysis – NMR, MS, IR analysis of organic compounds
  • Biological assay design: competitive-binding assays, cell-based assays

 

Employment:

  • 2000 – : University of Ljubljana, Faculty of pharmacy, Chair of Pharmaceutical Chemistry
  • 04/06/2007-18/04/2008: Universita' di Milano, Dipartimento di Chimica Organica e Industriale, Milano, Italy, guest (post-doc) researcher

 

Scientific studies abroad:

  • 2007-2008: Universita' di Milano, Dipartimento di Chimica Organica e Industriale, Milano, Italy, guest (post-doc) researcher in the group of Prof. Dr. Anna Bernardi
  • 2002: University of Karlsruhe; Institut für Organische Chemie; bilateral colaboration with the group of Prof. Dr. Athanassios Giannis, work on in vitro assay for integrin receptor modulators

 

Scientific training at home:

  • 2010: Bruker basic NMR training, Ljubljana, Slovenia
  • 2006: HPLC: Basic techniques; Ljubljana, Slovenia
  • 2005: From genome to recombinant drug, Faculty of pharmacy; Ljubljana, Slovenia
  • 2004: Prof. Oliver Kappe, Short course on Microwave-Assisted Organic Chemistry, Karl Franzens-University, Graz, Austria
  • 2003: Prof. Hugo Kubinyi: Short course on Medicinal Chemistry, Faculty of pharmacy; Ljubljana, Slovenia

 

Track record statement

Organizational and leadership skills

  • 15-27/09/2003: Postgraduate European Radiopharmacy Course, Block 1: Pharmacy, Ljubljana, Slovenia; Member of organising committee.
  • 13-24/09/2004: Postgraduate European Radiopharmacy Course, Block 1: Pharmacy, Ljubljana, Slovenia; Member of organising committee.
  • 11-22/09/2006: Postgraduate European Radiopharmacy Course, Block 1: Pharmacy, Ljubljana, Slovenia; Member of organising committee.
  • 17-21/06/2007: Austrian-German-Hungarian-Italian-Polish-Slovenian 5th Joint Meeting on Medicinal Chemistry, Portorož, Slovenia; Member of organising committee.
  • 13-15/05/2010: Satellite symposium "Mental Disorders", 35. Assembly of SFD, Portorož, Slovenia; Moderator and president of programme committee.
  • 29/9-1/10/2011: 4th BBBB-Bled International Conference on Pharmaceutical Sciences New Trends in Drug Discovery, Delivery Systems and Laboratory Diagnostics. Bled, Slovenia. Member of organising committee.
  • 2013-2014: The leader of the exploratory team/working group: Quality and Visibility of Training in Medicinal Chemistry, a part of the Framework of the European Federation for Medicinal Chemistry.
  • 25/10/2014: The 1st Annual Meeting of Slovenian Medicinal Chemists. The chairman of the mini-symposium.
  • 2015: Frontiers in Medicinal Chemistry, Antwerp, Belgium. Member of International Scientific Committee.
  • 2015: IXth Joint Meeting in Medicinal Chemistry, Athens, Greece. Member of International Organising Committee.
  • 2016: EFMC-ISMC 2016, Manchester, United Kingdom. Member of International Organising Committee.

 

Ability of the project leader to encourage young researchers to the excellent research work

  • The Lead applicant was a supervisor to over 20 thesists from Uniform master’s programme of Pharmacy and Postgraduate study programme of Clinical Biochemistry. One thesis was awarded Faculty Prešeren Prize and one received Krka’s Prize for research achievements.
  • The Lead applicant was the supervisor of one PhD student (finished with the PhD title) and is currently supervising 3 PhD students at doctoral study of Biomedicine, field of Pharmacy.

 

Working in expert commissions at home and abroad

  • 2009:  member of international commission for evaluation of PhD theses "Commissione giudicatrice per l’esame finale del Dottorato di Ricerca in Scienze Chimiche", Universita' di Milano, Dipartimento di Chimica Organica e Industriale, Milano, Italy.
  • 2013-2016: Member of the Executive Committee of the Slovenian Pharmaceutical Society. President of Section for Medicinal Chemistry of the Slovenian Pharmaceutical Society.
  • 2014: External evaluator of the Postdoctoral Fellowship Programme of the University of Vienna:­ INDICAR (Interdisciplinary Cancer Research).

