Genetic Disorders and Gene Therapy : Open Access

Editor In Chief: Bhavik P ShahPhD

Senior Scientist
Department of Pfizer

Address:United States
Biography

In 2009, Dr. Bhavik Shah has completed his PhD in Neurobiology from Utah State University. Subsequently, he did post doctoral fellowship from Harvard Medical School. Currently, Dr. Shah is senior scientist in Cardio Vascular and Metabolic Diseases department of Pfizer, Inc.  His research interests are focused understanding genetic and neural basis of obesity.

Research Interests

Functional neural circuits regulating metabolism.
Human genetics of obesity
Understanding genetic and neural basis of obesity

Publications
Scientific Activities

Hui GuoPhD

Research Assistant
Plant Genome Mapping Laboratory
University of Georgia
Address:USA
Biography

Ph.D. in Plant Biology, University of Georgia, USA

M.S. in Biochemistry and Molecular Biology, Sun Yat-sen University, China

B.S. in Biotechnology, South China University of Tropical Agriculture, China

Research Interests

Gene Mapping

Genomics

Publications

Kong WQ, Guo H, Goff VH, Lee TH, Kim C, Paterson AH. (2014) Quantitative trait analysis of branching of recombinant inbred lines for Sorghum bicolor x S. propinquum. Theor Appl Genet. 127:11 2387-2403

Chalhoub B, … Guo H, … et al. (2014) Early allopolyploid evolution in the post-neolithic Brassica napus oilseed genome. Science 345:950-953

Wang X, Jin D, Wang Z, Guo H, Zhang L, Wang L, Li J, Paterson AH. (2014) Telomere-centric genome repatterning determines recurring chromosome number reductions during the evolution of eukaryotes. New Phytologist Epub Aug 20

Guo H, Wang X, Gundlach H, Mayer KFX, Peterson DG, Scheffler BE, Chee PW, Paterson AH (2014) Extensive and biased inter-genomic non-reciprocal DNA exchanges shaped a nascent polyploidy genome, Gossypium (cotton). Genetics 197:1153-1163

Kim C, Lee TH, Guo H, Chung SJ, Paterson AH, Kim DS, Lee GJ. (2014) Sequencing of transcriptomes from two Miscanthus species reveals functional specificity in rhizomes, and clarifies evolutionary relationships. BMC Plant Biology 14.1:134

Liu S, … Guo H, … et al. (2014) The Brassica oleracea genome reveals the asymmetrical evolution of polyploid genomes. Nature Communications 5:3930

Lee TH, Guo H, Wang X, Kim C, Paterson AH. (2014) SNPhylo: a pipeline to construct a phylogenetic tree from huge SNP data. BMC genomics 15:162.

Tang H, Cuevas HE, Das S, Sezen UU, Zhou C, Guo H, Goff VH, Ge Z, Clemente TE, Paterson AH. (2013) Seed shattering in a wild sorghum is conferred by a locus unrelated to domestication. Proc Natl Acad Sci U S A. 110(39): 15824-15829

Wang Z, Zhang D, Wang X, Tan X, Guo H, Paterson AH (2013) A Whole Genome DNA Marker Map for Cotton Based on the D-genome Sequence of Gossypium raimondii L. G3 3(10):1759-1767

Guo H, Lee T, Wang X, Paterson AH (2013) Function Relaxation Followed by Diversifying Selection after Whole-Genome Duplication in Flowering Plants. Plant physiology 162(2):769-778

Zhang D, Guo H, Kim C, Lee T, Li J, Robertson J, Wang X, Wang Z, Paterson AH. (2013) CSGRqtl, a Comparative Quantitative Trait Locus Database for Saccharinae Grasses. Plant physiology 161(2):594-599

Paterson AH, Wendel JF, Gundlach H, Guo H, Jenkins J, Jin D, Llewellyn D, Showmaker KC, Shu S, Udall J et al. (2012) Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres. Nature 492(7429): 423-427

Sato S, … Guo H, … et al. (2012) The tomato genome sequence provides insights into fleshy fruit evolution. Nature 485:635-641

Wang Y, Tang H, DeBarry JD, Tan X, Li J, Wang X, Lee T, Jin H, Marler B, Guo H et al. (2011) MCScanX: a toolkit for detection and evolutionary analysis of gene synteny and collinearity. Nucleic Acids Res. 40(7):e49

Richardson DN, Rogers MF, Labadorf A, Ben-Hur A, Guo H, Paterson AH, Reddy ASN. (2011) Comparative analysis of serine/arginine-rich proteins across 27 eukaryotes: insights into sub-family classification and extent of alternative splicing. PloS One 6(9):e24542

Wang X, … Guo H, … et al. (2011) The genome of the mesopolyploid crop species Brassica rapa. Nature Genetics 43(10):1035-1039

Bao H, Xiong Y, Guo H, Zhou R, Lu X, Yang Z, Zhong Y, Shi S. (2009) MapNext: a software tool for spliced and unspliced alignments and SNP detection of short sequence reads. BMC genomics 10.Suppl 3: S13

Bao H*, Guo H*, Wang J, Zhou R, Lu X, Shi S (2009) MapView: visualization of short reads alignment on a desktop computer. Bioinformatics 25(12):1554-1555 (*co-first author)

Scientific Activities

Mara SimopoulouPhD

Assistant Professor
Department of Obstetrics and Gynecology
University of Athens
Address:Greece
Biography

Mara Simopoulou is an Assistant Professor of Physiology at the Medical School of Athens University and a certified Senior Clinical Embryologist  in the  Assisted Reproduction Unit of “Aretaieion”University Hospital. Having Clinical Embryology-Genetics as her area of expertise she held an appointment as  an Assistant Professor at the Medical School of  Democritus University of Thrace, as well as a visiting Assistant Professor at the School of Medicine and the Department of Obstetrics and Gynecology of the University of British Columbia (UBC) in Canada.

She has clinical experience in the field since 1998, starting as a graduate student during her Masters Degree in “Prenatal Genetics and Fetal Medicine” at University College London. She completed her doctoral thesis Ph.D in Human Genetics and then remained as a Research Fellow in the Obstetrics and Gynecology Department of University College London (UCL) specializing in Preimplantation Genetic Diagnosis (PGD) for chromosomal abnormalities part of the Human Genetics and Embryology Group.

With experience of more than fifteen years as a Geneticist and Clinical Embryologist she has enjoyed fruitful collaborations on a clinical or research level in private clinics, hospitals, and university clinics in England, USA, Canada, Malta and Greece. She is an accredited "Senior Embryologist" by  the European Society of Human Reproduction and Embryology (ESHRE) and was awarded the Intracytoplasmic Sperm Injection (ICSI) license by the Human fertilization and Embryology Authority (HFEA), prior to being employed as an IVF Laboratory Director.

She is passionate about academic education and maintaining a balance between her research activities and clinical commitments. She would like to focus on the investigation of immunology of the preimplantation embryo and implantation, as well as the epigenetics of the technique of vitrification on oocytes and embryos. Her personal mission as a member of the scientific community is the advancement of knowledge on a theoretic and research level, along with continued improvements on medical education.

Research Interests

Epigenetics of vitrification on oocytes, cleavage stage embryos and blastomeres

Toxic effect of various cryoprotectant molecules on embryo development depending on combination patterns, concentrations and times of exposure 

Immunology of implantation and the role of IGF-1 on infertility and endometriosis

Publications
Scientific Activities

Raman BansalPhD

Postdoctoral Researcher
Department of Entomology
The Ohio State University
Address:Wooster
Biography

After receiving his B.S. (Agriculture) and M.S. (Entomology) from Punjab Agricultural University of Ludhiana, India, Raman Bansal moved to Kansas State University (KSU), Manhattan, KS, USA to earn PhD in Entomology. At KSU, Raman’s primary research area was insect microbiology with a specific focus on elucidating the role of bacterial symbionts in plant-insect interactions. He obtained his PhD in 2010 and then went on to work briefly as research scientist at KSU. Towards the end of 2010, Raman joined the Ohio State University (OSU) as a postdoctoral researcher. At OSU, much of Raman’s research is focused on the molecular aspects of soybean-soybean aphid interaction with the specific goal of understanding the genetic basis of biotype adaptation in soybean aphid which allows this insect to overcome plant resistance. Besides identifying genes involved in adaptation, his research efforts are directed toward the functional genomics including RNAi for aphid traits relevant to its field management. Likewise, Raman is working to understand the physiology-driven molecular processes for adaptations in brown marmorated stink bug (BMSB), another economic pest in US. His work has led to the development of extensive molecular resources as well as the identification of novel gene targets for BMSB control. Besides conducting research, Raman has served on numerous teaching and extension assignments in his academic career. He has/had been a member of the Entomological Society of America, American Society for Microbiology, and BMSB Working Group-Northeast IPM.

Research Interests

Molecular Plant-Pest Interactions: Pest effector proteins, Genetics of biotype/strain evolution
Microbial symbionts in Insect Ecology: Investigating insect bacterial communities, Symbiont role in plant-insect interactions and insect ecology
Functional genomics for Field Pest Management: RNAi, Tissue genomics, Polyphagy adaptation

Publications
Scientific Activities

Paul Demian Delgado Olgu�nPhD

Advisory Member
Physiology Department
Fudan University
Address:Canada
Biography

Paul Delgado-Olgu�n received his Ph.D. in Biomedical Sciences at the Universidad NacionalAut�noma de Mexico (National Autonomous University of Mexico) in 2005. Then, Paul was a postdoctoral fellow in the Gladstone Institute of Cardiovascular Disease at the University of California, San Francisco. Paul is a Scientist at the Hospital For Sick Children in Toronto, Canada. His research focuses on uncovering the epigenetic mechanisms controlling cardiovascular development, maintenance and disease.

Research Interests

Uncovering the mechanistic involvement of histone modifiers and chromatin organizers in cardiovascular development, maintenance and disease. Paul is using a variety of approaches ranging from analyzing the cardiac and vascular morphology of mutant mouse models, to determining global gene expression profiles and genome-wide chromatin structure in specific embryonic and adult cell types,and stem cell differentiation models, to uncover the cellular and molecular events controlling cardiovascular differentiation, organogenesis and maintenance.

Publications

Publications:

Research Papers

1. Delgado-Olgu�n P, Tarakhovsky A, Bruneau BG.Epigenetic control of vascular stability by the histone methyltransferase Ezh2. (In preparation)

2. Chi L, Delgado-Olgu�n P (2013).Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase family genes in early mouse embryogenesis.Gene Expr Patterns. 13(8):319-327.

3. MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways.Cheng HS, Sivachandran N, Lau A, Boudreau E, Zhao JL, Baltimore D, Delgado-Olguin P, Cybulsky MI, Fish JE. (2013). EMBO Mol Med. 5(7):949-66.

4. Delgado-Olgu�n P, Huang Y, Li X, Christodolou D, Seidman CE, Seidman JG,Tarakhovsky A, Bruneau BG. (2011). Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.Nature Genetics. 44(3):343-7doi: 10.1038/ng.1068.

5. Zhang SS, Kim K, Rosen A, Smyth JW, Sakuma R, Delgado-Olgu�n P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman G, Kim J, Rose RA, Marsden PA, Zhu Y, Zhou Y,Miquerol L, Henkelman MR, Stainier DYR, Shaw RM, Hui CC, Bruneau BG, Backx PH. (2011) Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. ProcNatlAcadSci U S A. 16:13576-13581.

6. Wyngaarden LA, Delgado-Olgu�n P, Su IH, Logan MP, Tarakhovsky A, Bruneau BG, SevanHopyan. (2011) Epigenetic determination of proximodistal limb bud fate by Ezh2.Development138:3759-3767.

7. Delgado-Olgu�n P, Brand-Arzamendi K, Scott IC, Stainier DY, Recillas-Targa F, Bruneau BG. (2011) CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors.J. Biol. Chem.286:12483-12494.

8. Takeuchi JK, Togi K, Lou X, Alexander J, Delgado-Olgu�n P, Holloway A, Mori A, Munson C, Wylie J, Sukonnik T, Kaynak B, Zhu Y, Yuqing Zhou, Yeh R. Henkelman M, Harvey R, Izumo S, Metzger D, Chambon C, Stainier DY, Pollard K, Scott IC, Bruneau BG.(2011) Chromatin Remodeling Complex Dosage Modulates Transcription Factor Function in Heart Development. Nature Communications.2:187

9. Ieda M, Fu JD, Delgado-Olgu�n P,Vedantham V, Hayashi Y, Bruneau BG, Srivastava D. (2010) Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell. 142:375-86.

10. Hern�ndez-Hern�ndez JM, Delgado-Olgu�n P, Aguill�n-Huerta V, Furlan-Magaril M, Recillas-Targa F, Coral-V�zquez RM. (2009) Sox9 represses alpha-sarcoglycan gene expression in early myogenic differentiation. J. Mol. Biol.394:1-14.

11. Delgado-Olgu�n P, Hern�ndez-Hern�ndez JM, Salamanca F, Recillas-Targa F, Coral-V�zquez RM. (2008). Identification of two E-boxes that negatively modulate the activity of MyoD on the alpha-sarcoglycan core promoter.Biochim.Biophys.Acta. 1779:74-80.

12. Delgado-Olgu�n P, Rosas-Vargas H, Recillas-Targa F, Salamanca F, and Coral-V�zquez R.(2006).Partial characterization of the ?-sarcoglycan promoter and its responsiveness to MyoD.BiochimBiophysActa. 1759:240�246.

13. Delgado-Olgu�n P, Rosas-Vargas H, Recillas-Targa F, Zentella A, Bermumez de Leon M, Cisneros B, Salamanca F, and Coral-V�zquez R. (2004). NFI-C2 negatively regulates ?-sarcoglycan promoter activity in C2C12 myoblasts. Biochem. Biophys. Res. Commun. 319: 1032-1039.

14. Pe�aloza R, Delgado P, Arenas D, Barrientos C, Buentello L, Loeza F and Salamanca F. (2001). (AC)n dinucleotide repeat polymorphism in 5� beta-globin gene in native and Mestizo Mexican populations. Hum. Biol. 73:885�890.

Review Papers:

1. Delgado-Olgu�n P, Recillas-Targa F. Chromatin structure of pluripotent stem cells and induced pluripotent stem cells. (2011).Brief.Funct. Genomics.10:37-39. (Invited review).

2. Guerrero G, Delgado-Olgu�nP, Escamilla-Del-Arenal M, Furlan-Magaril M, Rebollar E, De La Rosa-Velazquez IA, Soto-Reyes E, Rincon-Arano H, Valdes-Quezada C, Valadez-Graham V, Recillas-Targa F. (2007). Globin genes transcriptional switching, chromatin structure and linked lessons to epigenetics in cancer: A comparative overview. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 147:750�760.

3. Delgado-Olgu�n P, Takeuchi JK, Bruneau BG. (2006). Chromatin modification and remodeling in heart development. Sci. World J. 6:1851�1861.

Abstracts:

1. Delgado-Olgu�n P, Tarakhovsky A, Bruneau BG. (2010) Epigenetic Control of Cardiac Growth by the Histone Methyltransferase Ezh2. Circ. Res. 107:e37.

Scientific Activities

Awards and Honors:

2012 � present: Research program funded by Operational Funding from the Hospital for Sick Children (SicKKids)

2006 - 2008: Postdoctoral Scholar

California Institute for Regenerative Medicine

2000 - 2004: Ph.D. studies granted by the ConsejoNacional de Ciencia y Tecnolog�a(CONACyT) - (National Council of Science and Technology) and the Direcci�nGeneral de Posgrado, Universidad NacionalAut�noma de M�xico (National Autonomous University of Mexico)

2000: Degree in Biology with Honors

Facultad de Estudios Profesionales Iztacala(Professional Studies Faculty Iztacala),Universidad NacionalAut�noma de M�xico(National Autonomous University of Mexico)

1996 - 1999: Biology career course in the �Programa de Alta ExigenciaAcad�mica� (High Academic Demanding Program), Facultad de Estudios Profesionales Iztacala (Professional Studies Faculty), Universidad NacionalAut�noma de M�xico(National Autonomous University of Mexico)

Invited Presentations:

September 28, 2010: University of Illinois at Chicago, Department of Biological Sciences. Molecular, Cellular and Developmental Biology Seminars, Chicago, Illinois, USA.

Epigenetic Control of Cardiac Development and Growth by the Histone Methyltransferase Ezh2.

April 13, 2011: Max Plank Institute for Heart and Lung Research, Bad Nauheim, Germany.

Epigenetic Gene Repression in Cardiac Progenitors by Ezh2 Is Essential For Postnatal Cardiac Homeostasis.

June 22, 2011: The Hospital for Sick Children, Toronto, ON, Canada.

Epigenetic regulation of cardiac homeostasis and cardiovascular development.

September 20, 2011: Victor Chang Cardiac Research Institute, Sydney, Australia.

Epigenetic regulation of cardiac homeostasis and cardiovascular development.

October 10, 2012: Department of Molecular Genetics, University of Toronto. Epigenetic Control of Cardiovascular Development and Maintenance -Faculty Appointment Seminar.


Thomas LufkinPhD

Professor
Department of Biology
Clarkson University, NY
Address:USA
Biography

Thomas Lufkin, Ph.D. is Professor and Bayard & Virginia Clarkson Endowed Chair in Biology, Department of Biology, Clarkson University, USA where he directs the program in Stem Cell and Regenerative Medicine. Previously he was Senior Group Leader in Stem Cell & Developmental Biology, Genome Institute of Singapore; Professor, Department of Biological Science, National University of Singapore. Prior to that he was a Professor of Developmental and Molecular Biology at the Mt Sinai School of Medicine in New York City. He completed postdoctoral training at the LGME, Strasbourg, France, in Molecular Embryology with US National Academy of Sciences member Pierre Chambon. He received his Ph.D. from Cornell University in Molecular Biology and Virology and his A.B. from the University of California, Berkeley in Cell Biology where he worked with Nobel Laureate Donald Glaser. He holds 5 USA patents on stem cells and genetic engineering and has received numerous research grants from the National Science Foundation, March of Dimes and NIH. He received the March of Dimes Basil O�Conner Faculty Award, Lucille B. Markey Scholarship in Molecular Biology, Alfred P. Sloan Research Fellowship in Neuroscience, American Cancer Society Postdoctoral Fellowship and a Morton J. Levy Predoctoral Fellowship. He serves as Editor-in-Chief of the Cell and Developmental Biology Journal and OA Biology and is on the Senior Editorial Board of the American Journal of Stem Cells and is an editorial board member of 11 other reputed international peer reviewed journals and has served on numerous national and international scientific review panels. He has over 110 peer-reviewed publications, numerous books and chapters and routinely speaks at international scientific meetings.

Research Interests

Our research is in the novel area of Regenerative Medicine and Stem Cell Biology with a focus on the molecular mechanisms controlling vertebral column development and an emphasis on early embryogenesis and embryonic stem cell commitment to specific differentiation pathways, but from a novel Systems Biology point of view. We are commited to understanding how the vertebral column degenerates with aging, and how this process can be reversed using stem cell based approaches. We are investigating the role of transcriptional regulators in the restriction of pluripotent embryonic stem cells into specific lineages that in turn comprise functional pre and postnatal vertebral elements with the goal of applying this knowledge to regenerative medicine using patient- specific induced pluripotent stem (iPS) cells and adult mesenchymal stem cells.

Vertebrate Development, Embryonic Stem Cell Differentiation, Embryogenesis, Developmental Genomics, Gene regulatory networks, Systems Biology, Regenerative Medicine.

Publications

Publications

1. Sng, J. and T. Lufkin, Advances in Stem Cell Therapies, in Pluripotent Stem Cells / Book 1, N. Lenka, Editor 2013, InTech: Rijeka. p. 1-22. DOI: ISBN 980-953-307-708-1

2. Sivakamasundari, V. and T. Lufkin, Stemming The Degeneration: IVD Stem Cells And Stem

Cell Regenerative Therapy For Degenerative Disc Disease. Advances in Stem Cells, 2013. Article ID 724547: p. 1-22. DOI: 10.5171/2013.724547

3. Sivakamasundari, V., P. Kraus, S. Jie, and T. Lufkin, Pax1(EGFP) : New wildtype and mutant

EGFP mouse lines for molecular and fate mapping studies. Genesis, 2013. 51(6): p. 420-9. DOI: 10.1002/dvg.22379

4. Ng, J.H., V. Kumar, M. Muratani, P. Kraus, J.C. Yeo, L.P. Yaw, K. Xue, T. Lufkin, S. Prabhakar, and H.H. Ng, In Vivo epigenomic profiling of germ cells reveals germ cell molecular signatures. Developmental Cell, 2013. 24(3): p. 324-33. DOI: 10.1016/j.devcel.2012.12.011

5. Kumar, V., M. Muratani, N.A. Rayan, P. Kraus, T. Lufkin, H.H. Ng, and S. Prabhakar, Uniform, optimal signal processing of mapped deep-sequencing data. Nature Biotechnology, 2013. DOI: 10.1038/nbt.2596

6. Kraus, P., V. Sivakamasundari, S.L. Lim, X. Xing, L. Lipovich, and T. Lufkin, Making sense of Dlx1 antisense RNA. Developmental Biology, 2013. 376: p. 224�235. DOI: 10.1016/j.ydbio.2013.01.035

7. Chatterjee, S., P. Kraus, V. Sivakamasundari, X. Xing, S.P. Yap, S. Jie, and T. Lufkin, A conditional mouse line for lineage tracing of Sox9 loss-of-function cells using enhanced green fluorescent protein. Biotechnology Letters, 2013. 35(10): p. 1-6. DOI: 10.1007/s10529-013-1303-6

8. Sng, J. and T. Lufkin, Filling the Silent Void: Genetic Therapies for Hearing Impairment. Genetics Research International, 2012. 2012 Article ID 748698: p. 1-9 Epub 2012 Dec 4. DOI: 10.1155/2012/748698

9. Sng, J. and T. Lufkin, Emerging stem cell therapies: treatment, safety, and biology. Stem Cells International, 2012. 2012: p. 521343. DOI: 10.1155/2012/521343

10. Sivakamasundari, V. and T. Lufkin, Bridging the Gap: Understanding Embryonic Intervertebral Disc Development. Cell & Developmental Biology, 2012. 1(2). DOI: 10.4172/cdb.1000103

11. Sivakamasundari, V., H.Y. Chan, S.P. Yap, X. Xing, P. Kraus, and T. Lufkin, New Bapx1(Cre- EGFP) mouse lines for lineage tracing and conditional knockout studies. Genesis: J of Genetics and Development, 2012. 50(4): p. 375-83. DOI: 10.1002/dvg.20802

12. Lee, W.J., P. Kraus, and T. Lufkin, Endogenous tagging of the murine transcription factor Sox5 with hemaglutinin for functional studies. Transgenic Research, 2012. 21(2): p. 293-301. DOI: 10.1007/s11248-011-9531-9

13. Lee, M.Y. and T. Lufkin, Development of the �Three-step MACS�: a novel strategy for isolating rare cell populations in the absence of known cell surface markers from complex animal tissue. J Biomolecular Techniques, 2012: p. Early Access. DOI: 10.7171/jbt.12-2302-003 10

14. Kraus, P., X. Xing, S.L. Lim, M.E. Fun, V. Sivakamasundari, S.P. Yap, H. Lee, R.K. Karuturi, and T. Lufkin, Mouse strain specific gene expression differences for Illumina microarray expression profiling in embryos. BMC Research Notes 2012. 5: p. 232. DOI: 10.1186/1756-0500- 5-232

15. Chatterjee, S., V. Sivakamasundari, W.J. Lee, H.Y. Chan, and T. Lufkin, Making no bones about it: Transcription factors in vertebrate skeletogenesis and disease. Trends in Developmental Biology, 2012. 6: p. 45-52. DOI: 00000

16. Chatterjee, S. and T. Lufkin, Regulatory Genomics: Insights from the Zebrafish. Current Topics in Genetics, 2012. 5: p. 1-10. DOI:

17. Yap, S.P., X. Xing, P. Kraus, V. Sivakamasundari, H.Y. Chan, and T. Lufkin, Generation of mice with a novel conditional null allele of the Sox9 gene. Biotechnology Letters, 2011. 33(8): p. 1551-8. DOI: 10.1007/s10529-011-0608-6

18. Wang, B., T. Lufkin, and J.L. Rubenstein, Dlx6 regulates molecular properties of the striatum and central nucleus of the amygdala. The Journal of Comparative Neurology, 2011. 519(12): p. 2320-34. DOI: 10.1002/cne.22618

19. Phua, S.L., V. Sivakamasundari, Y. Shao, X. Cai, L.F. Zhang, T. Lufkin, and M. Featherstone, Nuclear Accumulation of an Uncapped RNA Produced by Drosha Cleavage of a Transcript Encoding miR-10b and HOXD4. PLoS ONE, 2011. 6(10): p. e25689. DOI: 10.1371/journal.pone.0025689

20. Ng, P. and T. Lufkin, Ch. 16 - Building a Pluripotency Interaction Network for Embryonic Stem Cells, in Embryonic Stem Cells - Basic Biology to Bioengineering, M.S. Kallos, Editor 2011, InTech: Rijeka. p. 305-320. DOI: 10.5772/23634. ISBN 978-953-307-278-4

21. Ng, P. and T. Lufkin, Embryonic Stem Cells: Protein-Interaction Networks. BioMolecular Concepts, 2011. 2(1-2): p. 13-25. DOI: 10.1515/bmc.2011.008

22. Lam, S.H., S.G. Lee, C.Y. Lin, J.S. Thomsen, P.Y. Fu, K.R. Murthy, H. Li, K.R. Govindarajan, L. Nick, G. Bourque, Z. Gong, T. Lufkin, E.T. Liu, and S. Mathavan, Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines. BMC Medical Genomics, 2011. 4(1): p. 41. DOI: 10.1186/1755-8794-4-41

23. Cheong, C.Y. and T. Lufkin, Alternative splicing in self-renewal of embryonic stem cells. Stem Cells International, 2011. In Special Issue on "Stem Cells and Nuclear Reprogramming": p. 560261. DOI: 10.4061/2011/560261

24. Cheong, C.Y., P.M. Lon Ng, R. Ponnampalam, H.H. Tsai, G. Bourque, and T. Lufkin, In silico tandem affinity purification refines an Oct4 interaction list. Stem Cell Research & Therapy, 2011. 2(3): p. 26. DOI: 10.1186/scrt67

25. Chatterjee, S. and T. Lufkin, The Sounds of Silence: Mouse Models of Hearing Loss. Genetics Research International, 2011. DOI: 10.4061/2011/416450

26. Chatterjee, S. and T. Lufkin, Fishing for function: zebrafish BAC transgenics for functional genomics. Molecular BioSystems, 2011. 7(8): p. 2345-51. DOI: 10.1039/c1mb05116d11

27. Chatterjee, S., G. Bourque, and T. Lufkin, Conserved and non-conserved enhancers direct tissue specific transcription in ancient germ layer specific developmental control genes. BMC Developmental Biology, 2011. 11: p. 63. DOI: 10.1186/1471-213X-11-63

28. Chan, H.Y., V. Sivakamasundari, X. Xing, P. Kraus, S.P. Yap, P. Ng, S.L. Lim, and T. Lufkin, Comparison of IRES and F2A-Based Locus-Specific Multicistronic Expression in Stable Mouse Lines. PLoS ONE, 2011. 6(12): p. e28885. DOI: 10.1371/journal.pone.0028885

29. Wang, Y., C.A. Dye, V. Sohal, J.E. Long, R.C. Estrada, T. Roztocil, T. Lufkin, K. Deisseroth, S.C. Baraban, and J.L. Rubenstein, Dlx5 and Dlx6 regulate the development of parvalbuminexpressing cortical interneurons. J Neuroscience, 2010. 30(15): p. 5334-45. DOI:

30. Sheng, D., D. Qu, K.H. Kwok, S.S. Ng, A.Y. Lim, S.S. Aw, C.W. Lee, W.K. Sung, E.K. Tan, T. Lufkin, S. Jesuthasan, M. Sinnakaruppan, and J. Liu, Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect. PLoS Genetics, 2010.6(4): p. e1000914. DOI: 10.1371/journal.pgen.1000914

31. Kraus, P., G. Leong, V. Tan, X. Xing, J.W. Goh, S.P. Yap, and T. Lufkin, A more cost effective and rapid high percentage germ-line transmitting chimeric mouse generation procedure via microinjection of 2-cell, 4-cell, and 8-cell embryos with ES and iPS cells. Genesis: J of Genetics and Development, 2010. 48(6): p. 394-9. DOI: 10.1002/dvg.20627

32. Heng, J.C., B. Feng, J. Han, J. Jiang, P. Kraus, J.H. Ng, Y.L. Orlov, M. Huss, L. Yang, T. Lufkin, B. Lim, and H.H. Ng, The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell, 2010. 6(2): p. 167-74. DOI: 10.1016/j.stem.2009.12.009

33. Han, J., P. Yuan, H. Yang, J. Zhang, B.S. Soh, P. Li, S.L. Lim, S. Cao, J. Tay, Y.L. Orlov, T. Lufkin, H.H. Ng, W.L. Tam, and B. Lim, Tbx3 improves the germ-line competency of induced pluripotent stem cells. Nature, 2010. 463(7284): p. 1096-100. DOI: 10.1038/nature08735

34. Chia, N.Y., Y.S. Chan, B. Feng, X. Lu, Y.L. Orlov, D. Moreau, P. Kumar, L. Yang, J. Jiang, M.S. Lau, M. Huss, B.S. Soh, P. Kraus, P. Li, T. Lufkin, B. Lim, N.D. Clarke, F. Bard, and H.H. Ng, Agenome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature, 2010. 468(7321): p. 316-20. DOI: 10.1038/nature09531

35. Cheong, C.Y. and T. Lufkin, Transcriptional repression in ES cells. J Cell Biochem, 2010. 110(2): p. 288-93. DOI: 10.1002/jcb.22576

36. Chatterjee, S., L. Min, R.K. Karuturi, and T. Lufkin, The role of post-transcriptional RNA processing and plasmid vector sequences on transient transgene expression in zebrafish. Transgenic Research, 2010. 19(2): p. 299-304. DOI: 10.1007/s11248-009-9312-x

37. Chatterjee, S., P. Kraus, and T. Lufkin, A symphony of inner ear developmental control genes. BMC Genetics, 2010. 11: p. 68. DOI: 10.1186/1471-2156-11-68

38. Feng, B., J. Jiang, P. Kraus, J.H. Ng, J.C. Heng, Y.S. Chan, L.P. Yaw, W. Zhang, Y.H. Loh, J. Han, V.B. Vega, V. Cacheux-Rataboul, B. Lim, T. Lufkin, and H.H. Ng, Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nature Cell Biology, 2009. 11(2): p. 197-203. DOI: 10.1038/ncb182712

39. Tay, Y.M., W.L. Tam, Y.S. Ang, P.M. Gaughwin, H. Yang, W. Wang, R. Liu, J. George, H.H. Ng, R.J. Perera, T. Lufkin, I. Rigoutsos, A.M. Thomson, and B. Lim, MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1. Stem Cells, 2008. 26(1): p. 17-29. DOI: 10.1634/stemcells.2007-0295

40. Jeong, J., X. Li, R.J. McEvilly, M.G. Rosenfeld, T. Lufkin, and J.L. Rubenstein, Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs. Development, 2008. 135(17): p. 2905-16. DOI: 10.1242/dev.019778

41. Wang, Z.X., C.H. Teh, J.L. Kueh, T. Lufkin, P. Robson, and L.W. Stanton, Oct4 and Sox2 directly regulate expression of another pluripotency transcription factor, Zfp206, in embryonic stem cells. J Biol Chem, 2007. 282(17): p. 12822-30. DOI: 10.1074/jbc.M611814200

42. Wang, Z.X., J.L. Kueh, C.H. Teh, M. Rossbach, L. Lim, P. Li, K.Y. Wong, T. Lufkin, P. Robson, and L.W. Stanton, Zfp206 Is a Transcription Factor That Controls Pluripotency of Embryonic Stem Cells. Stem Cells, 2007. 25(9): p. 2173-2182. DOI: 10.1634/stemcells.2007-0085

43. Simon, R., T. Lufkin, and A.D. Bergemann, Homeobox gene Sax2 deficiency causes an imbalance in energy homeostasis. Developmental Dynamics, 2007. 236(10): p. 2792-2799. DOI: 10.1002/dvdy.21320

44. Lufkin, T., In Situ Hybridization of Whole-Mount Mouse Embryos with RNA Probes: Hybridization, Washes, and Histochemistry. Cold Spring Harb. Protoc., 2007. DOI: 10.1101/pdb.prot4823

45. Lufkin, T., In Situ Hybridization of Whole-Mount Mouse Embryos with RNA Probes: Preparation of Embryos and Probes. Cold Spring Harb. Protoc., 2007. DOI:10.1101/pdb.prot4822

46. Zhang, J., W.L. Tam, G.Q. Tong, Q. Wu, H.Y. Chan, B.S. Soh, Y. Lou, J. Yang, Y. Ma, L. Chai, H.H. Ng, T. Lufkin, P. Robson, and B. Lim, Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nature Cell Biology, 2006. 8(10): p. 1114-23. DOI: 10.1038/ncb1481

47. Tribioli, C. and T. Lufkin, Long-term room temperature storage of high-quality embryonic stem cell genomic DNA extracted with a simple and rapid procedure. J Biomolecular Techniques, 2006. 17(4): p. 249-51. DOI: 00000

48. Tribioli, C. and T. Lufkin, Bapx1 homeobox gene gain-of-function mice show preaxial polydactyly and activated Shh signaling in the developing limb. Developmental Dynamics, 2006. 235: p. 2483-2492. DOI: 10.1002/dvdy.20867

49. Robledo, R.F. and T. Lufkin, Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus. Genesis: J of Genetics and Development, 2006. 44(9): p. 425-437. DOI: 10.1002/dvg.20233

50. Kraus, P. and T. Lufkin, Dlx homeobox gene control of mammalian limb and craniofacial development. American J Medical Genetics, 2006. 140(13): p. 1366-74. DOI: 10.1002/ajmg.a.3125213

51. Wang, W. and T. Lufkin, Hmx homeobox gene function in inner ear and nervous system cell-type specification and development. Experimental Cell Research, 2005. 306(2): p. 373-9. DOI:10.1016/j.yexcr.2005.03.016

52. Price, C., B.C. Herman, T. Lufkin, H.M. Goldman, and K.J. Jepsen, Genetic variation in bone growth patterns defines adult mouse bone fragility. J Bone Miner Res, 2005. 20(11): p. 1983-91. DOI: 10.1359/JBMR.050707

53. Mathavan, S., S.G. Lee, A. Mak, L.D. Miller, K.R. Murthy, K.R. Govindarajan, Y. Tong, Y.L. Wu, S.H. Lam, H. Yang, Y. Ruan, V. Korzh, Z. Gong, E.T. Liu, and T. Lufkin, Transcriptome analysis of zebrafish embryogenesis using microarrays. PLoS Genetics, 2005. 1(2): p. 260-76. DOI: 10.1371/journal.pgen.0010029

54. Lufkin, T., Hox Genes: Embryonic Development, in Encyclopedia of Life Sciences2005, John Wiley & Sons, Ltd: New York. DOI: 10.1038/npg.els.0005046. ISBN 9780470015902

55. Lufkin, T., The easy part is making the knockout. Developmental Dynamics, 2005. 233(3): p. 1173-1174. DOI: 10.1002/dvdy.20387

56. Basson, M.A., S. Akbulut, J. Watson-Johnson, R. Simon, T.J. Carroll, R. Shakya, I. Gross, G.R. Martin, T. Lufkin, A.P. McMahon, P.D. Wilson, F.D. Costantini, I.J. Mason, and J.D. Licht, Sprouty1 Is a Critical Regulator of GDNF/RET-Mediated Kidney Induction. Developmental Cell, 2005. 8(2): p. 229-239. DOI: 10.1016/j.devcel.2004.12.004

57. Wang, W., J.F. Grimmer, T.R. Van De Water, and T. Lufkin, Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx. Developmental Cell, 2004. 7(3): p. 439-53. DOI: 10.1016/j.devcel.2004.06.016

58. Zhao, F., T. Lufkin, and B.D. Gelb, Expression of Tfap2d, the gene encoding the transcription factor Ap-2delta, during mouse embryogenesis. Gene Expression Patterns, 2003. 3(2): p. 213-7. DOI: 10.1016/S1567-133X(02)00067-4

59. Simon, R. and T. Lufkin, Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation. Molecular and Cellular Biology, 2003. 23(24): p. 9046-60. DOI: 10.1128/MCB.23.24.9046- 9060.2003

60. Lufkin, T., ed. Murine homeobox gene control of embryonic patterning and organogenesis. Advances in Developmental Biology And Biochemistry. Vol. 13. 2003, Elsevier: London. 276. DOI: 978-0444514981

61. Lufkin, T., Hox genes and embryonic development, in Nature Encyclopedia of the Human Genome, D.N. Cooper, Editor 2003, Nature Publishing Group: London. p. Chapter 46. DOI:10.1038/npg.els.0005046. ISBN

62. Tribioli, C., R.F. Robledo, and T. Lufkin, The murine fork head gene Foxn2 is expressed in craniofacial, limb, CNS and somitic tissues during embryogenesis. Mechanisms of Development, 2002. 118(1-2): p. 161-3. DOI: 10.1016/S0925-4773(02)00220-414

63. Robledo, R.F., L. Rajan, X. Li, and T. Lufkin, The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development. Genes & Development, 2002. 16(9): p. 1089-101. DOI: 10.1101/gad.988402

64. Depew, M.J., T. Lufkin, and J.L. Rubenstein, Specification of jaw subdivisions by Dlx genes. Science, 2002. 298(5592): p. 381-5. DOI: 10.1126/science.1075703

65. Wang, W., E.K. Chan, S. Baron, T. Van De Water, and T. Lufkin, Hmx2 homeobox gene control of murine vestibular morphogenesis. Development, 2001. 128(24): p. 5017-5029. DOI: 00000

66. Wang, W. and T. Lufkin, The murine Otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus. Developmental Biology, 2000. 227(2): p. 432-49. DOI: 10.1006/dbio.2000.9902

67. Wang, W., P. Lo, M. Frasch, and T. Lufkin, Hmx: an evolutionary conserved homeobox gene family expressed in the developing nervous system in mice and Drosophila. Mechanisms of Development, 2000. 99(1-2): p. 123-37. DOI: 10.1016/S0925-4773(00)00488-3

68. Taylor Clelland, C.L., L. Craciun, C. Bancroft, and T. Lufkin, Mapping and developmental expression analysis of the WD-repeat gene Preb. Genomics, 2000. 63(3): p. 391-9. DOI:10.1006/geno.1999.6089

69. Lufkin, T., Developmental Control by Hox Transcriptional Regulators and their Cofactors, in Transcription Factors, J. Locker, Editor 2000, Bios Scientific Publishers: Oxford. p. 215-235. DOI: 00000. ISBN 978-0124543454

70. Li, X. and T. Lufkin, Cre recombinase expression in the floorplate, notochord and gut epithelium in transgenic embryos driven by the Hoxa-1 enhancer III. Genesis: J of Genetics and Development, 2000. 26(2): p. 121-2. DOI: 10.1002/(SICI)1526-968X(200002)26:2 121

71. Tribioli, C. and T. Lufkin, The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen. Development, 1999. 126(24): p. 5699-711.

72. Kraus, P. and T. Lufkin, Mammalian Dlx homeobox gene control of craniofacial and inner ear morphogenesis. J Cell Biochem, 1999. 32-33: p. 133-40. DOI: 10.1002/(SICI)1097-4644(1999)75:32.

73. Wang, W., T. Van De Water, and T. Lufkin, Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Development, 1998. 125(4): p. 621-34. DOI: 00000

74. Swanson, L., T. Lufkin, and D. Colman, Chapter 2: Functional Architecture of Nervous Systems, Section II. Cellular and Molecular Neuroscience, in Fundamental Neuroscience., F.E. Bloom, Editor 1998, Academic Press: San Diego. p. 7-35. DOI: 00000. ISBN 978-0123740199

75. Wang, W., K. Yoshiura, J. Murray, and T. Lufkin, Assignment of the murine Hmx1 homeobox gene to the proximal region of mouse chromosome 5. Mammalian Genome, 1997. 8(11): p. 869-70. DOI: 10.1007/s003359900598

76. Wang, W. and T. Lufkin, Assignment of the murine Hmx2 and Hmx3 homeobox genes to the distal region of mouse chromosome 7. Chromosome Research, 1997. 5(7): p. 501-2. DOI:0000015

77. Wang, W. and T. Lufkin, Otp maps to mouse Chromosome 13. Mammalian Genome, 1997. 8: p.537-538. DOI: 10.1007/s003359900494

78. Tribioli, C. and T. Lufkin, Molecular cloning, chromosomal mapping and developmental expression of BAPX1, a novel human homeobox-containing gene homologous to Drosophila bagpipe. Gene, 1997. 203(2): p. 225-33. DOI: 10.1016/S0378-1119(97)00520-9

79. Tribioli, C., M. Frasch, and T. Lufkin, Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton. Mechanisms of Development, 1997. 65(1-2): p. 145-62. DOI: 10.1016/S0925-4773(97)00067-1

80. Nikolova, M., X. Chen, and T. Lufkin, Nkx2.6 expression is transiently and specifically restricted to the branchial region of pharyngeal-stage mouse embryos. Mechanisms of Development, 1997. 69(1-2): p. 215-8. DOI: 10.1016/S0925-4773(97)00174-3

81. Lufkin, T., Transcriptional regulation of mammalian Hox genes during embryogenesis. Critical Reviews in Eukaryotic Gene Expression, 1997. 7(3): p. 193-213. DOI: 10.1615/CritRevEukarGeneExpr.v7.i3.10

82. Li, X., W. Wang, and T. Lufkin, Dicistronic lacZ and alkaline phosphatase reporter constructs permit simultaneous histological analysis of expression from multiple transgenes. BioTechniques,1997. 23: p. 874-882. DOI: 00000

83. Chen, X. and T. Lufkin, Linkage mapping of Sax2 to mouse Chromosome 5. Mammalian Genome, 1997. 8: p. 679-698. DOI: 10.1007/s003359900541

84. Wang, W., X. Chen, H. Xu, and T. Lufkin, Msx3: a novel murine homologue of the Drosophila msh homeobox gene restricted to the dorsal embryonic central nervous system. Mechanisms of Development, 1996. 58(1-2): p. 203-15. DOI: 10.1016/S0925-4773(96)00562-X

85. Lufkin, T., Transcriptional control of Hox genes in the vertebrate nervous system. Current Opinion in Genetics & Development, 1996. 6(5): p. 575-580. DOI: 10.1016/S0959-437X(96)80086-4

86. Chen, X., X. Li, W. Wang, and T. Lufkin, Dlx5 and Dlx6: an evolutionary conserved pair of murine homeobox genes expressed in the embryonic skeleton. Annals of the New York Academy of Sciences, 1996. 785: p. 38-47. DOI: 10.1111/j.1749-6632.1996.tb56242.x

87. Mark, M., F.M. Rijli, T. Lufkin, P. Dolle, P. Gorry, and P. Chambon, Hox Gene Function and the Development of the Head, in Neural Cell Specification, B.J. Juurlink, et al., Editors. 1995, Springer US. p. 3-16. DOI: 10.1007/978-1-4615-1929-4_1. ISBN 978-1-4613-5790-2

88. Lufkin, T., Chapter 5: Gene targeting in mammalian development and physiology, in Gene Targeting, M. Vega, Editor 1995, CRC Press: New York. p. 123-147. DOI: 00000. ISBN 978 0849389504

89. Lampron, C., C. Rochette-Egly, P. Gorry, P. Dolle, M. Mark, T. Lufkin, M. LeMeur, and P. Chambon, Mice deficient in cellular retinoic acid binding protein II (CRABPII) or in both 16 CRABPI and CRABPII are essentially normal. Development, 1995. 121(2): p. 539-48. DOI:00000

90. Frasch, M., X. Chen, and T. Lufkin, Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila. Development, 1995. 121(4): p. 957-74. DOI: 00000

91. Boylan, J.F., T. Lufkin, C.C. Achkar, R. Taneja, P. Chambon, and L.J. Gudas, Targeted disruption of retinoic acid receptor alpha (RAR alpha) and RAR gamma results in receptorspecific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism. Molecular and Cellular Biology, 1995. 15(2): p. 843-51. DOI: 00000

92. Mendelsohn, C., D. Lohnes, D. Decimo, T. Lufkin, M. Lemeur, P. Chambon, and M. Mark, Function of the retinoic acid receptors (RARs) during development .2. Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development, 1994. 120(10): p. 2749- 2771. DOI: 00000

93. Gorry, P., T. Lufkin, A. Dierich, C. Rochette-Egly, D. Decimo, P. Doll�, M. Mark, B. Durand, and P. Chambon, The cellular retinoic acid binding protein I is dispensable. Proc Natl Acad Sci USA, 1994. 91(19): p. 9032-9036. DOI: 10.1073/pnas.91.19.9032

94. Mark, M., T. Lufkin, J.L. Vonesch, E. Ruberte, J.C. Olivo, P. Dolle, P. Gorry, A. Lumsden, and P. Chambon, Two rhombomeres are altered in Hoxa-1 mutant mice. Development, 1993. 119(2): p. 319-38. DOI: 00000

95. Mark, M., T. Lufkin, P. Dolle, A. Dierich, M. LeMeur, and P. Chambon, Roles of Hox genes: what we have learnt from gain of function and loss of function mutations in the mouse. C R Acad Sci III - Life Sciences, 1993. 316: p. 995-1008. DOI: 00000

96. Lufkin, T., D. Lohnes, M. Mark, A. Dierich, P. Gorry, M.P. Gaub, M. LeMeur, and P. Chambon, High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. Proc Natl Acad Sci USA, 1993. 90(15): p. 7225-9. DOI: 00000

97. Doll�, P., T. Lufkin, R. Krumlauf, M. Mark, D. Duboule, and P. Chambon, Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest loss of rhombomeres 4 and 5 in homozygote Hoxa-1 (Hox-1.6) mutant embryos. Proc Natl Acad Sci USA, 1993. 90: p. 7666- 7670. DOI: 10.1073/pnas.90.16.7666

98. Mark, M., T. Lufkin, A. Dierich, M. LeMeur, and P. Chambon, Inactivation du gene Hox-1.6 chez la souris: vers le decodage des reseaux d'homeogenes de mammiferes. Medecines/Sciences,1992. 8: p. 334-339. DOI: 00000

99. Lufkin, T., M. Mark, C.P. Hart, P. Dolle, M. LeMeur, and P. Chambon, Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene. Nature, 1992. 359(6398): p. 835-41. DOI: 10.1038/359835a0

100. Lohnes, D., A. Dierich, P. Kastner, C. Lampron, M. LeMeur, T. Lufkin, C. Mendelsohn, H. Nakshatri, and P. Chambon, Retinoid receptors and binding proteins. Journal of Cell Science, 1992. 16: p. 69-76. DOI: 0000017

101. Lufkin, T., A. Dierich, M. LeMeur, M. Mark, and P. Chambon, Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression. Cell, 1991. 66(6): p. 1105-19. DOI: 10.1016/0092-8674(91)90034-V

102. Lufkin, T., A.E. Jackson, W.T. Pan, and C. Bancroft, Proximal rat prolactin promoter sequences direct optimal, pituitary cell-specific transcription. Molecular Endocrinology, 1989. 3(3): p. 559-66. DOI: 10.1210/mend-3-3-559

103. Lufkin, T. and C. Bancroft, Identification by cell fusion of gene sequences that interact with positive trans-acting factors. Science, 1987. 237(4812): p. 283-6. DOI:10.1126/science.3474782

104. Lavery, D., S.M. Fu, T. Lufkin, and S. Chen-Kiang, Productive infection of cultured human lymphoid cells by adenovirus. J Virology, 1987. 61: p. 1466-1472. DOI: 000000

105. White, B.A., T. Lufkin, G.M. Preston, and C. Bancroft, RNA dot and blot hybridization: selected procedures for endocrine and neuroendocrine studies. Methods in Enzymology, 1986. 124: p. 269-78. DOI: 10.1016/0076-6879(86)24020-3

106. White, B.A., G.M. Preston, T.C. Lufkin, and C. Bancroft, Detection of two chromatin proteins which bind specifically to the 5'-flanking region of the rat prolactin gene. Molecular and Cellular Biology, 1985. 5(11): p. 2967-74. DOI: 10.1128/MCB.5.11.2967

Scientific Activities

RECENT CONFERENCES & INVITED ENGAGEMENTS AS SPEAKER

� 6 September 2012 Stem Cell Society Singapore (SCSS) "Stem Cell Based Therapy" Singapore, Singapore

� 27 August 2012 Dept of Pharmacology, NUS School of Medicine �Stem Cells and Regenerative Medicine� Singapore, Singapore

� 21 August 2012 Clarkson University �Builiding a Skeletogenic GRN� Potsdam, NY USA

� 26 June 2012 Biomedical Grant Enhancement Workshop �Animals Studies � Problems and Pitfalls�

� Nanyang Technological University, Singapore, Singapore

� 12 June 2012 Van Andel Research Institute �Gene Regulatory Networks Controlling Skeletogenesis� Grand Rapids, MI USA

� 21 May 2012 Nanyang Technological University �Gene Regulatory Networks Controlling Skeletogenesis� Singapore, Singapore

� 22 Mar 2012 Cold Spring Harbor Systems Biology: Global Regulation of Gene Expression "An

Integrative Approach To Identify The In Vivo Gene Regulatory Network During Chondrogenesis" Cold Spring Harbor Laboratory, NY USA

� 20 Mar 2012 Maine Medical Research Center �Gene Regulatory Networks Controlling Skeletogenesis� Portland, ME USA

� 17 Sep 2011 Australasian Microarray and Associated Technologies Association (AMATA) Conference " Gene Regulatory Networks in Embryogenesis" AMATA Program Committee, Hobart Australia

� 11 Aug 2010 Cold Spring Harbor/Wellcome Trust Conference on Interactome Networks and Systems Biology "Developmental Genomics and Gene Regulatory Networks" Sanger Center, Hinxton England

� 01 Dec 2009 Co-Chair - Annual World Congress of Gene-2009 "Gene Regulatory Networks and Loss of Pluripotency" Annual World Congress of Gene, Foshan China

� 27 Sep 2008 HUGO 2008 "Stem Cells & Developmental Genomics" Human Genome Organization, Hyderabad India

� 05 Oct 2007 HUPO 2007 "Stem Cells & Developmental Biology Proteomics" Human Proteome Organization, Seoul, Korea, South Korea

� 02 Sep 2006 Cold Spring Harbor/Wellcome Trust Conference on Interactome Networks and Systems Biology "Developmental Gene Regulatory Networks" Sanger Center, Hinxton England

HONORS AND AWARDS

1996-99 March of Dimes Basil O�Conner Jr. Faculty Award

1994-98 Lucille B. Markey Scholar in Molecular Biology

1994-97 Alfred P. Sloan Research Fellowship in Neuroscience

1993-95 Deafness Foundation, Transgenic Models of Inner Ear Development

1990-93 Bourse de Directeur d�Equipe, CNRS, France

1987-90 American Cancer Society Postdoctoral Fellowship

1983-87 Morton J. Levy Predoctoral Fellowship

PUBLICATION CITATION INDICIES

� Total Citations = 6423

� h-index = 35

� i10-index = 53

� http://scholar.google.com.sg/citations?user=-hSF9dIAAAAJ&hl=en


Morishita RyuichiPhD

Professor
Department of Clinical Gene Therapy
Osaka University Medical School
Address:Japan
Biography

Ryuichi Morishita, M.D., Ph.D., graduated Osaka University Medical School in 1987, and received Ph. D. from Osaka University in 1991. After following postdoctoral Fellow at Stanford University School of Medicine, he served as an Assistant Professor, Department of Geriatric Medicine, Osaka University Medical School from 1994 to 1998. Then, from 1998 to 2003, he was Associate Professor, Division of Gene Therapy Science, Osaka University Medical School. Then, he became Professor & Chairman of Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University Medical School from 2003. He is also a member of Industry-Academia Relationship, Ministry of Education, Science and Culture of Japan. From 2013, he is selected as a Member of Council for Regulatory Reform, Cabinet Office (Abe Cabinet).

Professor Morishita received over 20 awards from various academic societies including Harry Goldbratt Award in Council of High Blood Pressure, American Heart Association, Award in Japanese of Japan Medical Society, Sato Award in 27th annual meeting of the Japanese Circulation Society and Invitrogen-Nature-Biotechnology Award.

Professor Morishita is currently on the editorial board of over 30 scientific journals including The Open Gene Therapy Journal (Editor-in-Chief), Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry (Editor-in-Chief), Gene Therapy, ATVB, Circulation and Hypertension. He is currently an Executive Editor of Hypertension Research. He has published over 400 original articles and review papers, primarily on gene therapy and molecular biology in cardiovascular disease. In addition, Professor Morishita is a Board Member of numerous medical organizations, including Japanese Society of Hypertension, Japanese Society of Gene Therapy, Japan Society of Vascular Medicine, Japanese Society of Anti-aging and others.

He also worked as a member of Intellectual Property Committee of Koizumi & Abe Cabinet. His professional activities & appointments include Committee for Industry-Academia Relationship, Ministry of Education, Science and Culture of Japan, Vice Chairman, Bio-Venture Association Originated from Universities, and others.

Research Interests

Gene therapy, Immunology, Metabolic disorders

Publications

Publications

1. Higaki J, Ogihara T, Nakamaru M, Morishita R, Kumahara Y. Effects of carvedilol on plasma hormonal and biochemical factors and renal function in Japanese patients with essential hypertension. Drugs 1988,36:64-68.

2. Higaki J; Okuno M; Nakamaru M; Morishita R; Himeno S; Ogihara T. Changes in plasma active renin and prorenin after endoscopic retrograde pancreatography. Methods and Findings in Experimental and Clinical Pharmacology 1989;11:703-705.

3. Morishita R; Higaki J; Ogihara T. Endothelin stimulates aldosterone biosynthesis by dispersed rabbit adreno-capsular cells. Biochemical and Biophysical Research Communications 1989;160:628-632.

4. Higaki J; Morishita R; Ogihara T. Measurements of enzyme activity and immunoreactivity of plasma renin. Limitations of the conventional method for assay of plasma renin catalytic activity. Journal of Clinical Chemistry and Clinical Biochemistry, 1989;27:201-204.

5. Higaki J; Morishita R; Ogihara T; Nishiura M. Effects of aging on human plasma renin: simultaneous multiple assays of enzyme activity and immunoactivity of plasma renin. Acta Endocrinologica, 1989;120:81-86.

6. Higaki J, Morishita R, Nakamaru M, Mikami H, Ogihara T. Thiazide-induced cerebral infarction in an elderly hypertensive patients with carotid artery stenosis. Advances in Therapy. 1989;6:180-185.

7. Morishita R; Higaki J; Mikami H; Ogihara T. Effect of cyclosporin A on aldosterone production by dispersed rabbit adreno-capsular cells. Life Sciences, 1990, 46:1985-1989.

8. Higaki J, Mikami H, Otsuka A, Iwatsubo H, Katahira K, Moriguchi A, Morishita R, Hata T, Ogihara T. Effect of two years of enalapril treatment on the quality of ligfe of elderly patients with essential hypertension complicated by other diseases. Current Therapeutic Research 1990;47:620-626.

9. Nakamura F; Nagano M; Higaki J; Higashimori K; Katahira K; Morishita R; Mikami H; Ogihara T. Regression of left ventricular hypertrophy by angiotensin converting enzyme inhibitor in reduced renal mass hypertensive rats. Journal of Hypertension. 1991;9:S398-399.

10. Morishita R; Higaki J; Nagano M; Mikami H; Ogihara T; Tanaka T; Ishii K; Okunishi H; Miyazaki M. Consistent activation of prorenin mRNA in renal hypertensive rats. Canadian Journal of Physiology and Pharmacology, 1991;69:1364-1366.

11. Higaki J; Miya A; Miki T; Morishita R; Mikami H; Takai S; Ogihara T. Contribution of the activation of the ras oncogene to the evolution of aldosterone- and renin-secreting tumors. Journal of Hypertension 1991;9:135-137.

12. Morishita R; Higaki J; Okunishi H; Tanaka T; Ishii K; Nagano M; Mikami H; Ogihara T; Murakami K; Miyazaki M. Changes in gene expression of the renin-angiotensin system in two-kidney, one clip hypertensive rats. Journal of Hypertension, 1991;9:187-192.

13. Morishita R, Higaki J, Okunishi H, Kawamoto T, Ishii K, Nakamura F, Katahira K, Nagano M, Mikami H, Miyazaki M, Ogihara T. Effect of long term treatment with an angiotensin converting enzyme inhibitor on the renin angiotensin system in spontaneously hypertensive rats. Clinical and Experimental Pharmacology and Physiology 1991;18:685-690.

14. Morishita R. Higaki J. Nakamura F. Tomita N. Yu H, Nagano M, Mikami H, Ogihara T. Role of vascular angiotensin II in hypertension induced vascular hypertrophy of spontaneously hypertensive rats. Blood Pressure 1992;1:41-47.

15. Morishita R; Higaki J; Katahira K, Nakamura F, Nagano M; Mikami H; Okunishi H, Miyazaki M, Ogihara T. Investigation of the fectors of the renin angiotensin system in renal hypertensive rats. Journal of Physiology 1992;446:370.

16. Katsuya T, Higaki J, Miki T, Nakura J, Ikegami H, Morishita R, Nagano M, Higashimori K, Nakamura F, Mikami H, Ogihara T. Substrain comparison of genetically hypertensive rats using DNA fingerprinting, and genetic analysis of blood pressure in the inbred rats. The Tohoku Journal of Experimental Medicine 1992;165:253-260.

17. Ogihara T, Ishikawa H, Mikami H, Nonaka H, Higaki J, Kagoshima T, Otsuka A, Higashimori K, Morishita R, IshikawaK. Effects of long-term treatment with delapril on quality of life in hypertensive patients. Current Therapeutic Research 1992;51:254-260.

18. Ogihara T, Mikami H, Otsuka A, Nagano M, Matsuo K, Saeki S, Morishita R, Suzuki T, Naka T, Hata T. Effect of nilvadipine on quality of life in patients with essential hypertension. Current Therapeutic Research 1992;51:154-162.

19. Ogihara T, Nakagawa M, Ishikawa H, Mikami H, Takeda K, Nonaka H, Higaki J, Saeki S, Kagoshima T, Matsuo K, Morishita R, Ishikawa K. The effects of temocapril,. a new angiotensin converting enzyme inhibitor, on the quality of life in hypertensive patients. Current Therapeutics Research 1992;52:81-88.

20. Tomita N, Higaki J, Morishita R, Kato K, Mikami H, Kaneda Y, Ogihara T. Direct in vivo gene introduction into rat kidney. Biochemical and Biophysical Research Communications 1992;186:129-34.

21. Morishita R, Higaki J, Nakamura F, Tomita N, Yu H, Nagano M, Mikami H, Ogihara T. Regression of hypertension-induced vascular hypertrophy by an ACE inhibitor and calcium antagonist in the spontaneously hypertensive rat. Blood Pressure 1992;3:41-47.

22. Morishita R; Higaki J; Miyazaki M; Ogihara T. Possible role of the vascular renin-angiotensin system in hypertension and vascular hypertrophy. Hypertension, 1992 19(Suppl):II62-7.

23. Morishita R; Higaki J; Mikami H; Matsukawa N; Ogihara T. Effect of aging on the renin angiotensin system in patients with renovascular hypertension. Methods and Findings in Experimental and Clinical Pharmacology, 1992;14:17-21.

24. Dzau VJ. Morishita R, Gibbons GH. Gene therapy in the cardiovascular diseases. Trends in Biotechnology 1993;11:205-210.

25. Morishita R, Gibbons GH, Kaneda Y, Ogihara T, Dzau VJ. Novel in vitro gene transfer method for study of local modulators in vascular smooth muscle cells. Hypertension 1993;21:894-899.

26. Morishita R; Higaki J; Okunishi H, Nakamura F, Nagano M; Mikami H; Ishii K, Miyazaki M, Ogihara T. Role of tissue renin angiotensin system in two-kidney, one clip hypertensive rats. American Journal of Physiology 1993;264:F510-514.

27. Nakamura F, Nagano M, Higaki J, HIgashimori K, Morishita R, Mikami H, Ogihara T. The angiotensin-converting enzyme inhibitor, perindopril, prevents cardiac hypertrophy in low-renin hypertensive rats. Clinical and Experimental Pharmacology and Physiology 1993;20:135-140.

28. Morishita R. Higaki J. Nagano M. Nakamura F. Tomita N. Zhao Y. Mikami H, Miyazaki M, Ogihara T. Discrepancy between renin mRNA and plasma renin level in angiotensin-converting enzyme inhibitor-treated rats. Clinical and Experimental Pharmacology and Physiology 1993;20:15-20.

29. Morishita R, Gibbons GH, Kaneda Y, Ogihara T, Dzau VJ. Novel and effective gene transfer technique for study of vascular renin angiotensin system. Journal of Clinical Investigation 1993;91:2580-2585

30. Morishita R, Gibbons GH, Ellison KE, Nakajima M, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. Single intraluminal delivery of antisense cdc 2 kinase and PCNA oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc Natl Acad Sci USA 1993;90:8474-8478.

31. Morishita R, Gibbons GH, Ellison KE, Nakajima M, Leyen HVL, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. Antisense oligonucleotides directed at cell cycle regulatory genes as a target for restenosis therapy. Transactions of Association of American Physicians 1993;106:54-61.

32. Tomita N, Higaki J, Kaneda Y, Yu H, Morishita R, Mikami H, Ogihara T. Hypertensive rats produced by in vivo introduction of the human renin gene. Circulation Research 1993;73:898-905.

33. Yu H, Rakugi H, Higaki J, Morishita R, Mikami H, Ogihara T. The role of activated vascular angiotensin II generation in vascular hypertrophy in one-kidney, one clip hypertensive rats. Journal of Hypertension 1993;11:1347-1355.

34. Morishita R, Gibbons GH, Ellison KE, Nakajima M, Leyen HVL, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. Journal of Clinical Investigation 1994;93:1458-1464.

35. Morishita R, Rakugi H, Higaki J, Tomita N, Nakamura F, Yu H, Katsuya T, Mikami H, Ogihara T. Differential regulation of brain angiotensin II in genetically hypertensive and normotensive rats after nephrectomy. Blood Pressure 1994:3;265-269.

36. Morishita R, Gibbons GH, Pratt E, Tomita N, Kaneda Y, Ogihara T- Dzau VJ. Autocrine and paracrine effects of atrial natriuretic peptide gene transfer on vascular smooth muscle and endothelial cellular growth. Journal of Clinical Investigation 1994;94:824-829.

37. Morishita R, Gibbons GH, Ellison KE, Lee W, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. Evidence for direct local effect of angiotensin in vascular hypertrophy: in vivo gene transfer of angiotensin converting enzyme. Journal of Clinical Investigation 94:978-984,1994.

38. Morishita R, Higaki J, Yu H, Tomita N, Nakamura F, Mikami H, Ogihara T. Effect of antihypertensive drugs on vascular hypertrophy and vascular angiotensin II in two-kidney, one clip hypertensive rats. Journal of Vascular Medicine and Biology 1994;5:38-45.

39. Morishita R., Gibbons GH, Kaneda Y, Ogihara T, Dzau VJ. Pharmacokinetics of antisense oligonucleotides (cyclin B1 and cdc 2 kinase) in the vessel wall: enhanced therapeutic utility for restenosis by HVJ-liposome method. Gene 1994;149:13-19.

40. Katahira K, Mikami H, Otuka A, Moriguchi A, Kohara K, Higashimori K, Okuda N, Nagano M, Morishita R, Ogihara T. Differential control of vascular tone and heart rate by different amino acid neurotransmitters in the rostral ventrolateral medulla of the rat. Clinical and Experimental Physiology and Pharamcology. 1994;21:545-556.

41. Tomita N, Higaki J, Morishita R, Kaneda Y, Ogihara T. A novel gene transfer technique mediated by HVJ (Sendai virus), nuclear protein and liposomes. Cancer Detection and Prevention. 1994;18:485-491.

42. Morishita R, Higaki J, Rakugi H, Tomita N, Yu H, Nakamura F, Mikami H, Ogihara T. Effect of antihypertensive drug on brain angiotensin II level in renal and spontaneously hypertensive rats. Clinical and Experimental Physiology and Pharmacology 1995;22;665-669.

43. Leyen H.V.L., Gibbons G.H., Morishita R., Lewis N.P., Zhang L., Nakajima M., Kaneda Y., Cooke J.P., Dzau V.J. Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of ec-nitric oxide synthase gene. Proc Natl Acad Sci USA 1995;92:1137-1141.

44. Morishita R, Gibbons GH, Horiuchi M, Ellison KE, Nakajima M, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. Proceeding of National Academy of Sciences USA 1995;92:5855-5859.