 

Description of current and past research projects

  • The Lead applicant is a member of the program group P1-0208 Pharmaceutical chemistry: design, synthesis and evaluation of substances for a period between 1999-2015. Within this program group he is primarily engaged in the design, synthesis and biological evaluation of antagonists of lectin DC-SIGN as potential antiviral agents.
  • By 2004, the applicant was engaged in the design, synthesis and biological evaluation of integrin receptor antagonists and antithrombotic compounds with dual mechanism of action. In addition to numerous publications, two national patents have been also awarded as a result of the project findings.
  • The applicant was involved in the European project: EUR-Intafar (inhibition of New Targets for Fighting Antibiotic Resistance). Funded by: European Community Sixth Framework Programme (FP6), Contract number (LSHM-CT-2004-512138). He has optimized synthetic route for the preparation of differently substituted benzylidenrhodanines. Based on this route, several substituted benzylidenrhodanines were synthesized and evaluated as potent Mur ligase inhibitors.
  • The applicant is currently involved in the European project: MAREX (Exploring Marine Resources for Bioactive Compounds: From Discovery to Sustainable Production and Industrial Applications). Funded by: European Community 7th Framework Programme (FP7), Project Reference: 245137. Contact person: TAMMELA Päivi.
  • In the years 2009 and 2010 the applicant was a leader of the applied project led by the company Krka, d.d., where the aim was the innovative synthesis of substance vildagliptin. The project was successfully completed, and the invention was patented by an international patent application: ZUPET, Rok et al.SYNTHESIS AND USE OF VILDAGLIPTIN FOR THE PREPARATION OF PHARMACEUTICAL DOSAGE FORMS. Patent: WO/2011/012322, 2010, A2.
  • Bilateral project PROTEUS BI-FR/12-13-PROTEUS-007; Synthesis, radiolabelling and biological characterization of fluorinated benzovesamicol derivatives as potential radioligands for the vesicular acetylcholine transporter, ARRS. Leading researcher: Assoc. Prof. Dr. Marko Anderluh. The applicant explores methods for radiofluorination of various ligands as markers for positron emission tomography. Work is ongoing in collaboration with Assist. Prof. Dr. Sylvie Mavel, Laboratoire de Chimie Thérapeutique the Faculty of Pharmacy in Tours, France (Faculté de pharmacie, Tours, France).

 

Grants:

  • 1994-2000: Recipient of the national Zois scholarship for gifted students
  • 2000-2004: Young researcher postgraduate scholarship from the Ministry of Education, Science and Sport of the Republic of Slovenia

 

Awards:

  • 2009: a "Sve?ana listina mladim visokošolskim u?iteljem", an award given by University of Ljubljana to excellent young academic teachers.
  • 2006: Futurum 2006 award for outstanding Ph.D. thesis of Ad Futura; Scientific and Educational Foundation of the Republic of Slovenia, Public Fund.
  • 2005: 35th Krka Prize for top 5 research achievements in year 2005 (award of Krka pharmaceutical company for young researchers for their outstanding research in chemistry and pharmacy).
Research Interests
  • Medicinal chemistry – design, synthesis, and biological evaluation of peptidomimetics, glycomimetics, various enzyme inhibitors and receptor modulators, especially in the field of antibacterial drug discovery
  • Synthetic Organic Chemistry – Custom synthesis of active pharmaceutical ingredients
  • Organic analysis – NMR, MS, IR analysis of organic compounds
  • Biological assay design: competitive-binding assays, cell-based assays
Publications
Scientific Activities

Peng ZhanPhD

Associate Professor
Department of Medicinal Chemistry
Shandong University
Address:P.R. China
Biography
  • Dr. Peng Zhan was born in 1982 in Ji’nan, Shandong province, China. He obtained his B.S. degree from Shandong University, China, in 2005. Then he earned his M.S. degree and Ph.D in medicinal chemistry from Shandong University under the supervision of Prof. Xinyong Liu in 2008 and 2010, respectively. He is now working as an associate professor in Shandong University. In 2012, he was appointed as a JSPS Postdoctoral Fellow in Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan under the guidance of Professor Takayoshi Suzuki.
  • His research area involves discovery of novel antiviral, anticancer and neurodegenerative diseases-related agents based on the rational drug design approaches.
  •  So far he has published more than 60 SCI academic peer review papers, more than 10 patents as co-inventors, and received the first prize of Shandong Province Science and Technology Innovation Achievement excellent graduate Award (ranked first) in 2010 and many other honors and awards.
Research Interests

Research area involves discovery of novel antiviral, anticancer and neurodegenerative diseases-related agents based on the rational drug design approaches.

Publications
Scientific Activities

Mahadik Kakasaheb Ramoo

Professor
Pharmaceutical Chemistry
Bharati Vidyapeeth University
Address:India
Biography
Research Interests

Pharmaceutical Analysis, Herbal drug standardization, Phytoformulations and Novel drug delivery systems.

Publications
Scientific Activities