45. Tomita N, Morishita R, Higaki J, Aoki M, Nakamura Y, Mikami H, Fukamizu A, Murakami K, Kaneda Y, Ogihara T. Transient decrease in high blood pressure by in vivo transfer of antisense oligodeoxynucleotides against rat angiotensinogen. Hypertension 1995;26:131-136.

46. Yamada T, Horiuchi M, Morishita R, Zhang L, Pratt RE, Dzau VJ. In vivo identification of a negative regulatory element in the mouse renin gene using direct gene transfer. Journal of Clinical Investigation 1995;96:1230-1237.

47. Tomita N, Morishita R, Higaki J, Tomita S, Aoki M, Kaneda Y, Ogihara T. Role of angiotensinogen in blood pressure regulation in normotensive rats: application of a �loss of function� approach. Journal of Hypertension 1995;13;1767-1774.

48. Yamada K, Moriguchi A, Mikami H, Higaki J, Morishita R, Aoki M, Okuda N, Ogihara T. Importance of central amino acid neurotransmitter in the blood pressure regulation in the spontaneously hypertensive rat. Journal of Hypertension 1995;13;1624-1630.

49. Nakamura Y, Morishita R, Higaki J, Kida I, Aoki M, Moriguchi A, Yamada K, Hayashi S, Yo Y, Matsumoto K, Nakamura T. Expression of local hepatocyte growth factor system in vascular tissues. Biochemical Biophysics Research Communication 1995;215:483-488.

50. Nakajima M, Hutchinson H, Fujinaga M, Hayashida W, Morishita R, Zhang L, Horiuchi M, Pratt RE, Dzau VJ. The AT2 receptor antagonizes the growth effects of the AT1 receptor: gain of function study using gene transfer. Proceeding of National Academy of Sciences USA 1995;92:10663-10667.

51. Hara S, Morishita R, Tone Y, Yokoyama C, Inoue H, Kaneda Y, Ogihara T, Tanabe T. Overexpression of prostacyclin synthase inhibits growth of vascular smooth muscle cells. Biochemical Biophysics Research Communication 1995;216:862-867.

52. Sawa Y, Suzuki K, Bai HZ, Shirakura R, Morishita R, Kaneda Y, Matsuda H. Efficiency of in vivo gene transfection into transplanted rat heart by coronary infusion of HVJ-liposome. Circulation 1995;92:II-479-482.

53. Ellison KE, Bishopric NH, Webster KA, Morishita R, Gibbson GH, Kaneda Y, Sato B, Dzau VJ, Fusigenic liposome-mediated DNA transfer into cardiac myocytes. Journal of Molecular and Cellular Cardiology 1995;28:1385-1399.

54. Morishita R, Higaki J, Tomita N, Aoki M, Moriguchi A, Tamura K, Murakami K, Kaneda Y, Ogihara T. Role of transcriptional cis-elements, angiotensinogen gene-activating element, of angiotensinogen gene in blood pressure regulation. Hypertension 1996;27:502-507.

55. Hayashi S, Morishita R, Higaki J, Aoki M, Moriguchi A, Kida I, Sawa Y, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T. Autocrine-paracrine effects of over-expression of hepatocyte growth factor gene on growth of endothelial cells. Biochemical Biophysics Research Communication 1996;220:539-545.

56. Tomita N, Morishita R, Higaki J, Tomita S, Aoki M, Ogihara T, Kaneda Y. In vivo gene transfer of insulin gene into neonatal rats by HVJ-liposome method resulted in sustained transgene expression. Gene Therapy 1996:3;477-482.

57. Tomita N, Morishita R, Higaki J, Tomita S, Aoki M, Kaneda Y, Ogihara T. Transfection of renin gene into neonates results in sustained gene expression, but fails to produce sustained hypertension. Biochemical Biophysics Research Communication 1996;224:43-49.

58. Nakamura Y, Morishita R, Higaki J, Kida I, Aoki M, Moriguchi A, Yamada K, Hayashi S, Yo Y, Nakano H, Matsumoto K, Nakamura T, Ogihara T. Hepatocyte growth factor (HGF) ia a novel member of endothelium-specific growth factors: additive stimulatory effect of HGF with basic fibroblast growth factor, but not vascular endothelial growth factor. Journal of Hypertension 1996;14:1067-1072.

59. Yamada K, Moriguchi A, Morishita R, Aoki M, Nakamura Y, Mikami H, Oshima T, Ninomiya M, Kaneda Y, Higaki J, Ogihara T. Efficient oligonucleotides delivery using HVJ-liposome method in the central nervous system. American Journal of Physiology 1996;40:R1212-1220.

60. Nakamura Y, Morishita R, Nakamura S, Aoki M, Moriguchi A, Matsumoto K, Nakamura T, Higaki J, Ogihara T. A vascular modulator, hepatocyte growth factor, is associated with systolic pressure. Hypertension 1996;28:409-413.

61. Hayashi S, Morishita R, Aoki M, Moriguchi A, Kida I, Nakajima M, Kaneda Y, Higaki J, Ogihara T. In vivo transfer of gene and oligodeoxynucleotides into skin of fetal rats by incubation in amniotic fluid. Gene Therapy 1996;3:878-885.

62. Yonemitsu Y, Kaneda Y, Morishita R, Nakagawa K, Nakashima Y, Sueishi K. Characterization of in vivo gene transfer into the arterial wall mediated by the Sendai virus (Hemagglutinating Virus of Japan) liposomes: an effective tool for the in vivo study of arterial diseases. Laboratory Investigation 1996;75:313-323.

63. Morishita R, Gibbons GH, Horiuchi M, Nakajima M, Ellison KE, Lee W, Kaneda Y, Ogihara T, Dzau VJ, Molecular delivery system for antisense olgonucleotides: enhanced effectiveness of antisense oligonucleotides by HVJ-liposome mediated transfer. Journal of Cardiovascular Pharmacology & Therapeutics 1996;2:213-222.

64. Morishita R, Nakamura S, Nakamura Y, Aoki M, Moriguchi A, Kida I, Yo Y, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Potential role of endothelium-specific growth factor, hepatocyte growth factor, on endothelial damage in diabetes mellitus. Diabetes 1997;46:138-142.

65. Aoki M, Morishita R, Higaki J, Moriguchi A, Hayashi S, Matsushita H, Kida I, Tomita N, Sawa Y, Kaneda Y, Ogihara T. Survival of grafts of genetically modified cardiac myocytes transfected with FITC-labeled oligodeoxynucleotides and ?-galactosidase gene in non-infarcted area, but not myocardial infarcted area. Gene Therapy 1997;4:120-127.

66. Aoki M, Morishita R, Higaki J, Moriguchi A, Kida I, Hayashi S, Matsushita H, Kaneda Y, Ogihara T. In vivo transfer efficiency of antisense oligonucleotides into the myocardium using HVJ-liposome method. Biochemical Biophysics Research Communications 1997;231:540-545.

67. Aoki M, Morishita R, Muraishi A, Moriguchi A, Sugimoto T, Maeda K, Dzau VJ, Kaneda Y, Higaki J, Ogihara T. Efficient in vivo gene transfer into heart in rat myocardial infarction model using HVJ (Hemagglutinating Virus of Japan)-liposome method. Journal of Molecular and Cellular Cardiology 1997;29:949-959.

68. Rakugi H, Okamura A, Kamide K, Ohishi M, Sasamura H, Morishita R, Higaki J, Ogihara T. Recognition of tissue- and subtype-specific modulation of angiotensin II receptors using antibodies against AT1 and AT2 receptors. Hypertension Research 1997;20:51-55.

69. Morishita R, Higaki J, Hayashi S, Yo Y, Aoki M, Nakamura S, Moriguchi A, Matsushita H, Matsumoto K, Nakamura T, Ogihara T. Role of hepatocyte growth factor in endothelial regulation: Prevention of high D-glucose-induced endothelial cell death by prostaglandins and phosphodiesterase type 3 inhibitor. Diabetologia 1997;40:1053-1061.

70. Tomita T, Hashimoto H, Tomita N, Morishita R, Bak Lee S, Hayashida K, Nakamura N, Yonenobu K, Kaneda Y, Ochi T. In vivo eirect gene transfer into articular cartilage by intraarticular injection mediated by HVJ (Sendai virus) and liposomes. Arthritis & Rheumatism 1997;40:901-906.

71. Morishita R, Sugimoto T, Aoki M, Kida I, Tomita N, Moriguchi A, Maeda K, Sawa Y, Kaneda Y, Higaki J, Ogihara T. In Vivo Transfection of cis element "decoy" against NFkB binding site prevented myocardial infarction as gene therapy. Nature Medicine 1997;3:894-899.

72. Suzuki J, Isobe M,Morishita R, Aoki M, Horie S, Okubo Y, Kaneda Y, Sawa Y, Matsuda H, Ogihara T, Sekiguchi M. Prevention of graft coronary arteriosclerosis by antisense cdk 2 kinase oligonucleotide. Nature Medicine 1997;3:900-903.

73. Aoki M, Morishita R, Matsushita H, Nakano N, Hayashi S, Tomita N, Yamamoto K, Moriguchi A, Higaki J, Ogihara T. Serum deprivation induced apoptosis accompanied by up-regulation of p53 and bax in human aortic vascular smooth muscle cells. Heart & Vessels 1997;S12:71-75.

74. Sawa Y, Morishita R, Suzuki K, Kagisaki K, Kaneda Y, Maeda K, Kadoba K, Matsuda H. A novel strategy for myocardial protection using in vivo transfection of cis element �decoy� against NFkB binding site: evidence for a role of NFkB in ischemic-reperfusion injury. Circulation 1997;96:II-280-285.

75. Nakano N, Moriguchi A, Morishita R, Kida I, Tomita N, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Role of angiotensin II in the regulation of a novel vascular modulator, hepatocyte growth factor, in experimental hypertensive rats. Hypertension 1997;30:1448-1454.

76. Yo Y, Morishita R, Yamamoto K, Tomita N, Kida I, Hayashi S, Moriguchi A, Kato S, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Actions of Hepatocyte Growth Factor as a Local Modulator in the Kidney: Potential Role in Pathogenesis of Renal Disease. Kidney International 1998;53:50-58.

77. Matsushita H, Morishita R, Kida I, Aoki M, Hayashi S, Tomita N, Yamamoto K, Moriguchi A, Noda A, Kaneda Y, Higaki J, Ogihara T. Inhibition of growth of human vascular smooth muscle cells by over-expression of p21 gene through induction of apoptosis. Hypertension 1998;31:493-498.

78. Matsumoto T, Komori K, Yonemitsu Y, Morishita R, Sueishi K, Kaneda Y, Sugimachi K. Hemagglutinating virus of Japan-liposome mediated gene transfer of endothelial cell nitric oxide synthase inhibits intimal hyperplasia of canine vein grafts under conditions of poor runoff. Journal of Vascular Surgery 1998;27:125-144.

79. Nakamura S, Moriguchi A, Morishita R, Aoki M, Yo Y, Hayashi S, Nakano N, Katsuya T, Nakata S, Takami S, Matsumoto K, Nakamura T, Higaki J, Ogihara T. A novel vascular modulator, hepatocyte growth factor (HGF), as a potential index of the severity of hypertension. Biochemical Biophysics Research Communication 1998;242:238-243

80. Morishita R, Gibbons GH, Horiuchi M, Kaneda Y, Ogihara T, Dzau VJ. Role of AP-1 complex in angiotensin II-mediated transforming growth factor-? expression and growth of smooth muscle cells:using decoy approach against AP-1 binding site. Biochemical Biophysics Research Communication 1998;243:361-367.

81. Hirano T, Fujimoto J, Ueki T, Yamamoto H, Iwasaki T, Morishita R, Sawa Y, Kaneda Y, Takahashi H, Okamoto E. Persistent gene expression in rat liver in vivo by repetitive transfections using HVJ-liposome. Gene Therapy 1998;5:459-464.

82. Ono S, Date I, Onoda K, Shiota T, Ohmoto T, Ninomiya Y, Asari S, Morishita R. Decoy administration of NFkB into the subarachnoid space for cerebral angiopathy. Human Gene Therapy 1998;9:1003-1011.

83. Suzuki J, Isobe M, Morishita R; Aoki M, Yamazaki S, Kaneda Y, Sawa Y, Matsuda H, Ogihara T, Horie S, Okubo Y, Sekiguchi M. Antisense Cdk2 kinase oligodeoxynucleotide inhibits ICAM-1 expression in murine cardiac allograft arteriopathy. Transplant Proc 1998;30:89-90.

84. Tomita N, Morishita R, Tomita S, Yamamoto K, Aoki M, Matsushita H, Hayashi S, Higaki J, Ogihara T. Transcription factor decoy for NFkB inhibits TNF-?-induced IL-6 and ICAM-1 expression in endothelial cells. Journal of Hypertension 1998;16:993-1000.

85. Isobe M, Suzuki J, Morishita R, Aoki M, Amano J, Kaneda Y, Sawa Y, Matsuda H, Ogihara T, Horie S, Okubo Y, Sekiguchi M. Downregulation of endothelin-1 expression in allograft coronary arteries after gene therapy targeting cdk2 kinase. Transplantation Proceedings 1998;30:1007-1008

86. Bai HZ, Morishita R, Kida I, Yamakawa T, Zhang WD, Aoki M, Matsushita H, Noda A, Nagai R, Kaneda Y, Higaki J, Ogihara T, Sawa Y, Matsuda H. Inhibition of intimal hyperplasia after vein grafting by in vivo transfer of human senescent cell-derived inhibitor-1 gene. Gene Therapy 1998;5:761-769.

87. Morishita R, Yamada S, Higaki J, Tomita N, Kida I, Aoki M, Moriguchi A, Hayashi S, Sakurabayashi I, Kaneda Y, Ogihara T. Conditioned medium from HepG2 cells transfected with human apolipoprotein (a) gene stimulates growth of human vascular smooth muscle cells: effects of over-expression of human apolipoprotein (a) gene. Hypertension 1998;32:215-222.

88. Morishita R, Yamamoto K, Yamada S, Matsushita H, Tomita N, Sakurabayashi I, Kaneda Y, Moriguchi A, Higaki J, Ogihara T. Stimulatory effect of lipoprotein (a) on proliferation of human mesangial cells: role of lipoprotein (a) in renal disease. Biochemical Biophysics Research Communication 1998;249:313-320

89. Nakano N, Morishita R, Moriguchi A, Nakamura Y, Hayashi S, Aoki M, Kida I, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Negative regulation of local hepatocyte growth factor (HGF) expression by angiotensin II and transforming growth factor-? in blood vessels: potential role of HGF in cardiovascular disease. Hypertension 1998;32:444-451

90. Yo Y, Morishita R, Nakamura S, Tomita N, Yamamoto K, Moriguchi A, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Potential role of hepatocyte growth factor in the maintenance of renal structure: anti-apoptotic action of HGF on epithelial cells. Kidney International 1998:54:1128-1138

91. Morishita R, Yamada S, Yamamoto K, Tomita N, Kida I, Sakurabayashi I, Kikuchi A, Kaneda Y, Lawn R, Higaki J, Ogihara T. Novel therapeutic strategy for atherosclerosis: ribozyme oligonucleotides against apolipoprotein (a) selectively inhibit apolipoprotein (a), but not plasminogen, gene expression. Circulation 1998;98:1898-1904

92. Sawa Y, Kaneda Y, Bai HZ, Suzuki K, Fujimoto J, Morishita R, Matsuda H. Efficient transfer of oligonucleotides and plasmid DNA into the whole heart through the coronary artery. Gene Therapy 1998;5;1472-1480.

93. Nakamura S, Morishita R, Moriguchi A, Yo Y, Nakamura Y, Hayashi S, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Hepatocyte growth factor as a potential index of complication in diabetes mellitus. Journal of Hypertension 1998;16:2019-2026.

94. Kawamura I, Morishita R, Tomita N, Elizabeth L, Aketa M, Tsujimoto S, Manda T, Tomoi M, Kida I, Higakai J, Kaneda Y, Shimomura K, Ogihara T. Intratumoral injection of oligonucleotides to the NFkB binding site inhibits cachexia in a mouse tumor model. Gene Therapy 1999;6;91-97

95. Ueki T, Kaneda Y, Tsutsui H, Nakanishi K, Sawa Y, Morishita R, Matsumoto K, Nakamura T, Takahashi H, Oakamoto E, Fujimoto J. Curative gene therapy of liver cirrhosis by hepatocyte growth factor in rats. Nature Medicine 1999;5:226-230

96. Todaka T, Yokoyama C, Yanamoto H, Hashimoto N, Nagata I, Tsukahara T, Hara S, Hatae T, Morishita R, Aoki M, Ogihara T, Kaneda Y, Tanabe T. Gene transfer of human prostacyclin synthase prevents neointimal formation after carotid balloon injury in rats. Stroke 1999;30:419-426.

97. Tomita S, Tomita N, Yamada T, Xhang L, Kaneda Y, Morishita R, Ogihara T, Dzau VJ, Horiuchi M. Transcription factor decoy to syudy the molecular mechanism of negative regulation of renin gene expression in the liver in vivo. Circulation Research 1999;84:1059-1066.

98. Morishita R, Nakamura S, Hayashi S, Taniyama Y, Moriguchi A, Nagano T, Taiji M, Noguchi H, Takeshita S, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as �cytokine supplement therapy� Hypertension 1999;33:1379-1384

99. Nishii T, Moriguchi A, Morishita R, Yamada K, Nakamura S, Tomita N, Kaneda Y, Fukamizu A, Mikami H, Higaki J, Ogihara T. Angiotensinogen gene activating elements regulate blood pressure in the brain. Circulation Research 1999;85:257-263.

100. Aoki M, Morishita R, Matsushita H, Hayashi S, Nakagami H, Yamamoto K, Moriguchi A, Kaneda Y, Higaki J, Ogihara T. Inhibition of the p53 tumor suppressor gene resulted in growth of human aortic vascular smooth muscle cells (VSMC): potential role of p53 in regulation of VSMC growth. Hypertension 1999;34:192-200

101. Matsumoto K, Morishita R, Moriguchi A, Tomita N, Yo Y, Nishii T, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Prevention of renal damage by angiotensin II blockade, accompanied by increased renal hepatocyte growth factor in experimental hypertensive rats. Hypertension 1999;34:279-284

102. Nakamura S, Moriguchi A, Morishita R, Yamada K, Nishii T, Tomita N, Oishi M, Kaneda Y, Higaki J, Ogihara T. Activation of the brain angiotensin system by in vivo human angiotensin converting enzyme gene transfer in rats. Hypertension 1999;34:302-308.

103. Zhou WZ, Kaneda Y, Huang SKS, Morishita R, Hoon DSB. Protective immunization against melanoma by gp100 DNA HVJ-liposome vaccine. Gene Therapy 1999;6:1768-1773

104. Yamada S, Inoue K, Morishita R, Ogihara T, Kubono K, Kubo N, Abe A, Sakurabayashi I. A new Lp(a) assay that is unaffected by apo(a) size polymorphism. Clinica Chimica Acta 1999;287:29-43.

105. Suzuki J, Isobe M, Morishita R, Izawa A, Yamazaki S, Okubo Y, Kaneda Y, Sekiguchi M. E2F decoy suppresses E-selectin expression in murine cardiac allograft arteriopathy. Transplant Proc 1999;31:2018-2019

106. Suzuki J, Izawa A, Morishita R, Kaneda Y, Sawa Y, Okubo Y, Ogihara T, Sekiguchi M, Isobe M. Antisense Cdc2 kinase oligonucleotide inhibits adhesion molecule expression in cardiac allograft arteriopathy. Transplant Proc 1999;31:955-956

107. Suzuki J, Izawa A, Morishita R, Kaneda Y, Sawa Y, Okubo Y, Ogihara T, Sekiguchi M, Isobe M. Prevention of cardiac allograft arteriopathy by antisense Cdc2 kinase oligonucleotide. Transplant Proc 1999;31:867-868

108. Hayashi S, Morishita R, Nakamura S, Yamamoto K, Moriguchi A, Nagano T, Taizi M, Noguchi H, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Potential role of hepatocyte growth factor, a novel angiogenic growth factor, in peripheral arterial disease: down-regulation of HGF in response to hypoxia in vascular cells. Circulation 1999;100:II301-II308.

109. Zhou WZ, Hoon DSB, Huang SKS, Fujii S, Hashimoto K, Morishita R, Kaneda Y. RNA melanoma vaccine: induction of anti-tumor immunity by human gp100 mRNA immunization. Human Gene Therapy 1999;10:2719-2724

110. Tomita T, Takeuchi E, Tomita N, Morishita R, Kaneko M, Yamamoto K, Nakase T, Seki H, Kato K, Kaneda Y, Ochi T. Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy. Arthritis Rheum 1999;42:2532-2542

111. Hayashi Si, Morishita R, Matsushita H, Nakagami H, Taniyama Y, Nakamura T, Aoki M, Yamamoto K, Higaki J, Ogihara T. Cyclic AMP Inhibited Proliferation of Human Aortic Vascular Smooth Muscle Cells, Accompanied by Induction of p53 and p21. Hypertension 2000;35:237-243

112. Higaki J, Aoki M, Morishita R, Kida I, Taniyama Y, Tomita N, Yamamoto K, Moriguchi A, Kaneda Y, Ogihara T. In vivo evidence of importance of cardiac angiotensin converting enzyme in the pathogenesis of cardiac hypertrophy. Arteriosclerosis, Thrombosis & Vascular Biology 2000;20:428-434.

113. Suzuki J, Isobe M, Morishita R, Nishikawa T, Amano J, Kaneda Y. Antisense bcl-x oligonucleotide induces apoptosis and prevents arterial neointimal formation in murine cardiac allografts. Cardiovascular Research 2000;45:783-787.

114. Kaneda Y, Saeki Y, Nakabayashi M, Zhou WZ, Wataya-Kaneda M, Morishita R. Enhancement of transgene expression by cotransfection of oriP plasmid with EBNA-1 expression vector. Human Gene Therapy 2000;11:471-479.

115. Aoki M, Morishita R, Taniyama Y, Kida I, Moriguchi A, Matsumoto K, Nakamura T, Kaneda Y, Higaki J, Ogihara T. Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infarcted myocardium: up-regulation of essential transcription factor for angiogenesis, ets. Gene Therapy 2000;7:417-427

116. Suzuki K, Nakashima H, Sawa Y, Morishita R, Matsuda H, Kaneda Y. Reconstituted fusion liposomes for gene transfer in vitro and in vivo. Gene Therapy & Regulation. 2000;1:65-77.

117. Morishita R, Gibbons GH, Tomita N, Zhang L, Kaneda Y, Ogihara T, Dzau VJ. Antisense oligodeoxynucleotide inhibition of vascular angiotensin converting enzyme expression attenuates neointimal formation: evidence for tissue ACE function. Arteriosclerosis, Thrombosis & Vascular Biology 2000;20:915-922.

118. Matsushita H, Morishita R, Aoki M, Tomita N, Taniyama Y, Nakagami H, Shimozato T, Higaki J, Kaneda Y, Ogihara T. Transfection of antisense p53 tumor suppressor gene oligodeoxynucleotides into rat carotid artery resulted in abnormal growth of vascular smooth muscle cells. Circulation 2000;101:1447-1452

119. Matsushita H, Morishita R, Nata T, Aoki M, Nakagami H, Taniyama Y, Yamamoto K, Higaki J, Kaneda Y, Ogihara T. Hypoxia induced endothelial apoptosis through NFkB-mediated bcl-2 suppression: in vivo evidence of importance of NFkB in endothelial cell regulation. Circulation Research 2000;86:974-981

120. Yamano H, Ura K, Morishita R, Nakajima H, Monden M, Kaneda Y. Amplification of transgene expression in vitro and in vivo using a novel inhibitor of histone deacteylase. Molecular Therapy 2000;1:574-580.

121. Taniyama Y, Morishita R, Nakagami H, Moriguchi A, Sakonjo H, Kim S, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Potential contribution of a novel anti-fibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamster. Circulation 2000;102:246-252

122. Tomita N, Morishita R, Lan HY, Yamamoto K, Hashizume M, Notakae M, Toyosawa K, Fujitani B, Mu W, Nikolic-Paterson DJ, Atkins RC, Kaneda Y, Higaki J, Ogihara T. In vivo administration of a nlear transcription factor-kappaB decoy suppresses experimental crescentic glomerulonephritis. Journal of American Society of Nephrology 2000;11:1244-1252

123. Morishita R, Gibbons GH, Kaneda Y, Ogihara T, Dzau VJ. Systemic administration of HVJ viral coat-liposome complex containing human insulin vector decreases glucose level in diabetic mouse: a model of gene therapy. Biochemical Biophysics Research Communication 2000;273:666-674

124. Tomita T, Takano H, Tomita N, Morishita R, Kaneko M, Shi K, Takahi K, Nakase T, Kaneda Y, Yoshikawa H, Ochi T. Transcription factor decoy for nuclear factor kappaB inhibits cytokine and adhesion molecule expressions in synovial cells derived from rheumatoid arthritis. Rheumatology 2000;39:749-757

125. Tomita N, Morishita R, Tomita S, Gibbons GH, Zhang L, Horiuchi M, Kaneda Y, Higaki J, Ogihara T, Dzau VJ. Transcription factor decoy for NFkB inhibits TNF-?-induced cytokine and adhesion molecule expression in vivo. Gene Therapy 2000;7:1326-1332

126. Yamamoto K, Morishita R, Tomita N, Shimozato T, Nakagami H, Kikuchi A, Aoki M, Higaki J, Kaneda Y, Ogihara T. Ribozyme oligonucleotides against transforming growth factor-? inhibited neointimal formation after vascular injury in rat model: potential application of ribozyme strategy to treat cardiovascular disease. Circulation 2000;102:1308-1314

127. Kitamoto S, Egashira K, Kataoka C, Koyanagi M, Katoh M, Shimokawa H, Morishita R, Kaneda Y, Sueishi K, Takeshita A. Increased activity of nuclear factor-kappaB participates in cardiovascular remodeling induced by chronic inhibition of nitric oxide synthesis in rats. Circulation. 2000;102:806-812.

128. Egashira K, Koyanagi M, Kitamoto S, Ni W, Kataoka C, Morishita R, Kaneda Y, Akiyama C, Nishida K, Takeshita A. Anti-monocyte chemoattractant protein-1 gene therapy inhibits vascular remodeling in rats. FASEB Journal 2000;14:1974-1978

129. Suzuki J, Isobe M, Morishita R, Nishikawa T, Amano J, Kaneda Y. Prevention of cardiac allograft arteriosclerosis using antisense proliferating-cell nuclear antigen oligonucleotide. Transplantation 2000;70:398-400

130. Morishita R. Adventure of gene therapy into the brain: a new era for cardiovascular gene therapy (Editorial). Circulation research 2000;87:719-721.

131. Nakagami H, Morishita R, Yamamoto K, Taniyama Y, Aoki M, Kim S, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Anti-apoptotic action of hepatocyte growth factor (HGF) through mitogen-activated protein kinase on human aortic endothelial cells. Journal of Hypertension 2000;18:1411-1420

132. Hayashi K, Nakamura S, Morishita R, Moriguchi A, Aoki M, Matsumoto K, Nakamura T, Kaneda Y, Sakai N, Ogihara T. In vivo transfer of human hepatocyte growth factor gene accelerates re-endothelialization and inhibits neointimal formation after balloon injury in rat model. Gene Therapy 2000;7:1664-1671

133. Suzuki J, Morishita R, Amano J, Kaneda Y, Isobe M. Decoy against nuclear factor-kappa B attenuates myocardial cell infiltration and arterial neointimal formation in murine cardiac allografts. Gene Therapy 2000;7:1847-1852.

134. Yamada S, Morishita R, Nakamura S, Ogihara T, Kusumi Y, Sakurai I, Kubo N, Sakurabayashi I. Development of antibody against epitope of lipoprotein (a) modified by oxidation: evaluation of new enzyme-linked immunoassay for oxidized Lp (a). Circulation 2000;102:1639-1644.

135. Nagaya N, Yokoyama C, Kyotani S, Shimonishi M, Morishita R, Uematsu M, Nishikimi T, Nakanishi N, Ogihara T, Yamagishi M, Miyatake K, Kaneda Y, Tanabe T. Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats. Circulation 2000;102:2005-2010.

136. Hayashi I, Majima M, Fujita T, Okumura T, Kumagai Y, Tomita N, Morishita R, Higaki J, Ogihara T. In vivo transfer of antisense oligonucleotide against urinary kininase blunts deoxycorticosterone acetate-salt hypertension in rats. Br J Pharmacol. 2000;131:820-826.

137. Kawauchi M, Suzuki J, Morishita R, Wada Y, Izawa A, Tomita N, Amano J, Kaneda Y, Ogihara T, Takamoto S, Isobe M. Gene Therapy for attenuating cardiac allograft arteriopathy using ex vivo E2F decoy transfection by HVJ-AVE-liposome method in mice and nonhuman primates. Circulation Research 2000;87:1063-1068

138. Okada M, Hojo Y, Ikeda U, Takahashi M, Takizawa T, Morishita R, Shimada K. Interaction between monocytes and vascular smooth muscle cells induces expression of hepatocyte growth factor. J Hypertens. 2000;18:1825-1831.

139. Shinmura K, Morishita R, Aoki M, Higaki J, Ogihara T, Kaneda Y, Tani M. Catheter-delivered in vivo gene transfer into rat myocardium using the fusigenic liposomal mediated method. Jpn Heart J. 2000;41:633-647.

140. Sugimoto T, Mine H, Horii Y, Takahashi K, Nagai R, Morishita R, Komada M, Asada Y, Sawada T. Neuroblastoma cell lines showing smooth muscle cell phenotypes. Diagn Mol Pathol. 2000;9:221-228.

141. Higaki J, Katsuya T, Morishita R, Ogihara T. Hypertension and Genes. Internal Medicine. 2001;40:144-147.

142. Nakagami H, Morishita R, Yamamoto K, Taniyama Y, Aoki M, Matsumoto K, Nakamura T, Kaneda Y, Horiuchi M, Ogihara T. Mitogenic and anti-apoptotic actions of HGF through ERK, STAT3 and Akt in endothelial cells. Hypertension 2001;37:581-586

143. Matsumoto K, Morishita R, Moriguchi A, Tomita N, Aoki M, Sakonjo H, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Inhibition of neointima by ACE inhibitor in porcine coronary artery balloon injury model. Hypertension 2001;37:270-274

144. Tomita N, Morishita R, Higaki J, Ogihara T. Novel molecular therapeutic approach to cardiovascular disease based on hepatocyte growth factor. Journal of Atherosclerosis and Thrombosis. 2001;7:1-7.

145. Aoki M, Morishita R, Taniyama Y, Kaneda Y, Ogihara T. Therapeutic angiogenesis induced by hepatocyte growth factor: potential gene therapy for ischemic diseases. Journal of Atherosclerosis and Thrombosis. 2001;7:71-76.

146. Taniyama Y, Morishita R, Aoki M, Nakagami H, Yamamoto K, Yamazaki K, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T. Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hind limb ischemia models: preclinical study for treatment of peripheral arterial disease. Gene Therapy 2001;8:181-189

147. Tsuboniwa N, Morishita R, Hirano T, Fujimoto J, Furukawa S, Kikumori M, Okuyama A, Kaneda Y. Safety evaluation of hemagglutinating virus of japan-artificial viral envelope liposomes in nonhuman primates. Hum Gene Ther. 2001;12:469-487.

148. Kawauchi M, Suzuki J, Wada Y, Morishita R, Kaneda Y, Isobe M, Amano J, Takamoto S. Downregulation of nuclear factor kappa B expression in primate cardiac allograft arteries after E2F decoy transfection. Transplant Proc. 2001;33:451.

149. Tomita N, Morishita R, Tomita S, Kaneda Y, Higaki J, Ogihara T, Horiuchi M. Inhibition of TNF-alpha, induced cytokine and adhesion molecule. expression in glomerular cells in vitro and in vivo by transcription factor decoy for NFkappaB. Experimental Nephrology. 2001;9:181-190

150. Yamamoto K, Morishita R, Hayashi S, Matsushita H, Nakagami H, Moriguchi A, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T. Contribution of Bcl-2. but not Bcl-xL and Bax, to anti-apoptotic actions of hepatocyte growth factor in hypoxic conditioned human endothelial cells. Hypertension 2001;37:1341-1348.

151. Nakagami H, Morishita R, Yamamoto K, Yoshimura S, Taniyama Y, Aoki M, Matsubara H, Kim S, Kaneda Y, Ogihara T. Phosphorylation of p38MAP kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cells. Diabetes 2001;50:1472-1481.

152. Kawamura I, Morishita R (equal first author), Tsujimoto S, Manda T, Tomoi M, Tomita N, Goto T, Ogihara T, Kaneda Y. Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice. Gene Therapy 2001;8:905-912.

153. Sakaue G, Shimaoka M, Fukuoka T, Hiroi T, Inoue T, Hashimoto N, Sakaguchi T, Sawa Y, Morishita R, Kiyono H, Noguchi K, Mashimo T. NF-kappaB decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model. Neuroreport. 2001;12:2079-2084.

154. Ahn JD, Morishita R, Kaneda Y, Lee KU, Park JY, Jeon YJ, Song HS, Lee IK, Transcription factor decoy DON for activator protein-1 (AP-1 inhibits expression of type 1 plasminogen activator inhibitor (PAI-1) gene induced by high glucose and angiotensin II in cultured human vascular smooth muscle cells. Diabetologia 2001;44:713-720.

155. Izumi Y, Kim S, Namba M, Yasumoto H, Miyazaki H, Hoshiga M, Kaneda Y, Morishita R, Zhan Y, Iwao H. Gene transfer of dominant-negative mutants of extracellular signal-regulated kinase and c-Jun NH2-terminal kinase prevents neointimal formation in balloon-injured rat artery. Circ Res. 2001;88:1120-1126.

156. Taniyama Y, Ito H, Morishita R, Ogihara T. Potential of microvascular reperfusion with adjunctive pharmacological intervention: its impact on myocardial perfusion and functional outcomes in patients with acute myocardial infarction. Drugs. 2001;61:437-441.

157. Aoki M, Nata T, Morishita R, Matsushita H, Nakagami H, Yamamoto K, Yamazaki K, Nakabayashi M, Ogihara T, Kaneda Y. Endothelial apoptosis induced by oxidative stress through activation of NFkB: anti-apoptotic effect of antioxidant agents on endothelial cells. Hypertension 2001;38:48-55

158. Hayashi K, Morishita R, Nakagami H, Yoshimura S, Hara A, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T, Sakai N. Gene therapy for preventing neuronal death using hepatocyte growth factor: in vivo gene transfer of HGF to subarachnoid space prevents delayed neuronal death in gerbil hippocampal CA1 neurons. Gene Therapy 2001;8:1167-1173

159. Otomo T. Yamamoto S, Morishita R, Kaneda Y. EBV replicon vector system enhances transgene expression in vivo: applications to gene therapy for cancer. The Journal of Gene Medicine. 2001;3:345-352

160. Sakaue G, Shimaoka M, Fukuoka T, Hiroi T, Inoue T, Hashimoto N, Sakaguchi T, Sawa Y, Morishita R, Kiyono H, Noguchi K, Mashimo T. NFkB decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic model. Somatosensory Systems, Pain. 2001;12:2079-2084

161. Aoki M, Morishita R, Hayashi SI, Jo N, Matsumoto K, Nakamaura T, Kaneda Y, Ogihara T. Inhibition of neointimal formation after balloon injury by cilostazol, accompanied by improvement of endothelial dysfunction and induction of hepatocyte growth factor in rat diabetes model. Diabetologia 2001;44:1034-1042

162. Taniyama Y, Morishita R, Hiraoka K, Aoki M, Nakagami H, Yamasaki K, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T. Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model: molecular mechanisms of delayed angiogenesis in diabetes. Circulation 2001;104:2344-2350.

163. Yokoseki O, Suzuki Ji J, Kitabayashi H, Watanabe N, Wada Y, Aoki M, Morishita R, Kaneda Y, Ogihara T, Futamatsu H, Kobayashi Y, Isobe M. cis Element Decoy Against Nuclear Factor-kappaB Attenuates Development of Experimental Autoimmune Myocarditis in Rats. Circ Res. 2001;89:899-906.

164. Ueno T, Sawa Y, Kitagawa-Sakakida S, Nishimura M, Morishita R, Kaneda Y, Kohmura E, Yoshimine T, Matsuda H. Nuclear factor-kappaB decoy attenuates neuronal damage after global brain ischemia: A future strategy for brain protection during circulatory arrest. J Thorac Cardiovasc Surg. 2001;122:720-727.

165. Yoshimura S, Morishita R, Hayashi K, Yamamoto K, Nakagami H, Kaneda Y, Sakai N, Ogihara T. Inhibition of intimal hyperplasia after balloon injury in rat carotid artery model using cis-element "decoy" of nuclear factor-kB binding site as a novel molecular strategy. Gene Therapy 2001;8:1635-1642

166. Miyata T, Yamamoto S, Sakamoto K, Morishita R, Kaneda Y. Novel immunotherapy for peritoneal dissemination of murine colon cancer with macrophage inflammatory protein-1b mediated by a tumor-specific vector, HVJ catinonic liposomes. Cancer Gene Therapy 2001;8:852-860

167. Tsuchikane E, Nakamura T, Yamasaki K, Kobayashi T, Ptsuji S, Kobayashi T, Morishita R, Awata N. Correlation between serum hepatocyte growth factor level and percutaneous coronary balloon angioplasty: an alternative mechanisms of reduction in restenosis with cilostazol. International Journal of Angiology. 2001;10:270-274..

168. Namiki M, Kawashima S, Yamashita T, Ozaki M, Hirase T, Ishida T, Inoue N, Hirata Ki K, Matsukawa A, Morishita R, Kaneda Y, Yokoyama M. Local overexpression of monocyte chemoattractant protein-1 at vessel wall induces infiltration of macrophages and formation of atherosclerotic lesion: synergism with hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2002;22:115-120.

169. Yasumoto H, Kim S, Zhan Y, Miyazaki H, Hoshiga M, Kaneda Y, Morishita R, Iwao H. Dominant negative c-Jun gene transfer inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in rats. Gene Therapy 2002;8:1682-1689.

170. Taniyama Y, Tachibana K, Hiraoka K, Namba T, Yamasaki K, Hashiya N, Aoki M, Ogihara T, Kaneda Y, Morishita R. Local delivery of plasmid DNA into rat carotid artery using ultrasound. Circulation 2002;105:1233-1239.

171. Morishita R, Sakaki M, Yamamoto K, Iguchi S, Aoki M, Yamasaki K, Matsumoto K, Nakamura T, Lawn R, Ogihara T, Kaneda Y. Impairment of collateral formation in Lp(a) transgenic mice: therapeutic angiogenesis induced by human hepatocyte growth factor gene. Circulation 2002;105:1491-1496

172. Taniyama Y, Tachibana K, Hiraoka K, Aoki M, Yamamoto S, Matsumoto K, Nakamura T, Ogihara T, Kaneda Y, Morishita R. Development of safe and efficient novel non-viral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle. Gene Therapy 2002;9:372-380.

173. Nakamura T, Morishita R, Asai T, Tsuboniwa N, Aoki M, Sakonjo H, Yamasaki K, Hashiya N, Kaneda Y, Ogihara T. Molecular strategy using cis-element �decoy� of E2F binding site inhibits neointimal formation in porcine balloon-injured coronary artery model. Gene Therapy 2002;9:488-494

174. Endoh M, Koibuchi N, Sato M, Morishita R, Kanzaki T, Murata Y, Kaneda Y. Fetal gene transfer by intrauterine injection with microbubble-enhanced ultrasound. Molecular Therapy 2002;5:501-508

175. Mori M, Nakagami H, Morishita R, Mitsuda N, Yamamoto K, Yoshimura S, Ohkubo N, Sato N, Ogihara T, Kaneda Y. N1411 mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression. Life Sciences 2002;70:2567-2580.

176. Yoshimura S, Morishita R, Hayashi K, Kokuzawa J, Aoki M, Matsumoto K, Nakamura T, Ogihara T, Kaneda Y, Sakai N. Gene transfer of hepatocyte growth factor to subarachnoid space in cerebral hypoperfusion model. Hypertension 2002;39:1028-1034

177. Komai N, Ohishi M, Morishita R, Moriguchi A, Kaibe M, Matsumoto K, Rakugi H, Higaki J, Ogihara T. Serum hepatocyte growth factor concentration is correlated with the forearm vasodilator response in hypertensive patients. American Journal of Hypertension 2002;15:499-506

178. Ahn JD, Morishita R, Kaneda Y, Lee SJ, Kwon KY, Choi SY, Lee KU, Park JY, Moon IJ, Park JG, Yoshizumi M, Ouchi Y, Lee IK. Inhibitory Effects of Novel AP-1 Decoy Oligodeoxynucleotides on Vascular Smooth Muscle Cell Proliferation In Vitro and Neointimal Formation In Vivo. Circ Res. 2002;90:1325-1332.

179. Tomita N, Morishita R, Koike H, Hashizume M, Notake M, Fujitani B, Kaneda Y, Horiuchi M, Ogihara T. Therapeutic approach to familial hypercholesterolemia by HVJ-liposomes in LDL receptor knockout mouse. International Journal of Molecular Medicine 2002;10:137-143

180. Taniyama Y, Morishita R, Aoki M, Hiraoka K, Yamasaki K, Hashiya N, Matasumoto K, Nakamura T, Kaneda Y, Ogihara T. Angiogensis and anti-fibrotic action by hepatocyte growth factor in cardiomyopathic hamster. Hypertension 2002;40:47-53

181. Nakagami H, Morishita R, Yamamoto K, Taniyama Y, Aoki M, Yamasaki K, Matasumoto K, Nakamura T, Kaneda Y, Ogihara T. Hepatocyte growth factor (HGF) prevents endothelial cell death through inhibition of bax translocation from cytosol to mitochondrial membrane. Diabetes 2002;51:2604-2611.

182. Kaneda Y, Nakajima T, Nishikawa T, Yamamoto S, Ikegami H, Suzuki N, Nakamura H, Morishita R, Kotani T. Hemagglutinating Virus of Japan (HVJ) envelope vector as a versatile gene delivery system Molecular Therapy 2002;6:219-226.

183. Tomita N, Morishita R, Yamamoto K, Higaki J, Dzau VJ, Ogihara T, Kaneda Y. Targeted gene therapy for rat glomerulonephritis using HVJ-immunoliposomes. Journal of Gene Medicine. 2002;4:527-535

184. Nakamura H, Aoki M, Tamai K, Oishi M, Ogihara T, Kaneda Y, Morishita R. Prevention and regression of atopic dermatitis by ointment containing NF-kB decoy oligodeoxynucleotides in NC/Nga atopic mouse model. Gene Therapy 2002;9:1221-1229

185. Komai N, Morishita R, Yamada S, Ohishi M, Iguchi S, Aoki M, Sakaki M, Sakurabayashi I, Higaki J, Ogihara T. Mitogenic activity of oxidized lipoprotein (a) on human vascular smooth muscle cells. Hypertension 2002;40:310-314

186. Nakanishi K, Uenoyama M, Tomita N, Morishita R, Kaneda Y, Ogihara T, Matsumoto K, Nakamura T, Maruta A, Matsuyama S, Kawai T, Aurues T, Hayashi T, Ikeda T. Gene transfer of human hepatocyte growth factor into rat skin wounds mediated by liposomes coated with the sendai virus (hemagglutinating virus of Japan). American Journal of Pathology. 2002;161:1761-1772.

187. Matsumoto K, Morishita R, Tomita N, Moriguchi A, Yamasaki K, Aoki M, Matasumoto K, Nakamura T, Higaki J, Ogihara T. Impaired endothelial dysfunction in diabetes mellitus rats was restored by oral administration of prostaglandin I2 analogue, accompanied by increase in vascular hepatocyte growth factor. Journal of Endocrinology 2002;175:217-223

188. Morishita R, Gibbons GH, Kaneda Y, Zhang L, Ogihara T, Dzau VJ. Apolipoprotein E-deficient mice created by systemic administration of antisense oligodeoxynucleotides: a new model for lipoprotein metabolism studies. Journal of Endocrinology 2002;175:475-485

189. Ahn JD, Morishita R, Kaneda Y, Kim HS, Chang YC, Lee KU, Park JY, Lee HW, Kim YH, Lee IK. Novel E2F decoy oligodeoxynucleotides inhibit in vitro vascular smooth muscle cell proliferation and in vivo neointimal hyperplasia. Gene Ther. 2002;9:1682-1692.

190. Tsukioka K, Suzuki J, Fujimori M, Wada Y, Yamaura K, Ito K, Morishita R, Kaneda Y, Isobe M, Amano J. Expression of matrix metalloproteinases in cardiac allograft vasculopathy and its attenuation by anti MMP-2 ribozyme gene transfection. Cardiovasc Res. 2002;56:472-478.

191. Jo N, Ogata N, Aoki M, Otsuji T, Morishita R, Kaneda Y, Matsumura M. Effective transfection of a cis element "decoy" of the nuclear factor-kappaB binding site into the experimental choroidal neovascularization. Curr Eye Res. 2002;24:465-473.

192. Shimamura M, Morishita R, Endoh M, Oshima K, Aoki M, Waguri S, Uchiyama Y, Kaneda Y. HVJ-envelope vector for gene transfer into central nervous system. Biochemical Biophysics Research Communications 2003;300:464-471

193. Azuma H, Tomita N, Kaneda Y, Koike H, Ogihara T, Katsuoka Y, Morishita R. Transfection of NF?B decoy oligodeoxynucleotides using efficient ultrasound-mediated gene transfer into donor kidneys prolonged survival of rat renal allografts. Gene Therapy 2003;10:415-425

194. Yamasaki K, Asai T, Shimizu M, Aoki M, Hashiya N, Sakonjo H, Makino H, Kaneda Y, Ogihara T, Morishita R. Inhibition of NF?B activation using cis-element "decoy" of NF?B binding site reduces neointimal formation in porcine balloon-injured coronary artery model. Gene Therapy 2003;10:356-364.

195. Koike H, Morishita R, Iguchi S, Aoki M, Matsumoto K, Nakamura T, Yokoyama C, Tanabe T, Ogihara T, Kaneda Y. Enhanced angiogenesis and improvement of neuropathy by co-transfection of human hepatocyte growth factor and prostacyclin synthase gene. The FASEB Journal 2003;17:779-781

196. Sekiguchi K, Yasuzumi F, Morishita R. Exogenous expression of hepatocyte growth factor (HGF) in rat striatum by naked plasmid DNA. Neuroscience Research 2003;45:173-180

197. Nakabayashi M, Morishita R, Nakagami H, Kuba K, Matasumoto K, Nakamura T, Kamei M, Tano Y, Kaneda Y. HGF/NK4 inhibited VEGF-induced angiogenesis in in vitro cultured endothelial cells and in vivo rabbit model. Diabetologia 2003;46:115-123

198. Matsumoto K, Morishita R, Tomita N, Moriguchi A, Komai N, Aoki M, Matasumoto K, Nakamura T, Higaki J, Ogihara T. Improvement of endothelial dysfunction by angiotensin II blockade, accompanied by induction of vascular hepatocyte growth factor system in diabetic spontaneously hypertensive rats. Heart & Vessels 2003;18:18-25

199. Yamamoto S, Yamano T, Tanaka M, Hoon D.S.B., Takao S, Morishita R, Aikou T, Kaneda Y. A novel combination of suicide gene therapy and histone deacetylase inhibitor for treatment of malignant melanoma. Cancer Gene Therapy. 2003;10:179-186.

200. Tomita N, Morishita R, Taniyama Y, Koike H, Aoki M, Shimizu H, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T. Angiogenic property of hepatocyte growth factor is dependent on up-regulation of essential transcription factor for angiogenesis, ets-1. Circulation 2003;107:1411-1417

201. Kato N, Nakanishi K, Nemoto K, Morishita R, Kaneda Y, Uenoyama M, Ikeda T, Fujikawa K. Efficient gene transfer from innervated muscle into rat peripheral and central nervous systems using a non-viral hemaggultinating virus of Japan (HVJ)-liposome method. Journal of Neurochemistry 2003;85:810-815.

202. Ogushi I, Iimuro Y, Seki E, Son G, Hirano T, Hada T, Tsutsui H, Nakanishi K, Morishita R, Kaneda Y, Fujimoto J. Nuclear factor kappa B decoy oligodeoxynucleotides prevent endotoxin-induced fatal liver failure in a murine model. Hepatology. 2003;38:335-344

203. Lan HY, Mu W, Tomita N, Morishita R, Yu XQ, Li JH, Zhu HJ, Huang XR, Johnson RJ. Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. Journal of American Society of Nephrology 2003;14:1535-1548.

204. Namba T, Koike H, Murakami K, Aoki M, Makino H, Hashiya N, Ogihara T, Kaneda Y, Kohno M, Morishita R. Angiogenesis induced by endothelial nitric oxide synthase gene through VEGF expression in rat hindlimb ischemia model. Circulation 2003;108:2250-2257

205. Hiraoka K, Koike H, Yamamoto S, Tomita N, Yokoyama C, Tanabe T, Aikou T, Ogihara T, Kaneda Y, Morishita R. Enhanced therapeutic angiogenesis by co-transfection of prostacyclin synthase gene or optimization of intramuscular injection of naked plasmid DNA. Circulation 2003;108:2689-2696.

206. Kokuzawa J, Yoshimura S, Kitajima H, Shinoda J, Kaku Y, Iwama T, Morishita R, Shimazaki T, Okano H, Kunisada T, Sakai N. Hepatocyte growth factor promotes proliferation and neuronal differentiation of neural stem cells from mouse embryos. Mol Cell Neurosci. 2003;24:190-197.

207. Wada Y, Fujimori M, Suzuki J, Tsukioka K, Ito K, Sawa Y, Morishita R, Kaneda Y, Isobe M, Amano J. Egr-1 in vascular smooth muscle cell proliferation in response to allo-antigen. J Surg Res. 2003;115:294-302.

208. Nakashima H, Aoki M, Miyake T, Kawasaki T, Iwai M, Jo N, Oishi M, Kataoka K, Ohigi S, Ogihara T, Kaneda Y, Morishita R. Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of NFkB and ets transcription factors. Circulation 2004;109:132-138

209. Ohtani K, Egashira K, Usui M, Ishibashi M, Hiasa KI, Zhao Q, Aoki M, Kaneda Y, Morishita R, Takashita A. Inhibition of neointimal hyperplasia after balloon injury by cis-element �decoy� of early growth response gene-1 in hypercholesterolemic rabbits. Gene Therapy 2004;11:126-132.

210. Namiki M, Kawashima S, Yamashita T, Ozaki M, Sakoda T, Inoue N, Hirata K, Morishita R, Kaneda Y, Yokoyama M. Intramuscular gene transfer of interleukin-10 cDNA reduces atherosclerosis in apolipoprotein E-knockout mice. Atherosclerosis. 2004;172:21-29.

211. Shimamura M, Sato N, Oshima K, Aoki M, Kurinami H, Waguri S, Uchiyama Y, Ogihara T, Kaneda Y, Morishita R. A novel therapeutic strategy to treat brain ischemia: over-expression of hepatocyte growth factor gene rischemic injury without cedema in rat model. Circulation 2004;109:424-431

212. Oshima K, Shimamura M, Mizuno S, Tamai K, Doi K, Morishita R, Nakamura T, Kubo T, Kaneda Y. Intrathecal injection of HVJ-E containing HGF gene to cerebrospinal fluid can prevent and ameliorate hearing impairment in rats. FASEB J. 2004;18:212-214.

213. Matsuki A, Yamamoto S, Nakagami H, Aoki M, Tamai K, Matsumoto K, Nakamura T, Ogihara T, Kaneda Y, Morishita R. No influence of tumor growth by intramuscular injection of hepatocyte growth factor plasmid DNA: safety evaluation of therapeutic angiogenesis gene therapy in mice. Biochemical Biophysical Research Communications. 2004;315:59-65

214. Makino H, Aoki M, Hashiya N, Yamasaki K, Hiraoka K, Shimizu H, Azuma J, Kurinami H, Ogihara T, Morishita R. Increase in peripheral blood flow by intravenous administration of prostaglandin E1 in patients with peripheral arterial disease, accompanied by up-regulation of hepatocyte growth factor (HGF). Hypertension Research 2003;27:85-91

215. Suzuki J, Ito H, Gotoh R, Morishita R, Egashira K, Isobe M. Initial clinical cases using an NF-kB decoy at the site of the coronary stenting for prevention of restenosis. Circulation Journal 2004;68:270-271

216. Koibuchi N, Kaneda Y, Taniyama Y, Matsumoto K, Nakamura T, Ogihara T, Morishita R. Essential role of HGF (hepatocyte growth factor) in blood formation in Xenopus. Blood 2004;103:3320-3325

217. Hashiya N, Aoki M, Tachibana K, Taniyama Y, Yamasaki K, Hiraoka K, Makino H, Kaneda Y, Ogihara T, Morishita R. Local delivery of E2F decoy oligodeoxynucleotides using ultrasound with microbubble agent (Optison) inhibits intimal hyperplasia after balloon injury in rat carotid artery model. Biochemical Biophysical Research Communications. 2004;317:508-514.

218. Nakagami H, Morishita R, Nishikawa T, Shimizu H, Iguchi S, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T. Anti-apoptotic action of bag-1 was not related to HGF receptor, c-met, in endothelial cells. Hypertension Research 2004;27:359-365

219. Wada Y, Fujimori M, Suzuki J, Tsukioka K, Ito K, Sawa Y, Morishita R, Kaneda Y, Isobe M, Amano J. Egr-1 in vascular smooth muscle cell proliferation in response to allo-antigen. Journal of Surgical Research. 2004;115:293-302.

220. Hashiya N, Jo N, Aoki M, Matsumoto K, Nakamura K, Sato Y, Ogata N, Ogihara T, Kaneda Y, Morishita R. In vivo evidence of angiogenesis induced by transcription factor, ets-1: ets-1 is located upstream of angiogenesis cascade. Circulation 2004;109:3035-3041

221. Morishita R, Aoki M, Hashiya N, Makino H, Yamasaki K, Azuma J, Sawa Y, Matsuda H, Kaneda Y, Ogihara T. Safety evaluation of clinical gene therapy using hepatocyte growth factor to treat peripheral arterial disease by therapeutic angiogenesis. Hypertension 2004;44:203-209

222. YamamotoK, Tomita N, Yoshimura S, Nakagami H, Taniyama Y, Yamasaki K, Ogihara T, Morishita R. Hypoxia-induced renal epithelial cell death thourgh caspase-dependent pathway: role of bcl-2, bcl-xL and bax in tubular injury. International Journal of Molecular Medicine. 2004;14:633-640.

223. Yamaura K, Ito K, Tsukioka K, Wada Y, Makiuchi A, Sakaguchi M, Akashima T, Fujimoto M, Sawa Y, Morishita R, Matsumoto K, Nakamura T, Suzuki J, Amano J, Isobe M. Suppression of acute and chronic rejection by hepatocyte growth factor in a murine model of cardiac transplantation: induction of tolerance and prevention of cardiac allograft vasculopathy. Circulation 2004;110:1650-1657.

224. Katsuragi N, Morishita R, Nakamura N, Ochiai T, Taniayama Y, Hasegawa Y, Kawashima K, Kaneda Y, Ogihara T, Sugimura K. Periostin as a novel factor responsible for ventricular dilation. Circulation 2004;110:1806-1813

225. Shimamura M, Sato N, Taniyama Y, Yamamoto S, Endoh M, Kurinami H, Aoki M, Ogihara T, Kaneda Y, Morishita R. Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound. Gene Therapy 2004;11:1532-1539

226. Hiraoka K, Yamamoto S, Otsuru S, Nakai S, Tamai K, Morishita R, Ogihara T, Kaneda Y. Enhanced tumor-specific long-term immunity of Hemagglutinating Virus of Japan-mediated dendritic cell-tumor fused cell vaccination by coadministration with CpG oligodeoxynucleotides. Journal of Immunology 2004;173:4297-4307.

227. Yamasaki K, Aoki M, Makino H, Hashiya N, Shimizu H, Ohishi M, Ogihara T, Morishita R. Effect of nifedipine on endothelial function in normotensive smokers: potential contribution of increase in circulating hepatocyte growth factor. Journal of Human Hypertension 2004;28:701-705

228. Powell RJ, Dormandy J, Simons M, Morishita R, Annex BH. Therapeutic angiogenesis for critical LIMB ischemia: design of the haptocyte growth factor therapeutic angiogenesis clinical trial. Vascular Medicine 2004;9:1-6

229. Tomita N, Kim JY, Gibbons GH, Zhang L, Kaneda Y, Stahl RA, Ogborn M, Venderville B, Morishita R, Baran D, Dzau VJ. Gene therapy with an E2F transcription factor decoy inhibits cell cycle progression in rat anti-Thy 1 glomerulonephritis. Int J Mol Med. 2004;13:629-636

230. Ahn JD, Morishita R, Kaneda Y, Kim HJ, Kim YD, Lee HJ, Lee KU, Park JY, Kim YH, Park KK, Chang YC, Yoon KH, Kwon HS, Park KG, Lee IK. Transcription factor decoy for AP-1 reduces mesangial cell proliferation and extracellular matrix production in vitro and in vivo. Gene Ther. 2004;11:916-923.

231. Koike H, Tomita N, Azuma H, Taniyama Y, Yamasaki K, Kunugiza Y, Tachibana K, Ogihara T, Morishita R. An efficient gene transfer method mediated by ultrasound and microbubbles into the kidney. Journal of Gene Medicine 2005;7:108-116.

232. Kato N, Nemoto K, Nakanishi K, Morishita R, Kaneda Y, Uenoyama M, Ikeda T, Fujikawa K. Nonviral gene transfer of human hepatocyte growth factor improves streptozotocin-induced diabetic neuropathy in rats. Diabetes. 2005;54:846-854.

233. Miwa K, Nakashima H, Aoki M, Miyake T, Kawasaki T, Iwai M, Oishi M, Kataoka K, Ohigi S, Ogihara T, Kaneda Y, Morishita R. Inhibition of ets, an essential transcription factor for angiogenesis, to prevent the development of abdominal aortic aneurysm in a rat model. Gene Therapy 2005;12:1109-1118.

234. Makino H, Aoki M, Hashiya N, Yamasaki K, Shimizu H, Ogihara T, Morishita R. A calcium channel blocker, benidipine, improves forearm reactive hyperemia in patients with essential hypertension. Blood Pressure Suppl. 2005;1:39-44.

235. Yumoto A, Fukushima Kusano K, Nakamura K, Hashimoto K, Aoki M, Morishita R, Kaneda Y, Ohe T. Hepatocyte growth factor gene therapy reduces ventricular arrhythmia in animal models of myocardial ischemia. Acta Med Okayama. 2005;59:73-78.

236. Kato N, Nemoto K, Nakanishi K, Morishita R, Kaneda Y, Uenoyama M, Ikeda T, Fujikawa K. Nonviral HVJ (hemagglutinating virus of Japan) liposome-mediated retrograde gene transfer of human hepatocyte growth factor into rat nervous system promotes functional and histological recovery of the crushed nerve. Neurosci Res. 2005;52:299-310.

237. Tashiro H, Aoki M, Isobe M, Hashiya N, Makino H, Kaneda Y, Ogihara T, Morishita R. Development of novel method of non-viral efficient fene transfer into neonatal cardiac myocytes. Journal of Molecular and Cellular Cardiology 2005;39:503-509

238. Morishita N, Nakagami H, Morishita R, Takeda S, Mishima F, Tarazono B, Nishijima S, Kaneda Y, Tanaka N. Magnetic nanoparticles with surface modification enhanced gene delivery of HVJ-E vector. Biochemical Biophysical Research Communications 2005;334:1121-1126.

239. Taniyama Y, Kurinami H, Tanaka H, Takami T, Ogihara T, Tohyama M, Kaneda Y, Morishita R. Gene transfer into adult rat spinal cord using naked plasmid DNA and ultrasound microbubbles. Journal of Gene Medicine 2005;7:1468-1474

240. Nakagami H, Maeda K, Morishita R, Iguchi S, Nishikawa T, Takami Y, Kikuchi Y, Saito Y,. Tamai K, Ogihara T, Kaneda Y. Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells. Artrioscleros, Thrombosis and Vascular Biology 2005;25:2542-2547.

241. Inagaki H, Suzuki J, Ogawa M, Taniyama Y, Morishita R, Isobe M. Ultrasound-microbubble mediated NF-kB decoy transfection attenuates neointimal formation after arterial injury in mice. Journal of Vascular Research 2006;43:12-18

242. Kim YD, Park KG, Morishita R, Kaneda Y, Kim SY, Song DK, Kim HS, Nam CW, Lee HC, Lee KU, Park JY, Kim BW, Kim JG, Lee IK. Liver-directed gene therapy of diabetic rats using an HVJ-E vector containing EBV plasmids expressing insulin and GLUT 2 transporter. Gene Therapy 2006;13:216-224.

243. Miyake T, Aoki M, Shiraya S, Kawasaki T, Oishi M, Kataoka K, Tanemoto K, Ogihara T, Kaneda Y, Morishita R. Prevention of aneurysms by simultaneous inhibition of NF?B and ets using chimeric decoy oligonucleotides in rabbit model. Gene Therapy 2006;13:695-704

244. Shimamura M, Sato N, Waguri S, Uchiyama Y, Hayashi T, Iida H, Nakamura T, Ogihara T, Kaneda Y, Morishita R. Gene transfer of HGF gene improves learning and memory in the chronic stage of cerebral infarction. Hypertension 2006;47:742-751

245. Koibuchi N, Taniyama Y, Nagao K, Ogihara T, Kaneda Y, Morishita R. The Effect of VEGF on blood vessels and blood cells during Xenopus development. Biochemical Biophysical Research Communications 2006;344:339-345

246. Shimizu H, Nakagami H, Tsukamoto I, Morita S, Kunugiza Y, Tomita T, Yoshikawa H, Kaneda Y, Ogihara T, Morishita R. NFkB decoy oligodeoxynucleotides ameliorates osteoporosis through inhibition of activation and differentiation of osteoclasts. Gene Therapy 2006;13:933-941

247. Nishikawa T, Nakagami H, Matsuki A, Maeda A, Yo CY, Harada T, Morishita R, Tamai K, Kaneda Y. Development of high throughput functional screening of therapeutic genes using HVJ-E vector. Human Gene Therapy 2006;17:470-475

248. Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura H, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaki M, Takeda M, Ogihara T, Morishita R. for Alzheimer Diseasesoluble A?42 is more resistant to dissociate from fibrils. Neurobiology of Disease 2006;22:487-495.

249. Nakagami H, Nakagawa N, Takeya Y, Kashiwagi K, Ishida C, Hayashi S, Aoki M, Matsumoto K, Nakamura T, Ogihara T, Morishita R. A model of vasculogenesis from ES cells for vascular research and regenerative medicine. Hypertension 2006;48:112-119

250. Kunugiza Y, Tomita N, Taniyama Y, Tomita T, Osako MK, Tamai K, Tanabe T, Kaneda Y, Yoshikawa H, Morishita R. Acceleration of wound healing by combined gene transfer of hepatocyte growth factor and prostacycline synthase with shima jet. Gene Therapy 2006;13:1143-1152

251. Tomita T, Kunugiza Y, Tomita N, Takano H, Morishita R, Kaneda Y, Yoshikawa H. E2F decoy oligodeoxynucleotide ameliorates cartilage invasion by infiltrating synovium derived from rheumatoid arthritis. International Journal of Molecular Medicine 2006;18:257-265

252. Azuma H, Taniyama Y, Takeya Y, Iekushi K, Aoki M, Dosaka N, Matsumoto K, Nakamura T, Ogihara T, Morishita R. Angiogenic and anti-fibrotic actions of hepatocyte growth factor improve cardiac dysfunction in porcine ischemic cardiomyopathy. Gene Therapy 2006;13:1206-1213.

253. Saito Y, Nakagami H, Morishita R, Takami Y, Kikuchi Y, Hayashi H, Nishikawa T, Tamai K, Azuma N, Sasajima T, Kaneda Y. Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesis. Circulation 2006;114:1177-1184

254. Miyake T, Aoki M, Shiraya S, Tanemoto K, Ogihara T, Kaneda Y, Morishita R. Inhibitory effects of NF?B decoy oligodeoxynucleotides on neointimal hyperplasia in a rabbit vein graft model. Journal of Molecular and Cellular Cardiology 2006;41:431-440

255. Shiraya S, Miwa K, Aoki M, Miyake T, Oishi M, Kataoka K, Ohgi S, Ogihara T, Kaneda Y, Morishita R. Hypertension accelerated experimental abdominal aortic aneurysm through up-regulation of transcription factors, NF?B and Ets. Hypertension 2006;48:628-636

256. Koike H, Ishida A, Shimamura M, Mizuno S, Nakamura T, Ogihara T, Kaneda Y, Morishita R. Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson�s disease. Gene Therapy 2006;13:1639-1644

257. Ohtani K, Egashira K, Nakano K, Zhao G, Funakoshi K, Ihara Y, Kimura S, Tominaga R, Morishita R, Sunagawa K. Stent-based local delivery of nuclear factor-kB decoy attenuates in-stent restenosis in hypercholesterolemic rabbits. Circulation 2006;114:2773-2779

258. Kunugiza Y, Tomita T, Tomita N, Morishita R, Yoshikawa H. Inhibitory effect of ribbon-type NF-kappaB decoy oligodeoxynucleotides on osteoclast induction and activity in vitro and in vivo. Arthritis Research & Therapy. 2006;8:R103

259. Tomita N, Yamasaki K, Izawa K, Kunugiza Y, Osako MK, Ogihara T, Morishita R. Improvement of organ damage by a non-depressor dose of imidapril in diabetic spontaneously hypertensive rats. International Journal of Molecular Medicine. 2007;19:571-579

260. Wakayama K, Shimamura M, Sata M, Sato N, Kawakami K, Fukuda H, Tomimatsu T, Ogihara T, Morishita R. Quantitative measurement of neurological deficit after mild (30 min) transient middle cerebral artery occlusion in rats. Brain Research Brain Research 2007;1130:181-187.

261. Shimamura M, Sato N, Sata M, Wakayama K, Ogihara T, Morishita R. Expression of hepatocyte growth factor and c-met after spinal cord injury in rats. Brain Research 2007;1151:188-194

262. Iekushi K, Taniyama Y, Azuma J, Katsuragi N, Dosaka N, Sanada F, Koibuchi N, Nagao K, Ogihara T, Morishita R. Novel mechanisms of the beneficial effect of an angiotensin receptor blocker, valsartan, on the treatment of heart failure through the inhibition of anti-adhesion molecule, periostin. Hypertension 2007;49:1409-1414

263. Osako MK, Tomita N, Nakagami H, Kunugiza Y, Yoshino M, Yuyama K, Tomita T, Yoshikawa H, Ogihara T, Morishita R. Increase in nuclease resistance and incorporation of -do by modification of 3�-terminus. Journal of Gene Medicine 2007;9:812-819.

264. Taniguchi H, Fujiwara Y, Doki Y, Sugita Y, Souma I, Miyata H, Takiguchi S, Yasuda T, Tomita N, Morishita R, Monden M. Gene therapy using ets-1 transcription factor decoy for peritoneal dissemination of gastric cancer. International Journal of Cancer 2007;121:1609-1617

265. Takami Y, Nakagami H, Morishita R, Katsuya T, Cui TX, Ichikawa T, Saito Y, Hayash H, Kikuchi Y, Nishikawa T, Baba Y, Yasuda O, Rakugi H, Ogihara T, Kaneda Y. Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-?B activation. Arteriosclerosis, Thrombosis, & Vascular Biology 2007;27:2184-2190

266. Shimizu N, Azuma N, Nishikawa T, Hirata S, Morishita R, Kaneda Y, Sasajima T. Effect on vein graft intimal hyperplasia of nuclear factor-kB decoy transfection using the second generation of HVJ vector. Journal of Cardiovascular Surgery (Torino). 2007;48:463-470.

267. Hayashi H, Nakagami H, Takami Y, Sato N, Saito Y, Nishikawa T, Mori M, Koriyama H, Tamai K, Morishita R, Kaneda Y. Involvement of gamma-secretase in postnatal angiogenesis. Biochemical Biophysical Research Communications 2007;363:584-590

268. Shimamura M, Sato N, Sata M, Kurinami H, Takeuchi D, Wakayama K, Kawakami K, Hayashi T, Iida H, Morishita R. Delayed post-ischemic treatment with fluvastatin improved learning and memory deficit after stroke in rats. Stroke 2007;38:3251-3258

269. Nakagawa A, Aoki M, Miyake T, Shiraya S, Nakamura T, Ogihara T, KImata Y, Morishita R. Improvement of survival of skin flaps by combined gene transfer of hepatocyte growth factor and prostacycline synthase, Journal of Gene Medicine 2007;9:1087-1094

270. Miyake T, Aoki M, Masaki H, Kawasaki T, Oishi M, Kataoka K, Ogihara T, Kaneda Y, Morishita R. Regression of abdominal aortic aneurysms by simultaneous inhibition of NF?B and ets in a rabbit model. Circulation Research 2007;101:1175-1184

271. Aoki T, Kataoka H, Shimamura M, Nakagami H, Wakayama K, Moriwaki T, Ishibashi R, Nozaki K, Morishita R, Hashimoto N. NF-?B is a key mediator of cerebral aneurysm formation. Circulation 2007;116:2830-2840.

272. Nagao K, Taniyama Y, Koibuchi N, Morishita R. Constitutive over-expression of VEGF results in reduced expression of Hand-1 during cardiac development in Xenopus. Biochemical Biophysical Research Communications 2007;359:431-437.

273. Nakagami H, Kikuchi Y, Katsuya T, Morishita R, Akasaka H, Saitoh S, Rakugi H, Kaneda Y, Shimamoto K, Ogihara T. Gene polymorphism of myospryn (cardiomyopathy-associated 5) is associated with left ventricular wall thickness in patients with hypertension. Hypertension Research 2007;30:1239-1246.

274. Azuma H, Tomita N, Sakamoto T, Kiyama S, Inamoto T, Takahara K, Kotake Y, Segawa N, Morishita R, Takahara S, Hayasaki H, Otsuki Y, Horie S, Tanigawa N, Katsuoka Y. Marked regression of liver metastasis Marked regression of liver metastasis by combined therapy of ultrasound-mediated NFkB-decoy transfer and transportal injection of paclitaxel, in mouse Int J Cancer. 2008;122:1645-1656.

275. Tomita N, Yamasaki K, Izawa K, Kunugiza Y, Osako MK, Ogihara T, Morishita R. Inhibition of experimental abdominal aortic aneurysm progression by nifedipine. International Journal of Molecular Medicine 2008;21:239-244.

276. Takeuchi D, Sato N, Shimamura M, Kurinami H, Takeda S, Shinohara M, Suzuki S, Kojima M, Ogihara T, Morishita R. Alleviation of A?-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in mouse model. Gene Therapy 2008;15:561-571

277. Kurinami H, Sato N, Shinohara M, Takeda S, Takeuchi D, Shimamura M, Ogihara T, Morishita R. Prevention of A?-induced memory impairment by fluvastatin through the loss of neuron decrease in A? accumulation and oxidative stress. International Journal of Molecular Medicine 2008;21:531-537.

278. Nagao K, Taniyama Y, Kietzmann T, Doi T, Komuro I, Morishita R. HIF-1? signaling upstream of Nkx2.5 is required for development of heart morphology in Xenopus. Journal of Biological Chemistry 2008;283:11841-11849

279. Saito Y, Nakagami H, Kuraoka M, Takami Y, Kikuchi Y, Hayashi H, Nishikawa T, Tamai K, Morishita R, Azuma N, Sasajima T, Kaneda Y. Cold shock domain protein A represses angiogenesis and lymphangiogenesis via inhibition of serum response element. Oncogene 2008;27:1821-1833

280. Egashira K, Suzuki J, Ito H, Aoki M, Isobe M, Morishita R. Long-term Follow Up of Initial Clinical Cases With NF-kB Decoy Oligodeoxynucleotide Transfection at the Site of the Coronary Stenting. Journal of Gene Medicine 2008;10:805-809.

281. Takeya Y, Makino H, Aoki, M, Miyake T, Ozaki K, Rakugi H, Ogihara T, Morishita R. In vivo evidence of enhancement of HGF-induced angiogenesis by fluvastatin. The Open Gene Therapy Journal 2008;1:1-6

282. Powell RJ, Simons M, Mendersohn F, Daniel G, Henry T, Koga M, Morishita R, Annex B. Results of a double-blind placebo-controlled study to assess the safety and efficacy of intramuscular injection of HGF plasmid to improve limb perfusion in patients with critical limb ischemia (HGF-STAT Trial). Circulation 2008;118:58-65

283. Shimizu H, Nakagami H, Osako MK, Hanayama R, Kunugiza Y, Kizawa T, Tomita T, Yoshikawa H, Ogihara T, Morishita R. Angiotensin IIcceraletesaos byango. The FASEB Journal 2008;22: 2465-2475

284. Nakagami H, Osako MK, Takami Y, Hanayama R, Koriyama H, Mori M, Hayashi H, Shimizu H, Morishita R. Differential response on vascular HGF concentration and lipid accumulation between telmisartan and losartan in ApoE-deficient mice. Molecular Medicine Reports 2008;1:657-661.

285. Miyake T, Aoki M, Morishita R. Inhibition of anastomotic intimal hyperplasia using a chimeric decoy strategy against NFkB and E2F in a rabbit model. Cardiovascular Research 2008;79:706-714

286. Takami Y, Nakagami H, Morishita R, Katsuya T, Hayashi H, Mori M, Koriyama H, Baba Y, Yasuda O, Rakugi H, Ogihara T, Kaneda Y. Potential role of CYLD (cylindromatosis) as a deubiquitinating enzyme in vascular cells. American Journal of Pathology. 2008;172:818-829

287. Tsubouchi M, Morishita R, Tabata Y, Matsui S, Kawakami K. Critical issues for effective corroboration between academia and industry in the field of regenerative medicine in Japan. Regenerative Medicine 2008;3:497-504

288. Wakayama K, Shimamura M, Sata M, Koibuchi N, Sato N, Morishita R. A novel model of cerebrovascularinjury in rats. Journal of Neuroscience Methods 2008;175:187-195

289. Fujiwara Y, Shiraya S, Miyake T, Yamanaka S, Aoki M, Makino H, Nishimura M, Morishita R. Inhibition of development of experimental aortic abdominal aneurysm in a rat model by the angiotensin II receptor blocker valsaratan. International Journal of Molecular Medicine 2008;22:703-708

290. Sanada F, Taniyama Y, Azuma J, Iekushi K, Dosaka N, Yokoi T, Oshita Y, Koibuchi N, Aizawa Y, Morishita R. Hepatocyte growth factor, but not vascular endothelial growth factor, attenuated angiotensin II-induced senescence and oxidative stress in monocytic endothelial progenitor cells by inhibiting PIP3 activity. Hypertension 2008;53:77-82

291. Tsuchihara T, Ogata S, Nemoto K, Okabayashi T, Nakanishi K, Kato N, Morishita R, Kaneda Y, Uenoyama M, Suzuki S, Amako M, Kawai T, Arino H. Nonviral retrograde gene transfer of human hepatocyte growth factor improves neuropathic pain-related phenomena in rats. Molecular Therapy. 2009;17:42-50

292. Suzuki J, Tezuka D, Morishita R, Isobe M. An Initial Case of Suppressed Restenosis with NF-?B Decoy Transfection After PCI. Journal of Gene Medicine 2009;11:89-91.

293. Shiraya S, Aoki M, Miyake T, Ohgi S, Nishimura S, Ogihara T, Morishita R. Inhibition of development of experimental aortic abdominal aneurysm in rat model by atorvastatin through the inhibition of macrophage migration. Atherosclerosis 2009;202:34-40

294. Tsukada Y, Hara K, Bando Y, Huang CC, Kousaka Y, Kawashima Y, Morishita R, Tsujimoto H. Particle size of control of poly(DL-lactide-co-glycodite) nanospheres for sterile application. International Journal of Pharmaceutics 2009;307:196-201.

295. Hanayama R, Shimizu H, Nakagami H, Osako MK, Makino H, Kunugiza Y, Tomita T, Tsukamoto I, Yoshikawa H, Rakugi H, Morishita R. Fluvastatin improves osteoporosis in fructose-fed insulin resistant model rats through blockade of the classical mevalonate pathway and antioxidant action. International Journal of Molecular Medicine 2009;23:581-588.

296. Nakagami H, Osako MK, Hanayama R, Koriyama H, Shimizu H, Morishita R. Vascular protective effects of ezetimibe in apoE-deficient mice. Atherosclerosis 2009;203:51-58

297. Aoki T, Kataoka H, Ishibashi R, Nakagami H, Nozaki K, Morishita R, Hashimoto N. Pitavastatin suppresses formation and progression of cerebral aneurysms through inhibition of the nuclear factor kappaB pathway. Neurosurgery. 2009;64:357-365.

298. Kimura S, Egashira K, Chen L, Nakano K, Iwata E, Miyagawa M, Tsujimoto J, Hara K, Morishita R, Sueishi K, Tominaga R, Sunagawa K. Nanoparticle-mediated delivery of nuclear factor kB decoy into lungs ameliorates monocrotaline-induced pulmonary arterial hypertension. Hypertension 2009;53:877-883,

299. Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R. Elevation of Plasma ?-amyloid Level by Glucose Loading in Alzheimer Mouse Models. Biochemical and Biophysical Research Communications 2009;385:193-197

300. Takeda S, Sato N, Niisato K, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Kano M, Morishita R. Validation of A?1-40 administration into mouse cerebroventricles as an animal model for alzheimer disease. Brain Research 2009;1280:137-147.

301. Mori M, Nakagami H, Koibuchi N, Miura K, Takami Y, Koriyama H, Hayashi H, Sabe H, Mochizuki N, Morishita R, Kaneda Y. Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis. Molecular Biology & Cell. 2009;20:3115-3124.

302. Hayashi H, Nakagami H, Takami Y, Koriyama H, Mori M, Tamai K, Sun J, Nagao K, Morishita R, Kaneda Y. FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1. Arteriosclerosis, Thrombosis, & Vascular Biology 2009;29:909-914

303. Aoki T, Kataoka H, Ishibashi R, Nozaki K, Morishita R, Hashimoto N Reduced collagen biosynthesis is the hallmark of cerebral aneurysm. contribution of interleukin-1b and Nuclear Factor-kB. Arteriosclerosis, Thrombosis, & Vascular Biology 2009;29:1080-1086.

304. Morishita R, Ishii J, Kasumi Y, Yamada S, Komai N, Ohishi M, Nomura M, Hishida H, Niihashi M, Mitsumata M. Association of serum oxidized lipoprotein(a) concentration with coronary artery disease: Potential role of oxidized Lipoprotein(a) in the vascular wall. Journal of Atherosclerosis and Thrombosis 2009;410-418

305. Shimizu H, Nakagami H, Osako MK, Nakagami F, Kunugiza Y, Tomita T, Yoshikawa H, Rakugi H, Ogihara T, Morishita R. Prevention of Osteoporosis by Angiotensin Converting Enzyme Inhibitor in Spontaneous Hypertensive Rats. Hypertension Research 2009;32:786-790

306. Hayashi S, Sato N, Yamamoto A, Ikegami Y, Nakajima S, Morishita R. Alzheimer disease associated peptide, amyloid ?40 inhibits vascular regeneration with induction of endothelial autopsy. Arteriosclerosis, Thrombosis, & Vascular Biology 2009:29:1909-1915

307. Kim MS, Kim MS, Lee CS, Hur J, Cho HJ, Jun SI, Kim TY, Lee SW, Suh JW, Park KW, Lee HY, Kang HJ, Lee DS, Koh GY, Nakagami H, Morishita R, Park YB, Kim HS. Priming with angiopoietin-1 augments the vasculogenic potential of the peripheral blood stem cells mobilized with granulocyte colony-stimulating factor through a novel tie2/ets-1 pathway. Circulation 2009;120:2240-2250

308. Sanada F, Taniyama Y, Iekushi K, Azuma J, Dosaka N, Shimizu K, Kusunoki H, Koibuchi N, Aizawa Y, Morishita R. Negative action of HGF /c-Met system on angiotensin II signaling via ligand-dependent EGF receptor degradation mechanism in VSMC. Circulation Research 2009;105:667-675

309. Takeda S, Sato N, Takeuchi D, Kurinami H, Shinohara M, Niisato K, Kano M, Ogihara T, Rakugi H, Morishita R. Angiotensin receptor blocker prevented �-Amyloid-induced cognitive impairment associated with recovery of neurovascular coupling. Hypertension 2009;54:1345-1352.

310. Aoki T, Nishimura M, Kataoka H, Ishibashi R, Miyake T, Takagi Y, Morishita R, Hashimoto N. Role of angiotensin II type 1 receptor in cerebral aneurysm formation in rats. International Journal of Molecular Medicine 2009;24:353-359

311. Shimizu H, Nakagami H, Morita S, Tsukamoto I, Osako MK, Nakagami F, Shimosato T, Minobe N, Morishita R. New treatment of periodontal diseases using NFkB decoy oligodeoxunuclotides via prevention of bone resorption and promotion of wound healing. Antioxidant & Redox Signal. 2009;11:2065-2075

312. Tomita N, Yamasaki K, Osako MK, Komai N, Shimosato T, Morishita R. Combination therapy based on angiotensin receptor blocker, olmesartan, for vascular protection in SHR. Molecular Medicine Reports 2009;2:733-738.

313. Nishikawa T, Nakagami H, Maeda A, Morishita R, Miyazaki N, Ogawa T, Tabata Y, Kikuchi Y, Hayashi H, Tatsu Y, Yumoto N, Tamai K, Tomono K, Kaneda Y. Development of novel antimicrobial peptide, AG-30, with angiogenic property. Journal of Cellular and Molecular Medicine 2009;13:535-546

314. Suzuki J, Ogawa M, Takayama K, Taniyama Y, Morishita R, Hirata Y, Nagai R, Isobe M. Ultrasound-microbubble mediated ICAM-1 siRNA transfection attenuates neointimal formation after arterial injury in mice. Journal of American College of Cardiology 2010;55:904-913.

315. Koriyama H, Nakagami H, Katsuya T, Akasaka H, Saitoh S, Shimamoto K, Ogihara T, Kaneda Y, Morishita R, Rakugi H. Variation in OSBPL10 is associated with dyslipidemia. Hypertension Research 2010;33:511-514.

316. Takeda S, Sato N, Ushio-Yamada K, Sawada K, Kunieda T, Kurinami H, Shinohara M, Fujisawa T, Rakugi H, Morishita R. Diabetes accelerated memory dysfunction via cerebrovascular inflammation and A� deposition in Alzheimer mouse model with diabetes. Proceeding of National Academy of Sciences USA 2010;107:7036-7041.

317. Oshima S, Fujimoto S, Petrov A, Nakagami H, Haider N, Zhou J, Tahata N, Osako MK, Fujimoto A, Zhu J, Edwards DS, Narula N, Wong N, Chandrashekhar Y, Morishita R, Narula J. Effect of an antimicrobial agent on atherosclerotic plaque and metalloproteinase production: assessment by molecular imaging. Journal of American Colledge of Cardiology 2010;55:1240-1249.

318. Shinohara M, Sato N, Kurinami H, Takeuchi D, Takeda S, Shimamura M, Yamashita T, Uchiyama Y, Rakugi H, Morishita R. Reduction of brain Abeta by fluvastatin, an HMG-CoA reductase inhibitor, through increase in degradation of APP-CTFs and Abeta clearance. Journal of Biological Chemistry. 2010;285:22091-22102

319. Morimoto D, Tomita T, Kuroda S, Higuchi C, Kato S, Shiba T, Nakagami H, Morishita R, Yoshikawa H. Inorganic polyphosphate differentiates human mesenchymal stem cells into osteoblastic cells. Journal of Bone Mineral Metabolism. 2010;28:418-423

320. Nakagami F, Nakagami H, Osako MK, Iwabayashi M, Taniyama Y, Shimizu H, Rakugi H, Morishita R. Estrogen attenuates vascular remodeling in Lp(a) transgenic mice. Atherosclerosis 2010;211:41-47

321. Osako MK, Nakagami H, Koibuchi N, Shimizu H, Nakagami F, Koriyama H, Katsuya T, Rakugi H, Morishita R. Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification. Circulation Research 2010;107:466-475

322. Shigematsu H, Yasuda K, Iwai T, Sasajima T, Ishimaru S, Ohashi Y, Yamaguchi T, Ogihara T, Morishita R. Randomized, double-blind, placebo-controlled clinical trial of hepatocyte growth factor plasmid for critical limb ischemia. Gene Therapy. 2010;17:1152-1161

323. Aoki T, Kataoka H, Nishimura M, Ishibashi R, Morishita R, Miyamoto S. Ets-1 promotes the progression of cerebral aneurysm by inducing the expression of MCP-1 in vascular smooth muscle cells. Gene Therapy 2010;17:1117-1123

324. Iekushi K, Taniyama Y, Azuma J, Sanada F, Yokoi T, Koibuchi N, Kusunoki H, Okayama K, Rakugi H, Morishita R. Hepatocyte growth factor attenuates angiotensin II induced renal fibrosis through TGF-?1 suppression by anoikis of myofibroblasts. Journal of Hypertension 2010;28:2454-2461.

325. Koriyama H, Nakagami H, Katsuya T, Sugimoto K, Yamashita H, Takami Y, Maeda S, Kubo M, Takahashi A, Nakamura Y, Ogihara T, Rakugi H, Kaneda Y, Morishita R. Identification of suggestive evidence of association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population. Journal of Atherosclerosis and Thrombosis 2010;17:1054-1062.

326. Sugimoto K, Katsuya T, Kamide K, Fujisawa T, Shimaoka I, Ohishi M, Morishita R, Ogihara T, Rakugi H. Promoter polymorphism of RGS2 gene is associated with change of blood pressure in subjects with antihypertensive treatment: the Azelnidipine and Temocapril in hypertensive patients with Type 2 diabetes STudy (ATTEST). International Journal of Hypertension 2010:196307

327. Shimizu H, Nakagami H, Yasumasa N, Osako MK, Shimamura M, Miyake T, Nakagami F, Koriyama H, Rakugi H, Morishita R. Combination of thiazide diuretics and angiotensin receptor blockers synergistically attenuates osteoporosis in hypertensive rats. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 2010;10:115-122.

328. Nakagami H, Osako MK, Nakagami F, Shimosato T, Minobe N, Moritani T, Shimamura M, Miyake T, Shimizu H, Takeya Y, Morishita R. Prevention and regression of non-alcoholic steatohepatitis (NASH) in a rat model by metabosartan, telmisartan. International Journal of Molecular Medicine. 2010;26:477-481.

329. Tahara K, Samura S, Tsuji K, Yamamoto H, Tsukada Y, Bando Y, Tsujimoto H, Morishita R, Kawashima Y. Oral nuclear factor-kB decoy oligonucleotides delivery system with chitosan modified poly(D,L-lactide-co-glycolide) nanospheres for inflammatory bowel disease. Biomaterials 2011;32:870-878

330. Miyake T, Aoki M, Osako MK, Shimamura M, Nakagami H, Morishita R. Development of ribbon-type decoy oligodeoxynucleotides (ODN): systemic administration of ribbon-type decoy ODN against NF?B and Ets binding sites prevented abdominal aortic aneurysm in rat model. Molecular Therapy 2011;19:181-187

331. Ohno K, Amano Y, Kakuta H, Niimi T, Takakura S, Orita M, Miyata K, Sakashita H, Takeuchi M, Komuro I, Higaki J, Horiuchi M, Kim-Mitsuyama S, Mori Y, Morishita R, Yamagishi S. Unique �Delta Lock� Structure of Telmisartan is Involved in its Strongest Binding Affinity to Angiotensin II Type 1 Receptor. Biochemical and Biophysical Research Communications 2011;404:434-437

332. Shioyama W, Nakaoka Y, Higuchi K, Minami Takashi, Taniyama Yoshiaki, Nishida Keigo, Kidoya H, Sonobe T, Naito H, Arita Y, Hashimoto T, Kuroda T, Fujio Y, Shirai M, Takakura N, Morishita R, Yamauchi-Takihara K, Kodama T, Hirano T, Mochizuki N, Komuro I. Docking Protein Gab1 is an Essential Component of Postnatal Angiogenesis After Ischemia via HGF/c-Met Signaling. Circulation Research. 2011;108:664-675

333. Morishita R, Makino H, Aoki M, Hashiya N, Yamasaki K, Azuma J, Taniyama Y, Sawa Y, Kaneda Y, Ogihara T. Phase I/IIa Clinical Trial of Therapeutic Angiogenesis Using Hepatocyte Growth Factor Gene Transfer to Treat Critical Limb Ischemia. Arteriosclerosis, Thrombosis, & Vascular Biology. 2011;31:713-720

334. Shigematsu H, Yasuda K, Sasajima T, Takano T, Miyata T, Ohta T, Tanemoto K, Obitsu Y, Iwai T, Ozaki S, Ogihara T, Morishita R. Transfection of human HGF plasmid DNA improves limb salvage in Buerger's disease patients with critical limb ischemia. International Angiology. 2011;30:140-149.

335. Kyutoku M, Taniyama Y, Katsuragi N, Shimizu H, Kunugiza Y, Iekushi K, Koibuchi N, Sanada F, Oshita Y, Morishita R. Role of periostin in cancer progression and metastasis: Inhibition of breast cancer progression and metastasis by anti-periostin antibody in a murine model. International Journal of Molecular Medicine 2011;28:181-186

336. Takeda S, Sato N, Ikimura K, Nishio H, Rakugi H, Morishita R. Novel Microdialysis Method to Assess Neuropeptides and Large Molecules in Free-moving Mouse. Neuroscience 2011;186:110-119

337. Iekushi K, Taniyama Y, Azuma J, Sanada F, Kusunoki H, Okayama K, Koibuchi N, Iwabayashi M, Rakugi H, Morishita R. Hepatocyte Growth Factor Attenuates TGF-?- Angiotensin II Crosstalk Through the Inhibition of PTEN/Akt Pathway. Hypertension 2011;58:190-196

338. Shimamura M, Nakagami H, Shimosato T, Moritani T, Nakagami F, Osako MK, Miyake T, Koriyama H, Shimizu H, Morishita R. Improvement of Endothelial Dysfunction, Abnormal Lipid Profile, Proteinuria, and Liver Dysfunction by Irbesartan in Zucker Diabetic Fatty Rats Independent of Glucose and Insulin Levels. Experimental and Therapeutic Medicine 2011;2: 957-961

339. Saito Y, Nakagami H, Azuma N, Hirata S, Sanada F, Taniyama Y, Morishita R, Kaneda Y, Sasajima T. Critical Roles of Cold Shock Domain Protein A as an Endogenous Angiogenesis Inhibitor in Skeletal Muscle. Antioxidants & Redox Signaling 2011;15:2109-2020

340. Aoki T, Nishimura M, Matsuoka T, Yamamoto K, Furuyashiki T, Kataoka H, Kitaoka S, Ishibashi R, Ishibazawa A, Miyamoto S, Morishita R, Ando J, Hashimoto N, Nozaki K, Narumiya S. PGE2-EP2 signaling in endothelium is activated to hemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-?B. Short running title; PGE2- EP2 induces cerebral aneurysm via NF-?B. British Journal of Pharmacology 2011;163:1237-1249

341. Nakagami H, Nishikawa T, Tamura N, Maeda A, Hibino H, Mochizuki M, Shimosato T, Moriya T, Morishita R, Tamai K, Tomono K, Kaneda Y. Modification of a Novel Angiogenic Peptide, AG30, for the Development of Novel Therapeutic Agents. Journal of Cellular and Molecular Medicine 2011. doi: 10.1111/j.1582-4934

342. Nakagami H, Shimamura M, Miyake T, Shimosato T, Minobe N, Moritani T, Osako MK, Nakagami F, Koriyama H, Kyutoku M, Shimizu H, Katsuya T, Morishita R. Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis (NASH) model induced by an L-methionine- and choline-deficient (MCA) diet. Molecular Medicine Reports 2012;5:37-40

343. Shimizu H, Nakagami H, Yasumasa N, Osako MK, Kyutoku M, Koriyama H, Nakagami F, Shimamura M, Rakugi H, Morishita R. Cilnidipine, but not amlodipine, ameliorates osteoporosis in ovariectomized hypertensive rats through inhibition of N-type calcium channel. Hypertension Research 2012;35:77-81

344. Kusunoki H, Taniyama Y, Azuma J, Iekushi K, Sanada F, Otsu R, Iwabayashi M, Okayama K, Rakugi H, Morishita R. Telmisartan Exerts Renoprotective Actions via PPAR?/HGF Pathway Independent of Angiotensin II Type 1 Receptor Blockade. Hypertension 2012;59:308-316

345. Morishita R, Itakura H, Nakaya N, Yoshida M, Odawara M, Ichihara A, Muzuno K. Risk Factors on Cardiovascular Events in the Japanese Patients Treated with Fluvastatin from LEM study. Current Vascular Phamacology 2012;10:178-186

346. Nakagami H, Osako MK, Yasumasa N, Shimamura M, Kyutoku M, Nakagami F, Koriyama H, Tomioka H, Katsuya T, Morishita R. Pitavastatin Improves Endothelial Function and Glucose Metabolism in Ovariectomized Mice. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 2012;12:29-33

347. Suzuki J, Tezuka D, Morishita R, Isobe M. Eight-Year Follow-Up of an Initial Case with NF-kB Decoy Oligodeoxynucleotide Transfection After Coronary Stent Implantation. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 2012;12:40-42.

348. Okayama K, Azuma J, Dosaka N, Iekushi K, Sanada F, Kusunoki H, Iwabayashi M, Rakugi H, Taniyama Y, Morishita R. Hepatocyte Growth Factor Reduces Cardiac Fibrosis by Inhibiting Endothelial-mesenchymal Transition. Hypertension. 2012;59:958-965.

349. Iwabayashi M, Taniyama Y, Sanada F, Azuma J, Iekushi K, Kusunoki H, Amarnath Chatterjee, Okayama K, Rakugi H, Morishita R. Role of Serotoin in Angiogenesis: Induction of Angiogenesis via Endothelial 5-HT1B/Akt/eNOS Pathway by Sarpogrelate in Diabetic Mice. Atherosclerosis 2012;220:337-342

350. Shimamura M, Taniyama Y, Katsuragi N, Koibuchi N, Kyutoku M, Sato N, Allahtavakoli M, Wakayama K, Nakagami H, Morishita R. Role of Central Nervous System Periostin in Cerebral Ischemia. Stroke 2012;43:1108-1114

351. Yokoi T, Azuma J, Nakade Y, Sanada F, Iekushi K, Yoshika M, Masuda M, Komiyama Y, Taniyama Y, Masaki H, Morishita R, Takahashi H. Comparison between Two Calcium Antagonists: Blood Pressure Reduction and Renal Effects in Hypertensive Patients with Type 2 Diabetes. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 2012;12:152-159

352. Kaga T, Kawano H, Sakaguchi M, Nakazawa T, Taniyama Y, Morishita R. HGF (Hepatocyte growth factor) stimulated angiogenesis without inflammation: Differential actions between HGF, VEGF (vascular endothelial growth factor) and bFGF (basic fibroblast growth factor). Vascular Pharmacology 2012;19:3-9

353. Shimizu H, Nakagami H, Yasumasa N, Osako MK, Kyutoku M, Koriyama H, Nakagami F, Shimamura M, Rakugi H, Morishita R. Screening of anti-hypertensive drugs on osteoclastic acid secretion and bone resorption by acridine orange. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry. 2012;12:161-167

354. Iwabayashi M, Taniyama Y, Sanada F, Azuma J, Iekushi K, Okayama K, Kusunoki H, Amarnath Chatterjee, Rakugi H, Morishita R. Inhibition of Lp(a)-induced Impairment on Angiogenesis of Endothelial Cells and Endothelial Progenitor Cells by Hepatocyte Growth Factor. Biochemical and Biophysical Research Communications 2012;423:79-84

355. Takeda S, Sato N, Yamada-Uchino K, Yu H, Moriguchi A, Rakugi H, Morishita R. Oral Glucose Loading Modulates Plasma A� Levels in Alzheimer Disease Patients: Potential Diagnosis Method of Alzheimer Disease. Dementia and Geriatric Cognitive Disorders 2012;34:25-30

356. Huang CY, Lin FY, Shih CM, Au HK, Chang YJ, Nakagami H, Morishita R, Chang NC, Shyu KG, Chen JW. Moderate to HIgh Concentrations of High Density Lipoprotein from Healthy Subjects Paradoxically Impair Human Endothelial Progenitor Cells and Related Angiogenesis by Activating Rho-associated Kinase Pathways. Arteriosclerosis, Thrombosis, & Vascular Biology 2012;32:2405-2417

357. Makino H, Aoki M, Hashiya N, Yamasaki K, Azuma J, Sawa Y, Kaneda Y, Ogihara T, Morishita R. Long Term Follow Up Evaluation of Results From Clinical Trial (TREAT-HGF) Using Hepatocyte Growth Factor Gene to Treat Severe Peripheral Arterial Disease. Arteriosclerosis, Thrombosis, & Vascular Biology 2012;32:2503-2509

358. Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Araujo RG, Maeda A, Morishita R, Tamai K, Kaneda Y. HIG1, a novel regulator of mitochondrial??-secretase, maintains normal mitochondrial function. FASEB Journal 2012;26:2306-2317

359. Aoki T, Kataoka H, Nishimura M, Ishibashi R, Morishita R, Miyamoto S. Regression of Intracranial Aneurysms by Simultaneous Inhibition of NF-?B and Ets with Chimeric Decoy Oligodeoxynucleotide Treatment. Neurosurgery. 2012;70:1534-1543

360. Chatterjee A, Kusunoki H, Taniyama Y, Rakugi H, Morishita R. Improvement of Metabolic Syndrome by Irbesartan via the PPAR?/HGF Pathway in Apolipoprotein E Knockout Mice. Biomedial Reports 2012;1:65-70

361. Shimizu K, Taniyama Y, Sanada F, Iekushi K, Kyutoku M, Okayama K, Kusunoki H, Iwabayashi M, Azuma J, Morishita R. Hepatocyte Growth Factor Inhibits LPS-induced Oxidative Stress via Epithelial Growth Factor Receptor Degradation. Arteriosclerosis, Thrombosis, & Vascular Biology 2012;32:2687-2693

362. Kikuchi Y, Nakagami H, Katsuya T, Morishita R, Horio T, Kamide K, Miyata T, Kawano Y, Takami Y, Rakugi H, Kaneda Y, Ogihara T. A gPolymorphism of the myospryn is associated with left ventricular diastolic dysfunction. Anti-aging Medicine (in press)

363. Shimizu H, Nakagami H, Yasumasa N, Osako MK, Kyutoku M, Koriyama H, Nakagami F, Shimamura M, Rakugi H, Morishita R. Links between Hypertension and Osteoporosis Benidipine ameliorates osteoporosis in ovariectomized hypertensive rats through promotion of osteoblast proliferation and inhibition of osteoclast differentiation. Current Cardiovascular Risk Reports (in press)

364. Huang CY, Shih CM, Tsao NW, Lin YW, Huang PH, Wu SC, Lee AW, Kao YT, Chang NC, Nakagami H, Morishita R, Ou KL, Hou WC, Lin CY, Shyu KG, Lin FY. Dipeptidyl peptidase-4 inhibitor improves neovascularization by increasing circulating endothelial progenitor cells. British Journal of Pharmacology (in press)

365. Ozaki K, Makino H, Miyake T, Yasumasa N, Osako MK, Nakagami H, Rakugi H, Morishita R. Therapeutic Effect of Ribbon Type NF-?B Decoy Oligonucleotides on Inflammatory Bowel Disease Model Rats. Current Gene Therapy (in press)

366. Sato N, Okochi M, Shinohara M, Thinakaran G, Takeda S, Fukumori A, Shinohara-Noma M, Mori-Ueda M, Hamada H, Takeda M, Rakugi H, Morishita R. Differential regulation of amyloid precursor protein /presenilin 1 interaction during A?40/42 production detected using fusion constructs. Plos ONE (in press)

367. Rodriguez-Araujo G, Nakagami H, Hayashi H, Mori M, Shiuchi T, Minokoshi Y, Nakaoka Y, Takami Y, Komuro I, Morishita R, Kaneda Y. Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway. Cellular and Molecular Life Sciences. (in press)

Scientific Activities

Professional activities & appointments

� Committee for Industry-Academia Relationship, Ministry of Education, Science and Culture of Japan

� Committee for Human Resource, Ministry of Education, Science and Culture of Japan

� Committee for Intellectual Property, Ministry of Economy, Trade and Industry

� Vice Chairman, Bio-Venture Association Originated from Universities

� Past Member of Headquarter for Intellectual Property Strategy, Cabinet Office (Koizumi & Abe Cabinet)

Professional Societies:

Board: Japan Society of Hypertension, Japan Society of Vascular Biology Organization, Society for Intellectual Property, Japan Society of Anti-Aging, Japan Society of Gene Therapy, Japan Society of Venture

Fellow: Council of Circulation, American Heart Association, Council of Atherosclerosis, American Heart Association, Council of High Blood Pressure, American Heart Association, American College of Angiology, Japanese Society of Nephrology, Japanese Society of Pharmacology, Japanese Society of Atherosclerosis, Japanese Society of Endocrinology, Japanese Society of Cardiovascular & Endocrinology, Council of Basic Science, American Heart Association, Japanese Society of Gerontology, Japanese Society of Molecular Medicine, The Japan Society of Inflammation and Regeneration, International Society of Heart Research

Member: International Society of Nephrology, American Society of Gene Therapy, North American Vascular Biology Organization, Japanese Society of Circulation, Japanese Society of Internal Medicine

Honors

Honors:

1991 Award in Japan Research Foundation for Clinical Pharmacology

1991-1992 Award in Japan Heart Foundation

1992-1994 Postdoctoral Fellowship Grant in American Heart Association, California

1993 Award in American Federation Clinical Research

1993 Upjohn Young Investigator Award in Cardiology, Stanford University

1994 Young Investigator Award of the Dr. C & F. Demuth Medical Foundation at the 15th Scientific

Meeting of the International Society of hypertension in Melbourne, Australia.

1994 Award in American Federation Clinical Research

1994 Award in Second Conference "Hypertension and Vascular Metabolisms"

1994 Young Investigator Award in Japan Vascular Disease Research Foundation

1996 Young Investigator Award (First winner) in Japanese Circulation Society

1996 Young Investigator Award in Japanese Atherosclerosis Society

1996 Harry Goldbratt Award in Council of High Blood Pressure, American Heart Association

1997 Young Investigator Award in 11th International Symposium on Atherosclerosis

1997 Young Investigator Award in 1st annual meeting of the Society of Cardiovascular &

Endocrinology

1998 Young Investigator Award in 71th annual meeting of the Society of Endocrinology

1999 Young Investigator Award in the annual meeting of the Society of Pharmacology

1999 Award in Japanese of Japan Medical Society

2001 Takamine Jokichi Award in 5th annual meeting of the Society of Cardiovascular &

Endocrinology

2001 Young Investigator Award in 2nd annual meeting of the Japanese Society of Hypertension

2002 Sato Award in 27th annual meeting of the Japanese Circulation Society

2003 Japan Innovator Award in 1st meeting (Nikkei BP)

2003 Award from Minister of Education in 1st meeting

2005 Invitrogen-Nature-Biotechnology Award

2011 Japan Venture Awards 2011


Kesheng WangPhD

Assistant Professor
Department of Biostatistics and Epidemiology
College of Public Health East Tennessee State Univ
Address:USA
Biography

Kesheng Wang received his PhD in Genetics (Population Genetics) and Biometry from the University of Goettingen, Germany. Currently, he is working as an Assistant Professor at the Department of Biostatistics and Epidemiology, East Tennessee State University. His research interests focus on Biostatistics, Chronic Disease Epidemiology, and Genetic Epidemiology/Statistical Genetics.

Research Interests

Application of multiple linear and logistic regression models, applied longitudinal data analysis, generalized linear and non-linear mixed models, and survival analysis; epidemiology of chronic diseases including alcohol use disorders and drug abuse, cancer, obesity and diabetes, heart disease and stroke; genetic epidemiology of complex diseases including alcohol dependence and comorbidity, cancer, diabetes and related conditions.

Publications

Selected Publications in Peer-Reviewed Journals (2009-present)

1. Wang KS*. Relationship between attention deficit hyperactivity disorder and alcohol dependence: a genetic view. International Journal of High Risk Behaviors and Addiction. 2013; 1(4):192-193.

2. Wang KS*, Liu X. Integrative analysis of genome-wide expression and methylation data. Journal of Biometrics & Biostatistics. 2013; 4(1): e123.

3. Aragam NR, Wang KS*, Anderson JL, Liu X. TMPRSS9 and GRIN2B are associated with neuroticism: a genome-wide association study in a European sample. Journal of Molecular Neuroscience 2013;50(2):250-6.

4. Pan Y, Wang KS*, Wang L, Wu LY. Common variants in HLA-DRA gene are associated with alcohol dependence in two Caucasian samples. Journal of Molecular Neuroscience. 2013; 49(3): 574-581.

5. Xu C, Aragam N, Li X, Villla EC, Wang L, Posada Y, Arana TB, Cruz G, Mao CX, Escamilla MA, Wang KS*. BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies. PLoS ONE. 2013; 8(1): e51674.

6. Xu C, Mullersman J, Wang L, Su B, Mao CX, Posada Y, Camarillo C, Mao Y, Escamilla MA, Wang KS*. Polymorphisms in seizure 6-like (SEZ6L) gene are associated with bipolar disorder I: evidence of gene - gender interaction. Journal of Affective Disorder. 2013; 145(1): 95-99.

7. Xu C, Warsh JJ, Wang KS, Mao CX, Kennedy JL. Association of the iPLA2� gene with bipolar disorder and assessment of its interaction with TRPM2 gene polymorphisms. Psychiatry Genetics. 2013; 23(2): 86-89.

8. Wang JM, Ma CJ, Ji XJ, Wu XY, Wang KS, Thayer P, Moorman JP, Yao ZQ. Differential regulation of IL-12/IL-23 by Tim-3 drives TH17 cell development during HCV infection. Journal of Virology. 2013; 87(8): 4372-83.

9. Zuo L, Wang KS, Zhang XY, Krystal JH, Li CR, Zhang F, Zhang H, Luo X. NKAIN1�SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. Drug and Alcohol Dependence. 2013; 129(3): 254-64.

10. Zuo L, Saba L, Wang KS, Zhang X, Krystal JH, Tabakoff B, Luo X (2013) Exome-wide association study of replicable nonsynonymous variants conferring risk for alcohol dependence. Journal of Studies on Alcohol and Drugs. 2013; 74(4):622-5.

11. Zuo L, Wang KS, Zhang XY, Pan X, Wang G, Tan Y, Zhong C, Krystal JH, State M, Zhang H, Luo X (2013) Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. Human Genetics. 2013; 132(7):735-43.

12. Wang KS*, Liu X, Zheng S, Zeng M, Pan Y, Callahan K. A novel locus for body mass index (BMI) on 5p15.2: a meta-analysis of two genome-wide association studies. Gene. 2012; 500(1):80-4 (Has been cited for 1 time).

13. Wang KS*, Liu X, Aragam N, Jian XQ, Mullersman JE, Liu YL, Pan Y. Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence. Journal of Molecular Neuroscience. 2012; 46(2):265-71.

14. Wang KS*, Liu X, Zhang Q, Zeng M. ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies. Drug and Alcohol Dependence. 2012; 124(3):325-332.

15. Wang KS*, Liu X, Zhang QY, Aragam N, Pan Y. Parent-of-origin effects of FAS and PDLIM1 in attention-deficit hyperactivity disorder (ADHD). Journal of Psychiatry and Neuroscience. 2012; 37(1): 46-52 (Has been cited for 2 times).

16. Wang KS*, Liu X, Zhang Q, Wu LY, Zeng M. Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms. Journal of Neural Transmission. 2012; 119(4):425-433 (Has been cited for 7 times).

17. Wang KS*, Zhang Q, Liu X, Wu LY, Zeng M. PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies. Journal of Molecular Neuroscience. 2012; 48(1): 265-72 (Has been cited for 2 times).

18. Moorman JP, Wang JM, Zhang Y, Ji XJ, Ma CJ, Wu XY, Jia ZS, Wang KS, Yao ZQ. Tim-3 pathway controls regulatory and effector T cell balance during HCV infection. Journal of Immunology. 2012; 189(2):755-766 (Has been cited for 8 times).

19. Wang KS*, Liu X, Aragam N, Jian XQ, Mullersman JE, Liu YL, Pan Y. Family-based association analysis of alcohol dependence in the COGA sample and replication in the Australian twin-family study. Journal of Neural Transmission. 2011; 118(9):1293-1299 (Has been cited for 9 times).

20. Wang KS*, Liu X, Zhang QY, Aragam N, Pan Y. Genome-wide association analysis of age at onset in schizophrenia in a European-American sample. American Journal of Medical Genetics. Part B Neurophychiatric Genetics. 2011; 156(6): 671-680 (Has been cited for 4 times).

21. Wang KS*, Liu X, Zhang QY, Pan Y, Aragam N, Zeng M. Meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence. Journal of Psychiatric Research. 2011; 45(11): 1419-25 (Has been cited for 20 times).

22. Aragam N, Wang KS*, Pan Y. Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples. Journal of Affective Disorder. 2011; 133(3): 516-521 (Has been cited for 8 times).

23. Jian XQ, Wang KS*, Wu TJ, Hillhouse JJ and Mullersman JE. Association of ADAM10 and CAMK2A polymorphisms with conduct disorder in the COGA sample: evidence from family-based studies. Journal of Abnormal Child Psychology. 2011; 39(6):773-782 (Has been cited for 2 times).

24. Liu X, Wang KS, Lee K. Association of standardized estimated glomerular filtration rate with the prevalence of hypertension among adults in the United States. Journal of Human Hypertension. 2011; 25(8):469-475 (Has been cited for 1 time).

25. Pan Y, Wang KS*. Spousal concordance in academic achievements and IQ: A principal component analysis. Open Journal of Psychiatry. 2011; 1(2):15-19.

26. Pan Y, Wang KS*, Aragam N. NTM and NR3C2 polymorphisms influencing intelligence: family-based association studies. Prog Neuropsychopharmacol Biol Psychiatry. 2011; 35(1): 154-160 (Has been cited for 5 times).

27. Wang KS*, Liu X, Aragam N. A genome-wide meta-analysis identifies loci associated with schizophrenia and bipolar disorder. Schizophrenia Research. 2010; 124(1-3):192-9 (Has been cited for 34 times).

28. Wang KS*, Mullersman JE, Liu X. Family-based association analysis of MAPT gene in Parkinson disease. Journal of Applied Genetics. 2010; 51(4):509-14 (Has been cited for 2 times).

29. Walker EJ, Hirschfield GM, Xu C, Lu Y, Liu X, Coltescu C, Wang KS, Newman WG, Bykerk V, Keystone E, Amos CI, Heathcote EJ and Siminovitch KA. CTLA-4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population. Arthritis & Rheumatism. 2009; 60(4): 931-937 (Has been cited for 32 times).

30. Wallis RH, Wang KS (co-first author), Dabrowski D, Marandi L, Ning T, Murphy T, Hsieh E, Paterson AD, Poussier P. Type 1 diabetes in the BB rat: a polygenic disease. Diabetes. 2009; 58(4): 1007-1017 (Has been cited for 34 times).

31. Wu LY, Chipman HA, Bull S, Briollais L, Wang KS. A Bayesian segmentation approach to ascertain copy-number variations at the population level. Bioinformatics. 2009; 25(13):1669-1679 (Has been cited for 14 times).

32. Xu C, Li PP, Cook RG, Parikh SV, Wang KS, Kennedy JL, Warsh JJ. TRPM2 variants and bipolar disorder risk: confirmation in a family-based association. Biploar Disorder. 2009; 11(1): 1-10 (Has been cited for 23 times).

Scientific Activities

PROFESSIONAL MEMBERSHIPS

� American Society of Human Genetics (ASHG) (2004-present)

� International Genetic Epidemiologic Society (IGES) (2004-present)

� The International Biometric Society (IBS) (2007-present)

� American Public Health Association (APHA) (2009-present)

� The Institute of Quantitative Biology (IQB), ETSU (2009-present)


Rui ChenPhD

Postdoctoral Fellow
Department of Genetics
Stanford University School of Medicine
Address:USA
Biography

Dr. Rui Chen completed his Ph.D. at Yale University in 2008 with the John Spangler Nicholas Prize, a prestigious award for most outstanding Ph.D. candidates in Biology, and is currently a Postdoctoral Scholar training with Dr. Michael Snyder at Stanford University.

Research Interests

Dr. Chen has extensive experience in disease-related research and disease-orientated technology development, and is spearheading personalized health monitoring and preventative medicine with next-generation, high-throughput technologies.

Publications
Scientific Activities

Akin TekcanPhD

Assistant Professor
Medical Biology and Genetic
Ahi Evran University
Address:Turkey
Biography

Dr. Akin TEKCAN is currently working as assistant professor at Ahi Evran University, Health School, Kirsehir, in Turkey. He received his master and PhD degree from OndokuzMayis University, Faculty of Medicine, Department of Medical Biology, Samsun, Turkey. He has authored in many peer-reviewed scientific publications in national and international journals and is currently on the Reviewer Board of several scientific Journals.During master and PhD,he has worked about preimplantation genetic diagnosis technics, molecular basis and molecular diagnosis of diseases. His research focus on the genetic toxicity and genetic diagnosis techniques used at diagnosis of diseases.

 

Research Interests

Preimplantation genetic diagnosis
The molecular basis and diagnosis of diseases.
Genetic toxicity

Publications
Scientific Activities

Edward EsplinPhD


Department of Genetics
Stanford University School of Medicine Stanford
Address:USA
Biography

Dr. Esplin received his MD and PhD in Genetics and Development at the University of Texas Southwestern Medical Center at Dallas. He completed Internal Medicine residency at UT Southwestern and Medical Genetics fellowship at Stanford University. Currently he is working as a Clinical Scholar and is the Tashia and John Morgridge Endowed Fellow in the Department of Genetics at Stanford University. His research is focused on the genomic, transcriptomic and proteomic analysis of familial adenomatous polyposis (FAP), a genetic colon cancer syndrome, in comparison with sporadic colon adencarcinoma.

Research Interests

Application of genomic, transcriptomic and proteomic analyses to heritable and sporadic genetic disorders, with the goal being to define the alteration or accumulation of alterations that lead to disease phenotype, identifying novel biomarkers for the early detection and classification of disease severity and prognosis, and elucidation of targets for therapeutic and preventional intervention. Longer term interests include serum cell free DNA analysis for early diagnosis and staging of pre-malignancy, preventional gene-directed therapeutic intervention for monogenic and complex genetic disorders and high throughput functional analyses of genetic variants of unknown significance generated by whole genome sequencing.

Publications
Scientific Activities

Zhengyu CaoPhD

Project Scientist
Department of MolecularBioSciences
University of California
Address:USA
Biography

Dr. Zhengyu Cao completed his Ph.D. at Peking Union Medical College& Chinese Academy of Medicinal Science in 2004. He was trained later in the University of Georgia as a Post-doc. He worked in the Creighton University, School of Medicine as an Assistant Professor between 2009-2010. Currently Dr. Cao is a senior scientist in the Department of Molecular Biosciences in the University of California, Davis.

Research Interests

Utilizing stem cell technologies and genetic mouse models, Dr. Cao is focusing on the understanding the mechanisms of neuron development disorders and how the environmental risk factor accelerating the occurrence and progression of the disorders.Utilizing high through-put assays, Dr. Cao is also interested in discovering target specific small molecules which may have better intervention on the neurological disorders.

Publications
Scientific Activities

Boxun LuPhD

Professor
School of Life Sciences
Fudan University
Address:China
Biography

Boxun Lu received his PhD in cell biology and physiology from the University of Pennsylvania, USA. Currently, he is working as a Professor at the School of Life Sciences, Fudan University. His research interests focus on genetics and cell biology in neurodegenerative disorders.

Research Interests

Neurodegenerative disorders, polyQ diseases, stem cell derived neurons, high-throughput technologies, protein degradation, target identification, mechanism of action studies, disease relevant genetics, RNAi screenings, phenotypic screenings, mouse models for genetic diseases.

Publications
Scientific Activities

Muhammad RafiquePhD


Department of Child Health
College of Medicine King Khalid University
Address:Abha, Saudi Arabia
Biography

Muhammad Rafique received his membership (MCPS) in 2002 and fellowship (FCPS) in 2003 in pediatrics from College of Physicians and Surgeons Pakistan. He worked for 5 years as a Senior Registrar / Assistant Professor in Services Institute of Medical Sciences, University of Health Sciences Lahore, Pakistan. Now he is working as an Assistant Professor in Department of Child Health in King Khalid University since 2009 and teaching genetics for last 4 years. His research focuses on genetic disorders and associated syndromes.

Research Interests

He has extensive research on propionic acidemia and many other syndromes. He is interested in research on diagnosis of heritable & sporadic genetic disorders and associated syndromes, prophylactic screening and genetic counseling, preventive pediatrics, chronic childhood diseases like tuberculosis, hematological genetic disorders, diabetes mellitus, infectious and neonatal diseases.

Publications
Scientific Activities

Patr�cia Fernanda SchuckPhD

Professor
Academic Unit of Health Sciences
University of the Extreme South of Santa Catarina
Address:Brazil
Biography

I, Patr�cia Fernanda Schuck, have the academic degree of Pharmacist issued by the Universidade Federal do Rio Grande do Sul, Brazil, in 2003 and the MSc and PhD by the Biochemistry Department of the Universidade Federal do Rio Grande do Sul, Brazil, in 2005 and 2009, respectively.

Since my first year at the Faculty of Pharmacy, I have been working in the field of Inherited Metabolic Diseases under the direct coordination of Prof. Dr. Moacir Wajner at the Inborn Errors of Metabolism Group, at the Biochemistry Department of the Universidade Federal do Rio Grande do Sul, Brazil. During my stay at Prof. M. Wajner�s research group, I had the opportunity to participate in National and International Congresses and submitted research works for presentation as posters and oral communications. I have also been involved in several Basic Research Projects related to energy metabolism, oxidative stress, and behavioural studies in animal models in the field of inborn errors of metabolism. Since May 2009 I have a position in a Post-Graduate Program in Health Sciences at Universidade do Extremos Sul Catarinenes. Currently, my laboratory encompasses 8 undergraduate students, 2 MSc Students and 6 PhD students working under my supervision. Some of the results emerged from them and from collaborative works with my former laboratory have already been published in high-impact scientific journals.

Research Interests

Inherited Metabolic Diseases, energy metabolism, oxidative stress, and behavioural studies in animal models in the field of inborn errors of metabolism.

Publications
Scientific Activities

Chang XiaoPhD

Postdoctoral Fellow
Center for Applied Genomics
The Children's Hospital of Philadelphia
Address:USA
Biography

Xiao Chang completed his Ph.D. of bioinformatics at Chinese Academy of Sciences in 2010.  Soon afterwards, he was funded by ZNI Young Scholar Program to work as a postdoctoral fellow at University of Southern California. Since 2013, he has been workingas a senior postdoctoral fellow in the Center for Applied Genomics at The Children’s Hospital of Philadelphia. Dr. Chang has a strong background in computer science and molecular biology. His research interests include software development, NGS data analysis, population genetics, comparative genomics, systems biology. His research results has been published in various international scientific journals, such as Cell Research, Human Molecular Genetics, Journal of Medical Genetics, Plos Computational biology and Bioinformatics etc. He developed the web server wANNOVAR, which has been widely used by researchers working with NGS data. He has also been invited as a reviewer from Plos One, BMC Cancer, BioMed Research International etc. 

Research Interests

Develop bioinformatics pipelines and computational biology algorithms for next-generation sequencing data. 

Develop network-based pathway analysis methods for post-GWAS analysis of psychiatric disorders

Apply integrative genomics methods (including GWAS analysis, CNV analysis, gene expression analysis) on cancers for gene discovery.

Publications
Scientific Activities

Antonios KerasnoudisPhD

Department of Neurology
St. Josef Hospital
Ruhr University
Address:Germany
Biography

Dr. Kerasnoudis was born in Serres, Greece in 1983. In 2007, he graduated from the Medical School of the Aristotle University in Thessaloniki, Greece. In 2009, he began his neurological residency in the Department of Neurology of the St. Josef Hospital, Ruhr University, Bochum in Germany. He is board certified for neuromuscular ultrasound and extracranial-intracranial Doppler ultrasound from the German and European Neurosonology Society. His clinical and research work focuses on the applications of ultrasound in clinical practice.

Dr. Kerasnoudis is the principal investigator of various nerve ultrasound studies on immune-mediated neuropathies. His main scientific contributions are the detection of possible distribution patterns of pathological nerve ultrasound changes in immune-mediated neuropathies, such as the Guillain�Barr� syndrome (GBS), the multifocal motor neuropathy (MMN) and the chronic inflammatory demyelinating polyneuropathy (CIDP). His nerve ultrasound group based in Bochum, Germany, introduced for the first time in the literature a novel ultrasound score (Bochum Ultrasound Score), allowing the differentiation of the CIDP from GBS in the acute/subacute phase.

Dr. Kerasnoudis is coauthor of two books on neuromuscular ultrasound and author of many peer-reviewed original articles. He is member of the German and Greek Neurological Society and enlisted in the reviewer list of several journals of international repute.

Research Interests

Applications of ultrasound in clinical practice
Neuromuscular ultrasound in neuropathies

Publications
Scientific Activities

Chen SUOPhD

Research Assistant
Center for Molecular Epidemiology

Address:Singapore
Biography

Chen Suo is a postdoc in the Center of Bioinformatics at Peking University.

Chen completed her Ph.D at Karolinska Institutet and his undergraduate studies at National University of Singapore. Her research interests lie in the area of biostatistics, ranging from statistical methodology development to application, with a focus on high-throughput data analysis. In recent years, she has focused on improved statistical methods for detecting, analysing and integrating different types of molecular data in the human genome and transcriptome. She has collaborated actively with researchers in several other disciplines, particularly epidemiology. Chen worked as a research assistant in Center for Molecular Epidemiology from 2008 to 2011.

In her spare time, Chen enjoys yoga, watching ballet performance, travelling, reading novels and playing with cats.

Research Interests

Identifying the statistical problems in analysing large-scale biological data, including mRNA and microRNA array, whole genome DNA and RNA sequencing data, which can be used to identify mutations, copy number variations, gene and isoform-level expression quantification

Publications
Scientific Activities

Baodong SunPhD

Assistant Professor
Division of Medical Genetics
Duke University
Address:USA
Biography

Dr. Baodong Sun was born in 1966 in the famous "Ice City" Harbin in northeastern China. He obtained both his bachelor and master degrees in molecular biology and biochemistry, and a Ph.D. degree in cell biology. Shortly after getting his Ph.D., Dr. Sun came to the US in early 1997 to continue his career in cancer research at Tulane University School of Medicinein New Orleans, under the supervision of Professor Andrew Schally, a Nobel Laureate in Medicine. Dr. Sun joined Department of Pediatrics, Division of Medical Genetics at Duke University in 2001 and since then, he has been working on development of effective therapy for human glycogen storage diseases. Dr. Sun is currently an Assistant Professor at Duke Medical Center with expertise ingene therapy and enzyme replacement therapy for human genetic disorders.

Research Interests

My research interests are in translational research for human genetic disorders. The main focus of my research is to generate animal models and develop effective therapies for human glycogen storage diseases (GSDs), including GSD II (Pompe disease), GSD III (Cori disease), and GSD IV (Andersen disease). Another interest of my research is to study the function of a novel protein starch binding domain containing protein 1 (Stbd1) in glycogen metabolism and its role in GSDs

Publications
Scientific Activities

Chunyu LiuPhD

Assistant professor
Biostatistics Departmen
Boston University
Address:United States
Biography

Chunyu is a statistical geneticist in the Framingham Heart Study, NHLBI. She also has a joint appointment as an assistant professor and teaches courses in the Biostatistics Department of Boston University. Her research focuses on several areas, including maternal inheritance and the effects of mitochondrial DNA mutations in common phenotypes; DNA methylation in relation to alcohol consumption and related diseases; genome-wide association analysis of complex phenotypes. She earned her PhD in Biostatistics from Boston University.

Research Interests

Maternal inheritance and the effects of mitochondrial DNA mutations in common phenotypes.
Design and conduct genetic studies in clinical trials.
Statistical methodologies in gene expression and epigenetics/metabolomics.

Publications
Scientific Activities

Masa-Aki ShibataPhD

Professor
Laboratory of Anatomy and Histopathology
Osaka Health Science University
Address:Japan
Biography

Dr. Shibata is a professor in Graduate School of Health Sciences, Osaka Health Science University, Osaka, Japan. He obtained doctor degree of medical sciences from Graduate School of Medical Science, Nagoya City University, Nagoya, Japan. After this he investigated cancer gene therapy and cancer prevention in National Institutes of Health, USA (1994-1999). He was awarded at the title of NIH Fellows Award for Research Excellence in 1999. Then, he became an associate professor in Osaka Medical College, Osaka, Japan and conducted cancer research and medical education at this medical college in 1999-2011.He has over100 publicationsand is currently on the editorial board of several scientific journals.

Research Interests

Cancer gene therapy, cancer prevention, metastasis inhibition, complementary alternative medicine, angiogenesis and lymphogenesis. In order to search it, please input �mashibata� in PubMed.

Publications
Scientific Activities

Dan ChenPhD

Researcher
Department of Immunology
Uppsala Uppsala University
Address:Europe
Biography

My current research interests are in the field of genetics of cancer and other complex traits, with a focus on identifying genetic determinants for cancer risk and response to therapy and dissecting gene-environment interactions as well as gene-gene interactions in the etiology of cancer by using statistical analysis and correlative laboratory studies to elucidate their functional relevance with genetic susceptibility to complex human traits. More specifically, the research is focused on the following areas: 1) identification and confirmation of new genetic variants that explain the genetic susceptibility to cancer and different response to therapy through candidate gene studies and genome-wide association studies; 2) assessment of gene-environment interactions for cancer development, progression and prognosis. The goal of my research is to develop the personalized medicine of cancer and thereby to contribute to establishment of evidence-based genomic medicine.

Research Interests

Cancer
Complex traits
Genetics
Genomics
Epidemiology

Publications
Scientific Activities

Gustavo da Costa FerreiraPhD

Professor
Academic Unit of Health Sciences
University of the Extreme South Catarinense
Address:Brazil
Biography

I, Gustavo da Costa Ferreira, have the academic degree of Pharmacist issued by the Federal University of Rio Grande do Sul, Brazil, in 2002, and the MSc Degree by the Department of Biochemistry of the Federal University of Rio Grande do Sul, Brazil, in 2005.

From 2000, until 2009 I worked in the field of inherited metabolic diseases under the direct coordination of Prof. Dr. Moacir Wajner. I started working with diagnosis of organic acidurias and aminoacidopathies at the Medical Genetics Service of the Hospital de Cl�nicas de Porto Alegre. From 2003 to 2009, I performed my MSc and PhD at the Inborn Errors of Metabolism Group, at the Department of Biochemistry of the Universidade Federal do Rio Grande do Sul, Brazil. Since 2009 I have a position as Full Professor in the Post-Graduate Program in Health Sciences at Universidade do Extremo Sul Catarinense. At present, there are in my laboratory 5 undergraduate students, 3 MSc Students and 3 PhD students working under my supervision. Some of the results emerged from them and from collaborative works have already been published in high-impact scientific journals.

Research Interests

My interests are inborn errors of metabolism, mitochondria, bioenergetics and neurotransmission.

Publications
Scientific Activities

G�nter AuerswaldPhD

Professor
Children's Hospital in Bremen

Address:Germany
Biography

Dr. Auerswald is currently Head of the Department for Comprehensive Care in Haemostasis and Thrombosis at the Children's Hospital in Bremen. His main research interests lie in blood coagulation and concentrate on rare blood disorders such as von Willebrand disease as well as factor VII and factor X deficiencies. He has over 20 years of experience in clinical studies of haemostaseology, viral safety, von Willebrand concentrates and anti-epileptic drugs. He is internationally renowned for the treatment of inhibitors and has published extensively on this subject.

Dr. Auerswald is a member of the major associations of haemophilia, including the American Society of Haemostasis and the International Society of Thrombosis and Haemostasis.

Research Interests

His main research interests lie in blood coagulation and concentrate on rare blood disorders such as von Willebrand disease as well as factor VII and factor X deficiencies.

Publications
Scientific Activities

Dong LiPhD

Senior Scientist
Institute of Sericulture and Systems Biology
Southwest University
Address:USA
Biography

Dong Li received his Ph.D. in Genomics and Bioinformatics from the Southwest University, China in 2011. Then he completed his postdoc training in Center for Applied Genomics (CAG), Children’s Hospital of Philadelphia (CHOP) in 2014. Currently he is working as a Senior Scientist at CAG/CHOP, focusing on resolving the genetic causes of complex diseases of unknown etiology (most of which are rare) using whole exome sequencing.

Research Interests

Human genetics
Functional genomics
Translational research

Publications
Scientific Activities

Vita GolubovskayaPhD

Associate Professor of Oncology
Surgical Oncology
Roswell Park Cancer Institute
Address:USA
Biography

Vita Golubovskaya, Ph.D. is Associate Professor of Oncology, Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY. Dr. Golubovskaya graduated from St. Petersburg State University and received her Ph.D. in cell biology from the Institute of Cytology (St. Petersburg, Russia). She completed extensive post-doctoral training in cancer research at St. Jude Children�s Research Hospital, Memphis, TN and at Lineberger Comprehensive Research Cancer Center, UNC, NC. Dr. Golubovskaya is the author and co-author of more than 70 peer-reviewed papers, and book chapters in cancer research. She served as the Managing Editor and guest Editor for the Frontiers in Bioscience and Anti-Cancer Agents in Medicinal Chemistry Journals. Dr. Golubovskaya is an Editorial Board Member of several international peer-reviewed journals. She is an active member of the American Association of Cancer Research (AACR) and the American Association of Advancement of Science (AAAS). In 2005, Dr. Golubovskaya obtained the World Scientist Forum International Award in Cancer Research and in she won a prestigious award in breast cancer research and a three-year grant from the Susan G. Komen for the Cure Breast Cancer Foundation. Dr. Golubovskaya holds 6 patents on cancer therapeutics.

Research Interests

Dr. Golubovskaya�s interests include different aspects of cancer research, cell proliferation, motility, adhesion, apoptosis, gene regulation, signal transduction pathways and developing novel therapeutics.Dr. Golubovskaya�s research team is focused on the role of Focal Adhesion Kinase (FAK) in survival pathways. Dr. Golubovskaya cloned and characterized the FAK gene promoter region and found binding sites for NF-kappa B and tumor suppressor p53 in the FAK promoter. In 2005, Dr. Golubovskaya discovered the direct interaction of FAK and p53 proteins. She also discovered binding of FAK and EGFR and found that dual targeting of FAK and EGFR or FAK and Src is efficient to block cancer. She is developing novel small molecule compounds to target Focal Adhesion Kinase in cancer cells.

Publications
Scientific Activities

Fatima SmagulovaPhD

Avenir group leader

University of Rennes 1
Address:Russia
Biography
Research Interests

Genetic of human diseases
Epigenetics
Reproduction
Meiosis
Toxicology
Development

Publications
Scientific Activities

Travis ThompsonMD, PhD

Professor
Department of Educational Psychology
University of Minnesota
Address:USA
Biography

PhD Psychology (Behavior Analysis, child development and neuroscience) Univ of Minnesota; Postdoctoral Fellow Univ of Maryland (Psychopharmacology), Special PostDoc Fellow Cambridge University (ethology and behavior analysis).Assist to Full Prof. in Psychology, Psychiatry, Pharmacology, Special Education,Univ of Minnesota 1963-1969.DirNeuroBehavioral Pharmacology Training program 1967-1990.Professor and Dir. John F. Kennedy Center Vanderbilt Univ. 1990-2000. Smith Prof of Psychiatry, Univ of Kansas Med. Center 2000-2003; PI NICHD Mental Retardation Research Center, Vanderbilt University; NICHD Program Project �PraderWilli Syndrome Genetics and Behavior,� with Merlin Butler, MD, PhD, Vanderbilt Univ.; Consulting scientist, Kennedy Krieger Institute, Johns Hopkins, and Eunice Kennedy ShriverCenter U Mass. Appointed positions include NICHD Consensus Panel on Destructive Behavior in Developmental Disabilities, Bethesda, MD; Past chair NICHD Research Review Panels on Autism Centers of Excellence, and chair of the NICHD MRRD Center Director�s Committee; AMAPanel on CPT Codes for ABA treatment of young children with autism [Ad Hoc Member]; AmerPsycholAssn Division 25 Don Hake Award for contributions in bridging basic and appl. Research; Past, Pres, Div 33, Mental Retardation and Developmental Disabilities of APA; Distinguished Research Award, Academy of Mental Retardation, Career Scientist Award; Impact of Science on Application Award, Society for the Advancement of Behavior Analysis.

Research Interests

Autism, PraderWilli syndrome; behavior disorders in autism and developmental disabilities; behavioral pharmacology, experimental and applied behavior analysis.

Publications
Scientific Activities

Hongying DaiPhD

Assistant Professor
Department of Biomedical & Health Informatics
University of Missouri-Kansas
Address:United States
Biography

Dr Dai received her PhD in statistics from University of Kentucky. She currently is an Assistant Professor at Children’s Mercy Hospital, with a joint appointment from Department of Biomedical & Health Informatics at University of Missouri-Kansas City. She has co-authored more than 40 scientific publications and participated in multiple NIH funded research projects.

Research Interests

Microarray Data Analysis
Multiple Comparison Adjustment
Mixture Modeling
Genome Wide Association Study (GWAS)
Multifactor Dimensionality Reduction (MDR)
Semiparametric modeling
Genetic Analysis of Complex Traits and Meta Analysis

Publications
Scientific Activities

Nelson S YeeMD, PhD

Assistant Professor
Medicine
Pennsylvania State University
Address:USA
Biography

Nelson S. Yee, M.D., Ph.D. is a physician-scientist-educator at Penn State Hershey Cancer Institute, where he is Director/Principal Investigator of Laboratory of Pancreatic Development and Cancer as well as Attending/Consultant Physician of Medicine in Medical Oncology. Dr. Yee received dual Bachelor degrees of Science in Pharmacy and Chemistry at Massachusetts College of Pharmacy in Boston. He then pursued medical education and graduate training at Cornell University Medical College and Memorial Sloan-Kettering Cancer Center in New York City. He underwent post-graduate clinical training in Internal Medicine and Hematology-Oncology at Hospital of University of Pennsylvania in Philadelphia. He was appointed Instructor in Medicine at University of Pennsylvania, and then Assistant Professor of Medicine at University of Iowa in Iowa City. Currently, Dr. Yee is Assistant Professor of Medicine at Pennsylvania State University College of Medicine, and he is Course Director of Clinical Elective in Medical Oncology, Acting Internship in Medical Oncology, and Medicine Clerkship in Medical Oncology. He is Guest Editor and Editorial Board Member for scientific and medical journals. He has published original research articles, reviews, case reports, commentaries, and book chapters; and he presented at research conferences in China, Hong Kong, Germany, and America. He has been Principal Investigator of clinical trials to evaluate new treatment for patients with digestive organs cancer.

Research Interests

Developmental biology and genetics of exocrine pancreas in zebrafish. Biomarkers and targets for personalized therapy in human pancreatic cancer. Clinical investigation for treatment of patients with malignant diseases in digestive organs.

Publications
Scientific Activities

Raj KumarPhD

Professor
Department of Basic Sciences
The Commonwealth Medical College
Address:USA
Biography

Dr. Kumar is currently a Professor of Biochemistry at The Commonwealth Medical College (TCMC), Scranton, PA, USA. He received his Ph.D. from University of Lucknow, Lucknow, India, and post doctoral training at University of Texas Medical Branch (UTMB), Galveston, TX, USA. Before moving to TCMC, he held position of Associate Professor in the Department of Internal Medicine at UTMB. Dr. Kumar�s current area of research is focused on the role of intrinsically disordered activation domain of transcription factors in the gene regulation. He serves as an editorial board member of about a dozen other international peer reviewed journals, and has served as scientific reviewer for more than 40 peer-reviewed journals. He has also served on numerous national and international scientific review panels. He has over 90 publications including peer-reviewed scientific journals, a book and several book chapters and a patent, and has been invited to speak at several international scientific meetings and research institutes/universities.

Research Interests

Protein structure and functions; Macromolecular interactions; Cell signaling and Gene regulation; Cancer; Endocrinology; Steroid hormone receptors; Post translational modifications; Neurodegenerative diseases; Structure-based drug discovery

Publications
Scientific Activities

Hui-Xin LiuPhD

Project Scientist
Department of Medical Pathology
University of California
Address:United Kingdom
Biography

Hui-Xin Liu received his Ph.D. in Biochemical Engineering at Dalian Institute of Chemical Physics, Chinese
Academy of Sciences, China. Currently, he is working at the Department of Pathology & Laboratory Medicine, UC Davis. His research interests focus on the effects of alcohol, hepatitis virus, and high fat diets on the liver. 

Research Interests

Study the pathophysiology of the liver with specific interests in understanding the mechanism underlying the development of metabolic syndromes, fatty liver, fibrosis, cirrhosis, and liver cancer. The goal is to identify potential therapeutic targets in the prevention and treatment of liver disease.

Publications
Scientific Activities

Steven Waldman DPhD

Clinical Professor
City School of Medicine
University of Missouri-Kansas
Address:USA
Biography

Steven D. Waldman, a pioneer in the specialty of pain management, has served as a mentor, innovator,and teacherfor an entire generation of pain management specialists. He graduated from the UMKC School of Medicine in 1977 and began his residency in Anesthesiology at the Mayo Clinic in Rochester, Minnesota. The numerous textbooks Waldman has authored have become the standard texts for the specialty of pain management and they have re-defined how pain management is written about and taught. A tireless advocate for the specialty, Waldman was one of the first physicians in the United States to engage in the full-time private practice of pain management and was among the first to advance the idea that pain management was a specialty in and of itself rather than a small part of another specialty. He firmly believed that the specialty deserved its own training programs, literature, and its own clear path to board certification. Waldman served in numerous leadership positions while in training at Mayo and in 1979 was elected by his peers to the post of Fellows Association President, representing almost 2000 Mayo residents and interns who comprised the Mayo Housestaff. While at Mayo� Waldman also served as Editor-In-Chief of the Fellowsope, the Mayo Clinic housestaff newsletter as well as Fellows Association Social Activities Chairman for the housestaff.

Research Interests

Headache Physical Diagnosis
Interventional Pain Management
Facial Pain
Ultrasound Guided Interventional Pain Management Procedures

Publications
Scientific Activities

Jyoti BhardwajPhD




Address:India
Biography

I did my Ph.D. in biochemistry from Punjab Agricultural University (PAU), Ludhiana, India in 2007. My master’s degree is also in biochemistry from CSK HPKV, Palampur, India. Later, I joined for post doctoral experience in the laboratory of Dr. Sudesh Kumar Yadav at CSIR-IHBT, Palampur, Himachal Pradesh, under women scientist scheme (WOS-A)  of Department of Science and Technology (DST), Government of India, India.

Research Interests

I have experience in areas related to plant abiotic stress tolerance, biochemistry, proteins and proteomics, genomics, epigenetics and molecular biology. Further, I will venture into the areas of Systems Biology with interactome studies and small RNA world with sRNAome studies.

Publications
Scientific Activities

Anastasios LymperopoulosPhD

Assistant Professor
Department of Pharmaceutical Sciences
Nova Southeastern University
Address:USA
Biography

My career started by earning M.Sc. in Medicinal Chemistry followed by Ph.D. in Pharmacology, after graduating from the School of Pharmacy of the University of Patras, Greece. Its major turning point was in 2004, when I joined the lab of Dr. Walter Koch, a former postdoctoral fellow of Nobel laureate Professor Robert Lefkowitz`s lab at Duke University. During my 5-year postdoctoral tenure there, I had several successes, awards and honors, most prominent among which being a lead-author publication in �Nature Medicine� and a 4-year Scientist Development Grant award by the American Heart Association (AHA) I currently hold. In addition, I have been a post-doctoral research fellow of the AHA for a total of three years in the past, and, in fact, my postdoctoral fellowship application with AHA in 2007 got an unusual 1-year extension based on its exceptionally high score. I have also been a finalist for the AHA-sponsored Melvin L. Marcus Young Investigator Award in Basic Cardiovascular Sciences, and for the Cardiovascular Research Award of the Council on Basic Cardiovascular Sciences of the European Society of Cardiology (ESC), I hold two (provisional) research patents, and I currently serve on the Editorial Boards of two peer-reviewed journals, as a regular peer-reviewer for several prestigious journals, including �British Journal of Pharmacology�, "Circulation Research", and �American Journal of Cardiology�, and as a research grant reviewer for AHA. In addition, I am an elected Fellow of the American Heart Association (FAHA) and its Council on Basic Cardiovascular Sciences (BCVS). Finally, I have published in various prestigious scientific journals, in addition to �Nature Medicine�, such as: Circulation, JACC, PNAS, JBC, Molecular Pharmacology, etc. and my papers are highly cited.

Research Interests

Molecular pharmacology, physiology and biology of G protein-coupled (heptahelical or seven transmembrane-spanning) receptors (GPCRs); Heart Failure; Cardiovascular Disease; Neurohormonal control of the Circulation; Adrenal Physiology and Pharmacology; Receptors for Adrenaline and Noradrenaline; Catecholamines; Receptors for Angiotensin II; Signal Transduction; Gene Therapy; Transgenic mice and rats; Aldosterone production regulation; Regulation of Adrenergic and Angiotensin Receptors; G protein-coupled receptor Kinases (GRKs); Beta-Arrestins; Novel �Biased� G protein-coupled Receptor Ligands; Pharmacogenomics and pharmacoproteomics of cardiovascular GPCRs, GRKs and beta-arrestins.

Publications
Scientific Activities

Kuo Chu HwangPhD

Professor
Department of Chemistry
National Tsing Hua University
Address:China
Biography

Kuo Chu Hwang received his bachelor’s degree in Chemistry from National Cheng Kung University, Taiwan, in 1981, master degree in Chemistry from National Tsing Hua University, Taiwan, in 1983, and Ph. D. degree in Chemistry from Columbia University, USA, in 1990 under the supervision of professor Nicholas J. Turro.  Professor Hwang joined the National Tsing Hua University as an associate professor in 1993, and was promoted as a professor in 2000. His research interests include nanomaterials, enzyme kinetics, and photochemistry.  In particular, his recent research was focused on the application of various nanomaterials as NIR light activatable photodynamic therapy (NmPDT) and photothermal therapy (NmPTT) agents for destruction of cancer cells/tumors, NIR light activatable photocatalysis, using photochemical methods for C-H bond functionalization of hydrocarbons, and develop novel Cu(I)-catalyzed photochemical synthesis of various bio-medically active products via C-C, C-N, and C-S coupling.

Research Interests

Preparation, characterization and applications of nano-sized materials Carbon nanotubes, carbon onions, 

Enzyme kinetic, drug design, Photo and magnetic field effects on enzyme catalysis

Singlet Oxygen/ozone Photochemistry, Organic light emitting materials and devices (OLED), Nanomaterials-mediated Photodynamic Therapy (NmPDT) treatments of cancers.

Publications
Scientific Activities

Paris MargaritisPhD

Assistant Professor
Perelman School of Medicine
University of Pennsylvania
Address:USA
Biography

Dr. Margaritis completed his Doctor of Philosophy at the University of Oxford (U.K.) followed by his postdoctoral work at the Children�s Hospital of Philadelphia. He joined the faculty of the Perelman School of Medicine at the University of Pennsylvania in 2010 and he is currently a Research Assistant Professor of Pediatrics. Dr. Margaritis has presented his work at both national and international meetings and continues to serve as a reviewer for the leading journals in hemostasis and thrombosis. He is actively involved in the both Hematology as Gene Therapy societies.

Research Interests

We have extensive expertise in protein expression and characterization of coagulation proteins. Using hemophilia as a target disease, we seamlessly incorporated such coagulation proteins in gene transfer approaches using viral vectors. Our results exemplified the potential of using gene transfer as a novel therapeutic for coagulation defects. Ongoing work focuses on using basic biochemical, molecular as well as complex in vivo methodology within the field of coagulation with two goals: (1) to advance our understanding of molecular mechanisms involved in pro- and anti-coagulant reactions; (2) translational research for the treatment of coagulation defects. Despite their different endpoints, these goals exhibit remarkable cross-talk since clarification of mechanistic questions in coagulation may benefit the design of successful therapeutic approaches.

Publications
Scientific Activities

Pei Li YaoPhD


Department of Veterinary & Biomedical Science
Center of Molecular Toxicology & Carcinogenesis
Address:USA
Biography

Pei-Li Yao, Ph.D., received her Ph.D. in Cellular and Molecular Biology at the University of Texas at Austin in 2008. She is a biomedical scientist working at the intersection of reproductive toxicology and molecular carcinogenesis. Dr. Yao�s doctoral and first post-doctoral training in reproductive biology provided her with the technical and intellectual expertise essential to investigate reproductive toxicology. Currently Dr. Yao is a post-doctoral fellow in the Department of Veterinary & Biomedical Science and Center for Molecular Toxicology & Carcinogenesis at The Pennsylvania State University. Her present research focuses on investigating the role of peroxisome proliferator-activated receptor (PPAR) mediated signaling pathways in toxicology, carcinogenesis and homeostasis with the aim of making contributions to reproductive medicine and the etiology of testicular cancer.

Research Interests

Reproductive toxicology, Molecular carcinogenesis, Cell signaling, Gene regulation, Cell differentiation, Developmental biology.

Publications
Scientific Activities

Lan HuPhD

Medical Officer and Research Microbiologist
CFSAN
FDA
Address:China
Biography

She holds M.D. and PhD degrees with extensive knowledge in multiple fields including medicine, microbiology, biology, immunology and epidemiology. As a medical officer and microbiologist with over 20 years of laboratory and research experience in molecular biology, immunology, bacteriology, food safety, risk study and vaccine study in several research institutes, she initiated and completed numerous research projects that focused on the molecular mechanisms of bacteria-host interaction and genomic analysis, and pathogen detection methods. Collaborating with international and national experts and leaders in multidisciplinary experimental and theoretical teams, she gained independent thinking, analytical and problem-solving skills, and ability to understand, analyze and convey complex concepts in writing.  She provided strategic advice and supportive roles in multiple scientific writing and laboratory procedures, project design and presentation, as well as published research and review papers in peer-reviewed scientific journals.  She reviewed manuscripts for several scientific journals like Infection and Immunity, Food Protection and other journals.

Research Interests

Molecular pathogenesis
Gene expression and control mechanisms
Host-pathogen interactions
Signal transduction
Vaccine construction and testing
Drug discovery
Immunology
Rapid diagnostic techniques

Publications
Scientific Activities

Tohru IkutaMD, PhD

Professor
Anesthesiology and Perioperative Medicine
Comprehensive Sickle Cell Center Medical College o
Address:USA
Biography

Dr. Ikuta is currently a tenured Professor of the Department of Anesthesiology and Perioperative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, U.S.A. He received a M.D. degree from Kyushu University, Fukuoka, Japan, and Ph.D. from the Graduate School of Medical Science of the Kyushu University, Fukuoka, Japan. After trainings at the Beckman Research Institute of the City of Hope, Duarte, California, as a postdoctoral fellow, and the University of California San Francisco as Research Fellow of the Howard Hughes Medical Institute, he joined as Assistant Professor to the Department of Pharmacology of the Boston University School of Medicine. He has received multiple research grants from private foundations including the American Cancer Society, the American Heart Association and the Doris Duke Charitable Foundation as well as R01 and P01 grants from the National Institutes of Health, USA. Currently, he is an Editorial Board member of several journals in hematology and is serving as a regular member for the NIH study section of Molecular and Cellular Hematology. The research projects supported by NIH grants are: 1) mechanisms regulating the production of fetal hemoglobin that inhibits sickle formation by specifically focusing on intracellular signaling pathways, and 2) mechanisms underlying hydroxyurea resistance that is seen with sickle cell disease patients.

Research Interests

Anemic disorders such as sickle cell disease and the thalassemias, molecular basis of leukemia and other hematological disorders, development of stem cell therapies for hematological disorders, clinical application of nitric oxide for sickle cell disease, intracellular signaling mechanisms or signal transduction, iron overload.

Publications
Scientific Activities

Oscar Campuzano LarreaPhD

Post-doc fellow
Medical Science Department
University of Girona
Address:Spain
Biography

I was born in Barcelona (Spain) in 1977. I obtained my BSc degree at the University of Barcelona (Spain) in 2002. Five years after I obtained my PhD degree at the Autonomous University of Barcelona (Spain). In 2008 I was accepted into Clinical Cardiovascular Genetics Center, University of Montreal, Montreal (Canada), as a post-doc fellow in cardiovascular genetics program. After that, I moved to Girona (Spain) joining a post-doc position at Cardiovascular Genetics Center and an associate teacher position at Medical School (University of Girona). In order to improve my knowledge in sudden death pathologies, in 2010 I spend 6 months at Hôpital Robert Debré, Paris (France), and in 2013 at Istituto Medicina Legale e delle Assicurazioni, Facoltà di Medicina e Chirurgia, Università Cattolica del Sacro Cuore, Rome (Italy). The Cardiovascular Genetics Center is a laboratory dedicated to research in Sudden Cardiac Death, merging basic science with clinical medicine.

Research Interests

Human Biology
Human Genetics
Cardiac pathologies
Sudden Cardiac Death

Publications
Scientific Activities

Xin WangPhD

Assistant Professor
Brigham and Women�s Hospital
Harvard Medical School
Address:USA
Biography

Dr. Xin Wang is an Assistant Professor at Harvard Medical School and a Neruoscientist at Brigham and Women's Hospital, Boston, MA, USA. She received her BS from Liaoning Normal University, China, MS from the University of Science and Technology of China, China, and PhD from Hebrew University of Jerusalem, Israel. She did her postdoctoral training at University of Michigan and Harvard Medical School. Dr. Wang is a Visiting Professor of Weifang Medical University and Qingdao University, Shandong, China. Dr. Wang is the Guest Editor and Editorial Board Member in peer-reviewed journals and has served on international and national scientific review panels including NIH. Dr. Wang has published more than 50 peer-reviewed articles and a number of book chapters, and was post hoc reviewer for 23 peer-reviewed journals. She has served in the National Scientific Advisory Council of American Federation for Aging Research and Harvard Medical Area Standing Committee on Animals. Dr. Wang is a recipient of the Hereditary Disease Foundation Fellowship, and the Principal Investigator in numerous grants from NIH/NINDS, Muscular Dystrophy Association, Bill & Melinda Gates Foundation, and the ALS Therapy Alliance, Inc.

Research Interests

Dr. Wang�s research interests focus on the identification of therapeutics, biomarkers and potential targets for therapeutic intervention in neurological disorders and the fundamental mechanisms of neurological diseases including Amyotrophic Lateral Sclerosis, Huntington's Disease, Alzheimer�s Disease, Ischemic Stroke and Neonatal Brain Injury.

Publications
Scientific Activities

Parameet KumarPhD

Postdoctoral Fellow
Department of Anatomy, Physiology and Genetics
University of the Health Sciences
Address:USA
Biography

I have completed Ph.D in Biotechnology from All India Institute of Medical Science, New Delhi, India in 2010. My master is from Indian Institute of technology Roorkee, India. After finishing Ph.D, I move to USA  & joined Mount Sinai School of medicine New York as postdoctoral fellow & later moved to Johns Hopkins University Baltimore, where I worked from 2011-2014 & developed a penchant for cystic fibrosis. At present I am working in Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD. My Research focus is on diagnostic & therapeutic implications of microRNAs in cystic fibrosis.

Research Interests

I am working on potential novel therapeutics based on various RNA-based platforms that are effective & have low toxicity to various genetic disorders. My research interest mainly focused on cystic fibrosis. Cystic Fibrosis (CF) is an common autosomal recessive genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The most common mutation is ?F508.  This mutation is associated with failure of mutant CFTR to traffic to the plasma membrane. The consequence of this trafficking failure is loss of a cAMP-activated chloride channel, and activation of massive pro-inflammatory signaling by expression of IL-8 and other cytokines and chemokines. Functional rescue of the [?F508] trafficking defect can be achieved, by low temperature or by small molecules.  My approach is based on non-coding RNAs, to look and analyze if specific microRNAs modulation can reduce pro-inflammatory IL-8 signaling in ?F508 CFTR cells, and mediate correction of the trafficking defect.

Publications
Scientific Activities

Yusuke ShiozawaPhD

Research Investigator
Department of Periodontics & Oral Medicine
University of Michigan School of Dentistry
Address:USA
Biography

Dr. Shiozawa received his MD in 2000 from the Juntendo University School of Medicine and served there as a Pediatrician focused in hematology/oncology. In 2006 he completed his Ph.D. studies and received a fellowship in pediatric oncology. In late 2006, he joined the laboratory of Dr. Russell S. Taichman at the University of Michigan as a post-doctoral fellow, and has continued in the lab as a Research Scientist since 2010. He was an awardee of the Prostate Cancer Physician Research Training Award from the Department of Defense and is now an awardee of a Young Investigator Award from the Prostate Cancer Foundation.

Research Interests

Our research focus is in establishing the parallels between hematopoietic stem cell homing to bone marrow and prostate cancer bone metastasis. Our current work is to determine whether metastatic cells from solid tumors compete with hematopoietic stem cellsfor the occupancy of the hematopoietic stem cell niche in bone marrow, and to identify factors that regulate prostate cancer dormancy in the niche.

Publications
Scientific Activities

Pedro A. JosePhD

Professor
Departments of Medicine and Physiology
University of Maryland School of Medicine
Address:USA
Biography

Pedro A. Jose, MD, PhD is Professor of Medicine and Physiology, University of Maryland School of Medicine, and Adjunct Professor of Biochemistry and Molecular & Cellular Biology, Georgetown University School of Medicine. Dr. Jose received his MD degree, magna cum laude, meritissimus, from the University of Santo Tomas, Philippines, placed first in the Philippine National Board Examinations, and received his PhD degree in Physiology (dissertation defended with distinction) from Georgetown University. The mission of the laboratory is to study the role of dopamine and adrenergic receptor subtypes and dopamine regulatory genes (e.g., G protein-coupled receptor kinase 4 [GRK4], sorting nexins, gastrin) on sodium transport in specific nephron segments and their roles in the pathogenesis of genetic hypertension and metabolic syndrome in humans and animal models of these diseases. Dr. Jose has published on hypertension-related research since 1987 and on salt-sensitive hypertension since 1993. He studies the pathogenesis of hypertension, including the role of genetics in humans, rats, and mice, in vitro and in vivo, using, molecular and cell biological methods, including gene silencing, gene rescue (e.g., AAV vectors), confocal microscopy and biophysical imaging and integrated physiology in animals and humans. Dr. Jose is a recognized expert on the role of dopamine receptors in the regulation of renal function, epithelial sodium transport, vascular function, and blood pressure.  He has also contributed novel and important information on signal transduction and cellular trafficking of dopamine receptors, including the D1-like (D1R and D5R) dopamine receptors.  He is a co-author of the seminal article that described for the first time the deletion of Drd1, the mouse D1R gene (261 citations). Dr. Jose is also a co-author of articles that described for the first time the deletion of Drd5, the mouse D5R gene (84 citations), deletion of the insulin receptor gene (325 citations), and cloning of the serotonin receptor subtype, HTR7 (414 citations). His publications (>340) are cited more than 7,800 times, with 41 cited more than 50 times, 17 of which are cited more than 100 times.  Four are covers of scientific journals and six are the subject of editorial commentaries.  Dr. Jose is experienced in directing and administering research projects including R01s and P01s - multi-center grants (e.g., R01DK039308); he has been a project director in three PPGs (P01DK052612, P01HL0749406, P01HL068686), two of which continue to be active (P01HL074940, P01HL068686). He has one active R01 grant (R01DK039308) and one R37 grant (R37HL023081). Dr. Jose has mentored 41 post graduate fellows, 9 PhD students, 2 MS students, 10 college students, and 6 high school students.  Dr. Jose has held several executive positions in academe and industry and chaired several NIH Study Sections. He was awarded a US patent on G protein-related kinase mutants in essential hypertension (US Patent Number 6,660,474) in 2003 that is recognized in Europe, Australia, and Japan. He has a provisional patent on “Compositions and Methods for Identifying and Diagnosing Salt Sensitivity of Blood Pressure” US Provisional Patent Application Serial No. 61,636,576, filed 04/20/2012.  His research has been recognized by several awards, including the 2007 Ernest H. Starling Lecturer, Water and Electrolyte Homeostasis Section, American Physiological Society, 2003 Lewis K. Dahl Memorial Lecturer (Council for High Blood Pressure Research American Heart Association), and an NIH MERIT Award (7R37HL023081-35). Deciphering the role of variations of the GRK4 gene in the causation of human essential hypertension was the second advance and discovery cited by the Director of the National Heart, Lung, and Blood Institute for its FY 2004 Budget Justification to the US Congress.

Research Interests

Renal physiology
Renal sodium transport
Hypertension
Including genetics
Pharmacogenetics of hypertension
Salt sensitivity

Publications
Scientific Activities

Pan TongPhD

Research statistical analysis
Division of Quantitative Sciences - Unit 1410
University of Texas MD Anderson Cancer Center
Address:China
Biography

Pan Tong received his B.E. degree in Bioinformatics from Huazhong University of Science and Technology, Wuhan, China in 2008 and his Ph.D from UT Health Science Center and UT MD Anderson Cancer Center in 1013. During his Ph.D training, he has developed several tools for data integration with genomics data. He now works as a research statistical analysis at UT MD Anderson Cancer Center focusing on biomarker discovery and individualized cancer therapy.

Research Interests

Biomarker discovery
Genomics
Statistical computing
Next Generation Sequencing analysis
Data mining

Publications
Scientific Activities

Raghunath ChattereePhD

Assistant Professor
Human Genetics Unit
Indian Statistical Institute
Address:India
Biography

Dr. Raghunath Chatterjee has completed his PhD from CSIR-Indian Institute of Chemical Biology, Kolkata, India in 2008. He did his post doctoral research at the National Cancer Institute, National Institutes of Health, USA. His work mainly involved epigenetics and gene regulation. After completion of his post doctoral work, he started his career as an Assistant Professor at the Human Genetics Unit of Indian Statistical Institute, Kolkata, India.

Research Interests

Genetics
Epigenetics
Gene regulation

Publications
Scientific Activities

Apostolos ZaravinosPhD

Apostolos Zaravinos,Postdoctoral Researcher
Division of Clinical Immunology & Transfusion Medi
Karolinska Institute
Address:Sweden
Biography

Dr Zaravinos is currently working as senior post-doctoral researcher in the Department of Laboratory Medicine of the KarolinskaInstitutet, in Sweden. He received his BSc from the Department of Biology of the University of Crete in 2004 and his PhD in Medicine from the same University, in 2008. He worked as an honorary Research Scientist at the Harris Birthright Research Center for Fetal Medicine, at King’s College Hospital (London, UK) between 2008-2009, before moving to Nicosia, Cyprus to carry out his postdoc at the Molecular Medicine Research Center (MMRC) at the Department of Biological Sciences of the University of Cyprus. He has authored in more than 55 peer-reviewed scientific publications in international journals and book chapters and is currently on the Editorial Board of several scientific Journals. He has participated as co- or principal investigator in several research studies, as well as in proposal submissions for research funding.

Research Interests

Evaluation of deregulated genes in various human malignancies, including those of breast, bladder and kidney, as well as on the implication of microRNAs in them. Application of genomic and transcriptomic analyses to cancer, with the goal being to define the alteration or accumulation of alterations that lead to disease phenotype, identifying novel biomarkers for the early detection and classification of disease severity and prognosis, and elucidation of targets for therapeutic and preventional intervention. My current major interests include the discovery of therapeutic targets in B cell lymphoma by next generation, high-throughput sequencing technologies.

Publications
Scientific Activities

Svetlana VojvodicPhD

Associate Professor
Department for laboratory diagnostics
Institute for Blood Transfusion of Vojvodina
Address:Serbia
Biography

Svetlana Vojvodic MD.PhD. was born in Novi Sad, on 30th September 1961. She graduated from high medical school in 1979. and and graduated in Medical Faculty at the University of Novi Sad in march of 1987. She is the full-time employed in the Department of Blood Transfusion of Vojvodina in Novi Sad from 10th February 1992. She became the transfusion medicine specialist on 31st October 1996 and since then, her professional and creative work developed in the field of HLA typing, immunohematology and transplantation medicine. 
    Postgraduate Studies started in 1997/98, at the Faculty of Medicine in Novi Sad, a thesis entitled: "MNSs blood group system in the population of South Backa ", defended on 30th June 1999. Specialization in hematology gained on 15th February 2001. PhD thesis entitled: "HLA system and allogeneic hematopoietic stem cell transplantation in leukemia and myelodysplactic syndrome", defended on 1st July 2003. During the 2004. she gained the title of Primarius. 

Research Interests

Immunohematology
Immunogenetics
Transplantation immunology
Transfusion medicine
Population genetic studies
Disease association studies

Publications
Scientific Activities

David Romero AlvarezPhD

Geneticist


Address:UK
Biography

Through my academic career I have developed a fascination for research. My interest in this path started during my BSc in Th eUniversity of Leedsand grew further during my BBSRC funded summer studentship, my industrial placement in Johnson and Johnson R&D and continued to evolve during my PhD. As a geneticist my research interests are vast as they lie on the systems that control gene expression and regulation; more specifically at the molecular biology level. I am attracted to the mechanisms by which RNA is processed, turned over, and modified in order to allow for translation to follow closely at the level of transcription. During my PhD I have done whole transcriptome analysis of the E. coli primary and secondary transcriptomes which has advanced my abilities in deep RNA-seq and data analysis significantly. It also gave me a first line insight to the complexity of gene regulation at the RNA level. This has further stimulated my interest in various fields which extend into higher organisms and range from the expression of leaderless mRNA by specialized ribosomes to sRNAs, RNAi and epigenetics.

Research Interests

Various fields which extend into higher organisms and range from the expression of leaderless mRNA by specialized ribosomes to sRNAs, RNAi and epigenetics. Vast as they lie on the systems that control gene expression and regulation

Publications
Scientific Activities

Syed Muhammad ShahidPhD

Assistant Professor
Genetic Engineering
University of Karachi
Address:Pakistan
Biography

Syed M. Shahid, male, has received Ph. D. in medical biochemistry from Department of Biochemistry, University of Karachi, Karachi, Pakistan in the year 2007-08. Earlier he received MSc in Biotechnology from the same university. Since then he is affiliated with University of Karachi, first with the Department of Biotechnology and Biochemistry, as junior lecturer and then with Dr. A. Q. Khan Institute of Biotechnology & Genetic Engineering (KIBGE), as Assistant Professor. He is currently heading the medical biotechnology section of the institute and supervising a group of MS/Ph.D. students working on various genes which are thought to be linked with the development and progression of diabetes and its complications, such as hypertension and nephropathy. He has published a number of papers describing biochemical and genetic aspects of development of diabetic complications in Pakistani population in international and national periodicals. He has also presented his research at many international scientific events. Dr. Shahid is currently working as Editor, Pakistan Journal of Biochemistry & Molecular Biology, and associated with a number of national and international journals as reviewer.

Research Interests
Publications
Scientific Activities

Jagan Mohan RaoPhD


Research scientist at Palamur Biosciences private

Address:India
Biography

P. Jagan mohan Rao, I was received my master’s degree in Microbiology from Andhra university, Visakhapatnam, Andhra Pradesh, India, in 2006 and I was started my Research carrier as a Junior research fellow at Division of Molecular Nematology, IARI, New Delhi. In 2007, I was moved to International Institute of Biotechnology and Toxicology (IIBAT), joined as a Scientist-II at department of Genetic toxicology and later I was registered my Ph. D in Andhra University, Visakhapatnam. I was done my research work on “Detection of Molecular Gene biomarkers and it’s regulation by miRNA’s in Human Papillary Thyroid carcinoma samples’’. Simultaneously, I was extended my Research work towards in-vitro and In-vivo toxicology studies on animals and I was obtained my PhD degree in 2013. Currently I’m working as a Research scientist at Palamur Biosciences private limited, Mahabubnagar, Telangana, India. The focus of my current research is mainly to find out the circulating miRNA’s for various Human carcinomas to diagnose the disease in early stages and also to identify unknown molecular pathways by conducting in-vitro and in-vivo studies.

Research Interests

Biomarker Discovery
Cancer biology
Clinical biomarkers
Genetics & Cellular and molecular mechanisms

Publications
Scientific Activities

Vikas SharmaPhD

Assistant Professor
Department of Biotechnology
University College of Science
Address:India
Biography

Dr. Vikas Sharma received his PhD in Genetics from Osmania University, India. During his doctoral studies he worked on the Cytogenetic, Biochemical, Molecular aspects of abnormal sex differentiation in humans. He is currently working as Assistant professor. He was associated with organisations like Institute of Genetics and Centre for Cellular and Molecular Biology. He has published research papers in the area of Human Cytogenetics and Molecular Biology of disorders of sex development. He has done extensive work in Cytogenetics aspect of cancer and congenital anomalies.

Research Interests

Cytogenetic studies of genetic disorders
Inborn errors of metabolism
Molecular etiology of genital anomalies
Disorders of sex development
Genetic engineering
Medical Biotechnology
Different aspects of cancer research
Cell proliferation
Motility
Adhesion
Apoptosis
Gene regulation
Signal transduction pathways

Publications
Scientific Activities

Klaus Palme PhD

Institute of Biology II / Faculty of Biology
Freiburg Institute for Advanced Science - FRIAS

Address:Germany
Biography

In 1998 Klaus Palme isolated and characterized the first plant hormone receptor gene. Later in 1998 with the discovery and functional analysis of the PIN gene family, Prof. Palme made a globally acknowledged breakthrough which has fuelled the analysis of this important plant process for many years and by numerous followers around the world. He opened an important, new field in plant biology by isolating and functionally characterizing the first genes encoding auxin transport proteins. Since then he is among the world's top scientists in plant hormone biology and cell signaling. He is heading a reference laboratory for plant physiology and instrumentation/technology development.
Due to his ability to establish new interdisciplinary approaches, Klaus Palme became a valuable member in national and international research consortia, particularly in development of innovative methods for cell biological analysis. His publications are highly cited illustrating the high quality and attractiveness. His work is acknowledged by several prizes, documented by the choice in international scientific organizations, and through selection of grantees by the prestigious Humboldt foundation. He has been and is a plenary speaker at and organizer of major national and international conferences in the field of biological signaling, imaging and systems biology. He has demonstrated his leadership many times by organizing international conferences, by providing professional service as Head of the interdisciplinary Max-Delbrück-Laboratorium (Cologne), headed a DFG funded Graduate School Sciences, initiated and coordinated national and international academic as well as industrial research consortia and acts in editorial and advisory boards of learned journals. He is currently heading a research consortium on “Quantitative 3D and 4D cell analysis in living organisms”. He is fellow of the Freiburg Institute for Advanced Studies, the international research college of the University. He serves as a member of the Board of Directors of the Freiburg Center for Systems Biology (ZBSA) and as Director of the Institute of Biology at the University of Freiburg. In summary, Klaus Palme has an excellent track record in excellent research and collaboration with both academia and industry as reflected by international recognitions and prizes.

Research Interests
Publications
Scientific Activities

Ximiao HePhD

Postdoctoral Visiting Fellow & Research Fellow
Gene Regulation Section
National Cancer Institute
Address:USA
Biography

Dr. Ximiao He earned his B.S. degree at Tongji Medical College, Huazhong University of Science and Technology in China in 2002, and his Ph.D. degree in genomics at Beijing Institute of Genomics (BIG), Chinese Academy of Sciences (CAS) in 2009.  The training in genomics and bioinformatics has contributed to his development of several publicly available genomic databases and database on DNA methylation and cancers. He went to National Cancer Institute, NIH in 2009 as a post-doctoral fellow, where he focused on the study of the effects of nucleosome occupancy and methylation on gene regulation.He has coauthored 16 highly cited scientific papers so far. His research focuses on DNA methylation, CpG islands and cancer, alternative splicing in disease and development, evolution of new genes and comparative genomics, as well as the development of tools and web services for analysis of genomic and epigenomic data.

Research Interests

DNA methylation in cell differentiation and cancer
Effects of nucleosome occupancy and methylation on gene regulation
Alternative splicing in disease and development
Evolution of new genes and comparative genomics
Tools and web services for analysis of genomic/epigenomic data

Publications
Scientific Activities

Michela Alessandra DentiPhD

Assistant Professor
Molecular Biology
University of Trento
Address:Italy
Biography

Dr. Michela Alessandra Denti obtained her PhD in Biological Sciences in 1997 from the Scuola Normale Superiore di Pisa, Italy, working on the in vivo application, the intracellular localisation and the association to RNA-binding proteins of a newt hammerhead ribozyme.
She then went on to do postdoctoral research at the Institute of Molecular Biology and Biotechnology, Heraklion, Greece, under the guidance of Prof. Martin Tabler and Prof. Mina Tsagris, studying plant RNA pathogens, their interaction with RNA-binding proteins and their involvement in post-transcriptional gene signaling (1998-2001).
During a second postdoctoral research period in Prof. Irene Bozzoni’s laboratory at the Department of Genetics and Molecular Biology, “Sapienza” University of Rome, Italy (2002-2007) she was involved in the development of the antisense-U1snRNA mediated exon skipping therapy for Duchenne muscular dystrophy and in the development and application of DNA vectors for RNA interference. Since 2008 she is Principal Investigator of the Laboratory of RNA Biology and Biotechnology and Assistant Professor of Molecular Biology at the Centre for Integrative Biology of The University of Trento, Italy. Her laboratory has two main research interests: modulation of RNA splicing as a cure for inherited diseases and microRNAs as biomarkers of cancer, cardiac and neurodegenerative diseases.

Research Interests

MicroRNAs
Antisense-mediated exon skipping therapy
RNA interference
Frontotemporal dementia
Neurodegenerative diseases
Retinal dystrophies

Publications
Scientific Activities

Nour FouzPhD

Experienced in research laboratory
conducting independent experiments and projects

Address:Jeddah
Biography
Research Interests
Publications
Scientific Activities

Frank M. YouPhD

Research scientist
Bioinformatics at Cereal Research Centre
Agriculture and Agri-Food
Address:Canada
Biography

Dr. Frank You is a research scientist in bioinformatics at Cereal Research Centre, Agriculture and Agri-Food Canada (AAFC), Canada. He earned Ph.D in plant genetics and breeding with statistical genetics and a BS degree in agronomy and a BS degree in computer science. Dr. You has the expertise in computational biology and bioinformatics, statistical genetics and plant genetics and breeding. His research interests include plant comparative and statistical genomics, quantitative genetics, genome assembly and annotation of complex genomes, gene expression and microarray data analysis, physical mapping and data analysis, high-throughput molecular marker design and development, bioinformatics software development.Dr. You has contributed more than 70 peer-reviewed papers in scientific journals, many of which are very top in the field, such as Nature and PNAS.

Research Interests

High-throughput molecular marker design and development for improving research and breeding efficiency.
High-throughput single nucleotide polymorphism discovery strategies using next-generation sequencing.
Data mining strategy and methodology
Software design and development of data mining based on next-generation sequencing 
Whole genome sequencing strategies and genome assembly of complex genomes.
Comparative genomics and gene evolution.
Quantitative genetics analysis of economically important complex traits.
Gene expression analysis.

Publications
Scientific Activities

Qizhao WangPhD

Assistant scientist
School of medicine
Temple university
Address:Philaldelphia, PA
Biography

My research as a molecular biologist currently centers about the development and use of adeno-associated virus(AAV) vectors for gene therapy of genetic diseases and cancers. AAV-based gene therapeutics has been extensively studied in different clinical applications, demonstrating some impressive efficiency and safety profiles. One of my interest is to develop novel strategies, such as RNAi, to enhance the packaging efficiency and transduction efficiency of AAV vectors. In order to achieve this aim, it is critically important for us to study interactions of those vectors with endogenous AAVs, host genome and host innate defense systems and potential consequences of such interactions. Besides the host-virus interactions, it is also important to study the effect of cis elements of AAV genome on AAV packaging. Also, I’m interest in exploring AAV vectors for delivery of denovo synthesized biological miRNA antagonists or over express microRNAs to elucidate micro RNA functions in diseases.

Research Interests

Develop novel strategies such as RNAi to enhance the packaging efficiency Transduction efficiency of AAV vectors

Publications
Scientific Activities

Weimin QiuPhD

Research Assistant Professor in KMEB
Department of Endocrinology
Odense University Hospital
Address:Denmark
Biography

Dr. Weimin Qiu completed his Ph.D in medical genetics at the West China Hospital of Sichuan University in China. He started postdoctoral research and now is assistant professor at the Department of Endocrinology, Odense University Hospital in Denmark. His research focus on the controlling the differentiation of mesenchymal stem cell.

Research Interests

Signaling pathways in regulating bone formation.
Telomerase function in bone homeostasis.
Kinase involved in osteoblast differentiation.

Publications
Scientific Activities

Yupeng WangPhD

Research Fellow
National Center for Biotechnology Information (NCB
National Institutes of Health (NIH)
Address:USA
Biography

Dr. Yupeng Wang completed his Ph.D. in bioinformatics at University of Georgia in 2011. Then, he worked as a bioinformatician at Cornell University. Currently he is a Research Fellow at NCBI, NIH. His research focuses on bioinformatics, computational genomics, association studies, high performance computing, big data analysis, databases and machine learning models

Research Interests

Genomics and bioinformatics
Analysis of plant genomes
Algorithms for detecting genomic rearrangements in tumors
Computational models of gene expression regulation by enhancers
Computational models for complex genetic diseases
Regulatory landscape of the human genome by analyzing big data

Publications
Scientific Activities

Armin SchmittPhD

Assistant Professor
Advanced Statistics
University of Bozen
Address:Italy
Biography

Dr. Armin Schmitt received his PhD in biophysics from the Humboldt-Universtät zu Berlin(Germany). After postdoctoral positions at the Max Planck-Institute of Molecular Geneticsin Berlin and at the Weizmann-Institute in Rehovot (Israel) he worked in the biotechnologyindustry as bioinformatics scientist. He is currently assistant professor at the  Free University of Bozen/Bolzano (Italy) where he teaches statistics. His research is focused on bioinformatics and genomics.

Research Interests

Bioinformatics
Genomics

Publications
Scientific Activities

Abdou ElsharawyPhD

Senior postdoctor Researcher
Department of Science
University of Kiel
Address:Germany
Biography

Dr. Elsharawy studied Biochemistry at Faculty of Sciences, Mansoura University in Egypt. After finishing his M.Sc. in Biochemistry (Cytogenetics), he rewarded a governmental scholarship to study abroad. He received his PhD in cell biology (Genetics and Immunology), with grade 1.0, Faculty of Mathematics and Natural Sciences, Christian Albrechts University (CAU) of Kiel, Kiel, Germany. Currently he is a senior postdoc researcher at Institute of Clinical molecular Biology, Center of Molecular Sciences (CMB), University of Kiel (CAU), Germany. His main scientific interests are the development of advanced molecular and sequencing strategies and integration of multiple types of data in a try to comprehensively understand complex biological paradigms. He started in his PhD to address part of this big challenge by systematically evaluating the effects of genomic variations on pre-mRNA splicing. Thereafter, he has been working on the establishment of high-throughput NGS approaches, development of novel bioinformatics solutions, and on multicenter miRNA studies of human diseases and longevity. His current research focuses on the employment of the advanced analytical techniques and exploration of novel tools to uncover the (genomic, proteomic and lipidomic) contents of and roles played by circulating exosomes (extracellular microvesicles) as molecular cargo-nanocarriers in chronic inflammatory and cancer diseases.

Research Interests

Complex genetic disorders, such as inflammatory bowel diseases and cancer
Disease-associated mutations and miRNAs
High- throughput targeted, exome, and genome next-generation sequencing
Molecular diagnostics
Extracellular vesicles (or exosomes)

Publications

Andreas Keller, Petra Leidinger, Britta Vogel, Christina Backes, Abdou ElSharawy, Valentina Galata, Sabine Müller, Sabine Marquart, Michael G. Schrauder, Reiner Strick, Andrea Bauer, Jörg Wischhusen, Markus Beier, Jochen Kohlhaas, Hugo A. Katus, Jörg Hoheisel, Andre Franke, Benjamin Meder, Eckart Meese. miRNAs can be generally associated with human pathologies as exemplified for miR-144*. BMC Med. 2014 Dec 3;12(1):224.

 

Forster, Michael*; Forster, Peter*; ElSharawy, Abdou*; Hemmrich, Georg; Kreck, Benjamin; Wittig, Michael; Thomsen, Ingo; Stade, Bjoern; Barann, Matthias; Ellinghaus, David; Petersen, Britt-Sabina; May, Sandra; Melum, Espen; Schilhabel, Markus; Keller, Andreas; Schreiber, Stefan; Rosenstiel, Philip; Franke, Andre: From next-generation sequencing alignments to accurate comparison and validation of single nucleotide variants: the pibase software. Nucleic Acids Res., 2013 41:e16.* Joint First Authors.

 

Abdou ElSharawy, Andreas Keller, Friederike Flachsbart, Anke Wendschlag, Gunnar Jacobs, Nathalie Kefer, Thomas Brefort, Petra Leidinger, Christina Backes, Eckart Meese, Stefan Schreiber, Philip Rosenstiel, Andre Franke, Almut Nebel:  Genome-wide miRNA signatures of human longevity. Aging Cell, 2012 Apr 26. doi: 10.1111/j.1474-9726.2012.00824.x.

 

Abdou ElSharawy, Michael Forster, Nadine Schracke, Andreas Keller, Ingo Thomsen, Britt-Sabina Petersen, Björn Stade, Peer Stähler, Stefan Schreiber, Philip Rosenstiel and Andre Franke: Improving mapping and SNP-calling performance in multiplexed targeted next-generation sequencing. BMC Genomics, 2012 Aug 22;13(1):417. DOI: 10.1186/1471-2164-13-417.

 

Abdou ElSharawy, Jason Warner, Jeff Olson, Michael Forster, Markus B. Schilhabel, Darren Link, Stefan Rose-John, Stefan Schreiber, Philip Rosenstiel, James Brayer and Andre Franke: Accurate Variant Detection across Non-amplified and Whole Genome Amplified DNA Using Targeted Next Generation Sequencing. BMC Genomics, 2012 Sep 20;13:500. doi: 10.1186/1471-2164-13-500.

 

Keller A*, Leidinger P*, Bauer A, Elsharawy A, Haas J, Backes C, Wendschlag A, Giese N, Tjaden C, Ott K, Werner J, Hackert T, Ruprecht K, Huwer H, Huebers J, Jacobs G, Rosenstiel P, Dommisch H, Schaefer A, Müller-Quernheim J, Wullich B, Keck B, Graf N, Reichrath J, Vogel B, Nebel A, Jager SU, Staehler P, Amarantos I, Boisguerin V, Staehler C, Beier M, Scheffler M, Büchler MW, Wischhusen J, Haeusler SF, Dietl J, Hofmann S, Lenhof HP, Schreiber S, Katus HA, Rottbauer W, Meder B, Hoheisel JD, Franke A, Meese E. (2011) Toward the blood-borne miRNome of human diseases. Nat Methods.  2011, 8(10):841-3. * Shared First Authors.

 

Ellinghaus E, Stanulla M, Richter G, Ellinghaus D, Te Kronnie G, Cario G, Cazzaniga G, Horstmann M, Panzer Grümayer R, Cavé H, Trka J, Cinek O, Teigler-Schlegel A, Elsharawy A, Häsler R, Nebel A, Meissner B, Bartram T, Lescai F, Franceschi C, Giordan M, Nürnberg P, Heinzow B, Zimmermann M, Schreiber S, Schrappe M, Franke A: Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Leukemia. 2011, Nov 11. doi: 10.1038/leu.2011.302.

 

Mertes F, Elsharawy A, Sauer S, van Helvoort JM, van der Zaag PJ, Franke A, Nilsson M, Lehrach H, Brookes AJ (2011). Targeted enrichment of genomic DNA regions for next-generation sequencing. Brief Funct Genomics, 2011, Nov;10(6):374-86. Epub 2011 Nov 26.

 

Johannes R. Hov; Verena Keitel; Jon K. Laerdahl; Lina Spomer; Eva Ellinghaus; Abdou ElSharawy; Espen Melum; Kirsten M. Boberg; Thomas Manke; Tobias Balschun; Christoph Schramm; Annika Bergquist; Tobias Weismüller; Daniel Gotthardt; Christian Rust; Liesbet Henckaerts; Clive M. Onnie; Rinse K. Weersma; Martina Sterneck; Andreas Teufel; Heiko Runz; Adolf Stiehl; Cyriel Y. Ponsioen; Cisca Wijmenga; Morten H. Vatn; for the IBSEN study group; Pieter Stokkers; Severine Vermeire; Christopher G. Mathew; Benedicte A. Lie; Ulrich Beuers; Michael P. Manns; Stefan Schreiber, Erik Schrumpf; Dieter Häussinger; Andre Franke; Tom H. Karlsen: Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. PLoS One, 2010, Aug 25;5(8). pii: e12403.

 

ElSharawy A, Hundrieser B, Brosch M, Wittig M, Huse K, Platzer M, Becker A, Simon M, Rosenstiel P, Schreiber S, Krawczak M and Hampe J: Systematic Evaluation of the Effect of Common SNPs on Pre-mRNA Splicing. Hum Mutat. 2009, 30(4):625-32.

 

Clemens Schafmayer, Stephan Buch, Henry Völzke, Witigo von Schönfels, Jan Hendrik Egberts, Bodo Schniewind, Mario Brosch, Andreas Ruether, Andre Franke, Micaela Mathiak, Bence Sipos, Tobias Henopp, Jasmin Catalcali, Stephan Hellmig, Abdou ElSharawy, Alexander Katalinic, Markus M Lerch, Ulrich John, Ulrich R. Fölsch, Fred Fändrich, Holger Kalthoff, Stefan Schreiber, Michael Krawczak, Jürgen Tepel, Jochen Hampe: Investigation of the colorectal cancer susceptibility region on chromosome 8q24.21 in a large German case-control sample. Int J Cancer., 2009 1;124(1):75-80.

 

Buch S, Schafmayer C, Volzke H, Becker C, Franke A, von Eller-Eberstein H, Kluck C, Bassmann I, Brosch M, Lammert F, Miquel JF, Nervi F, Wittig M, Rosskopf D, Timm B, Holl C, Seeger M, Elsharawy A, Lu T, Egberts J, Fandrich F, Folsch UR, Krawczak M, Schreiber S, Nurnberg P, Tepel J, Hampe J: A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease. Nat Genet. 2007, 39(8):995-999.

 

Clemens Schafmayer, Henry Völzke, Stephan Buch, Jan Egberts, Annika Spille, Huberta von Eberstein, Andre Franke, Markus Seeger, Sebastian Hinz, Abdou ElSharawy, Dieter Rosskopf, Mario Brosch, Michael Krawczak, Ulrich R. Foelsch, Anton Schafmayer, Frank Lammert, Stefan Schreiber, Fred Faendrich, Jochen Hampe, JuergenTepel: Investigation of the Lith6 candidate genes APOBEC1 and PPARG in human gallstone disease. Liver International, 2007, 27 (7): 910-919.

 

Franke A, Hampe J, Rosenstiel P, Becker C, Wagner F, Hasler R, Little RD, Huse K, Ruether A, Balschun T, Wittig M, Elsharawy A, Mayr G, Albrecht M, Prescott NJ, Onnie CM, Fournier H, Keith T, Radelof U, Platzer M, Mathew CG, Stoll M, Krawczak M, Nurnberg P, Schreiber S: Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene. PLoS ONE., 2007,  2:e691.

 

Schafmayer C, Buch S, Egberts JH, Franke A, Brosch M, El Sharawy A, Conring M, Koschnick M, Schwiedernoch S, Katalinic A, Kremer B, Folsch UR, Krawczak M, Fandrich F, Schreiber S, Tepel J, Hampe J (2007). Genetic investigation of DNA-repair pathway genes PMS2, MLH1, MSH2, MSH6, MUTYH, OGG1 and MTH1 in sporadic colon cancer. Int J Cancer, 2007 121(3): 555-8.

 

ElSharawy A, Manaster C, Teuber M, Rosenstiel P, Kwiatkowski R, Huse K, Platzer M, Becker A, Nurnberg P, Schreiber S and Hampe J: SNPSplicer: systematic analysis of SNP-dependent splicing in genotyped cDNAs. Hum Mutat, 2006 27(11): 1129-34.

 

Karawya EM; Abdel-Malak CA; Settin AA and ElSharaway A: Chromosomal anomalies in mentally handicapped Children from Damietta Governorate. The Egyptian Journal of Medical Sciences; 2002, 21(1) June: 237-246.

Scientific Activities

BURAK KARACAÖRENPhD

Assistant Professor
Department of Animal Science
University of Akdeniz
Address:TURKEY
Biography

Burak Karacaören received his B.Sc. degree in Animal Science (Faculty of Agriculture) and M.Sc. in Biometry and Genetics (Institute of Natural Sciences) from Akdeniz University, Antalya, Turkey in 1999 and 2001 respectively. He spent 6 months in As, Agricultural University of Norway, Norway about animal production and statistics. He received his Dr.Sc.degree in Statistical Animal Genetics Group (Institute of Animal Sciences) from Swiss Federal Institute of Technology Zurich (ETH Zurich), Switzerland at 2006. As a part of his doctorate studies he spent 2 months in INRA Paris, France. He was a post doctoral researcher at the Roslin Institute, University of Edinburgh, Scotland, UK in Genetics and Genomics department and at the Laurentian Forestry Institute, University of Laval, Quebec, Canada in forestry genomics in 2008-2010 and 2010-2011 respectively. Currently he is an assistant professor in Biometry and Genetics Section, Department of Animal Science at Akdeniz University, Turkey.

Research Interests

Statistical methods applied to genetics
Genomics and animal breeding

Publications

Suzanne J Rowe, Burak Karacaören, Dirk-Jan De Koning, Boris Lukic, Nicola Hastings-Clark, Ingela Velander, Chris S Haley, Alan L Archibald (2014) Analysis of the genetics of boar taint reveals both single SNPs and regional effects. BMC Genomics 15(1) 424

Karacaören, B (2014) Admixture Mapping of Growth Related Traits in F2 Mice Dataset Using Ancestry Informative Markers. J Bioinform Comput Biol.

Karacaören, B (2014) Empirical comparison of association and admixture mapping for     body weight using F2 mice data set, 57: 1-6. Archiv Tier Zucht.

Karacaören, B. (2013) Investigations on pleiotropy and genome wide association analyses by random effects using QTL-MAS 2010 dataset, 60: 209-212. Ankara Uni. Vet. Fak. Derg.

Karacaören, B ve F?rat, MZ (2012) Genetik ?lerlemelerin Hesaplanmas?nda Kullan?lan

Yöntemlerin Kar??la?t?r?lmas?, 59: 115-120. Ankara Uni. Vet. Fak. Derg.

Karacaören, B., L.L.G. Janss and H. N. Kadarmideen. (2012) Predicting breeding values in animals by kalman filter: application to body condition scores in dairy cattle. 18(4) 627-632. Kafkas Uni. Vet. Fak. Derg.

Karacaören, B. (2012) Some observations for discordant sib pair design using QTLMAS2010 simulated data set. 18(5):857-860 Kafkas Uni. Vet. Fak. Derg.

Karacaören, B., and H.N. Kadarmideen (2008). Principal Component and Clustering Analyses of Functional Traits in Dairy Cattle. 2008: 32(2). Turk. J. Vet. Anim. Sci.

Karacaören, B., F. Jaffrézic, and H.N. Kadarmideen (2006). Genetic Parameters of Functional Traits in Dairy Cattle from Daily Random Regression Models. 2006. 89: 791-798. J. Dairy Sci.

Karacaören, B., H.N. Kadarmideen, and L.L.G. Janss (2006). Investigation on Major Genes for Milk Yield, Milking Speed, Dry Matter Intake, and Body Weight in Dairy Cattle. 2006. 47: 337-343.  Journal of Applied Genetics.

Scientific Activities

Pawel CieszczykPhD

Professor
Department of Physical Culture and Health Promotion
University of Szczecin
Address:Poland
Biography

My name is Pawe? Ci?szczyk and I was born on 6th June 1976 in Goleniów. In 1995 I graduated from the High School Number 1 in Goleniów. The same year I started my Physical Education studies in Gorzów Wielkopolski, at the local branch of the Physical Culture Department of the University School of Physical Education in Pozna?. After the first semester I moved to the Institute of Physical Culture at the Department of Life Sciences at the University of Szczecin. I graduated in 2000, obtaining the Master of Science degree in Physical Education. In 2002 I also obtained MSc in Computer Science and Econometrics. Since 2002 I have been working as an assistant at the Unit of Various Sports, the Department of Life Sciences at the University of Szczecin (currently the Department of Physical Culture and Health Promotion). On 7 November 2007, I obtained PhD in physical culture, based on the thesis Effectiveness of motor preparation at the early stage of training as the premise for the rationalization of the training process in sport classes specialized in team games, under the supervision of prof. Jerzy Eider. Even before writing my doctoral thesis, I had been interested in the possibility of using molecular biology for sport purposes. Together with the researchers from the Genetics Deparmennt of the Szczecin University, in 2008 I designed a research project entitled Polymorphism of selected genes in highly skilled athletes as the basis for genetic profiles used in the pre-selection of players  (the research involved the following genes: ACE, BDKRB2, NOS3, ADRA2A, ADRB1, ADRB2,  ADRB3, ACTN3, MSTN, PPARα, PGC-1, AMPD1, CK) which granted support from the Ministry of Science and Higher Education. The research was (and is) followed other research projects concerning the possibility of using the molecular biology in sport. 1. The influence of polymorphisms of selected genes (ACE, AMPD1, ATP1A2, HIF1, PPARD, NRF1, VEGF, PPARG, ACTN3, IGF1, IL5, TNF) on the character and range of post-exercise adaptation response. 2. Polymorphism of selected genes (HIF1, MCT1, EPAS1, NFATC4, PPARD, PPP3R1, TFAM, UCP2, UCP3, VEGFA, PPARG, IL-6) in highly skilled athletes as the basis for genetic profiles used in preliminary selection of athletes3. The relationship between the polymorphisms of selected genes encoding collagen proteins and the risk of Anterior Cruciate Ligament injury My scientific achievements include the publication of 83 papers. Seven of them are books – monographs, scripts and student books. My articles have been published in reviewed scientific journals (30 have been published in journals included in the ISI database). Since the beginning of my scientific career, I have put great emphasis on my participation in various scientific conferences (altogether 23 scientific conferences in Poland and abroad). In the realized research projects, I have cooperated with many scientific centers in Poland and abroad, i.e. Genetics Department at the University of Szczecin, Department of Clinical and Molecular Biochemistry – Pomeranian Medical University, Galen Medical Center in Bierun; Pedagogical University in Vilnius, Lithuania, Kent University w Ohio/USA, Sports Genetics Laboratory in Sankt Petersburg, Russia; Institute for Biomedical Problems of the Russian Academy of Sciences in Moscow/Russia, The Zinman College of Physical Education and Sport Sciences at the Wingate Institute in Netanya/Israel,  Universidad Europea de Madrid in Madrid, Spain; Karolinska Institutet w Stockholm, Sweden.Currently, I’m a Vice Dean of Department of Physical Culture and Health Promotion, at the University of Szczecin. I am the head of the Laboratory of Human Biology. I conduct classes for students in various subjects, including Genetics in Sport and Biostatistics and Statistics.

Research Interests

Genetics in sport

Genetics

Physiology

Biochemistry

Publications
  1. Jerzy Eider, dr hab., Krzysztof Ficek, dr n.med., Mariusz Kaczmarczyk, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, drPawe? Jan Ci?szczyk, dr hab.; Central European Journal of Biology. Endothelial Nitric Oxide Synthase G894T (rs1799983) gene polymorphism in Polish athletes. 2014, 9(3), 260-267.
  2. Nir Eynon, prof., Lauren Banting, dr, Jonathan Ruiz, dr, Pawe? Jan Ci?szczyk, dr hab. Dmitry Dyatlov, dr, Agnieszka Maciejewska-Karlowska, dr, Marek Sawczuk, dr, Vladimir Pushkarev, dr, Leonid Kulikov, dr, Evgeny Pushkarev, dr, Pedro Femia, dr, Noil Stepto, dr, David Bishop, prof., Alejandro Lucia, prof.; Journal of Science and Medicine in Sport. ACTN3 R577X polymorphism and team-sport performance: A study involving three European cohorts. 2014, 17(14), 102–106.
  3. Marek Sawczuk, dr, Agnieszka Maciejewska-Kar?owska, dr, Agata Leo?ska-Duniec, drPawe? Jan Ci?szczyk, dr hab.; Biology of Sport. Is GNB3 C825T polymorphism associated with elite status of Polish athletes?  2014, 31:21-25.
  4. Marek Sawczuk, dr, Lauren Banting ,dr, Pawe? Ci?szczyk, dr hab., Agnieszka Maciejewska-Karlowska, dr, Aleksandra Zar?bska, dr, Agata Leo?ska-Duniec, dr, Zbigniew Jastrz?bski, dr hab., David Bishop, prof., Nir Eynon, dr; Journal of Science and Medicine in Sports. MCT1 A1470T:  a novel polymorphism for sprint performance? DOI : http://dx.doi.org/10.1016/j.jsams.2013.12.008
  5. Zi-Hong He, dr, Yang Hu, dr, Yan-Chun Li, dr, Li-Jing Gong, dr, Pawel Jan Cieszczyk, dr hab., Agnieszka Maciejewska-Karlowska, dr hab., Agata Leonska-Duniec, dr,Carlos Muniesa, dr, Maria Marín-Peiro, dr, Catalina Santiago, dr, Nuria Garatachea, dr, Nir Eynon, prof., Alejandro Lucia, prof.; Scandinavian Journal of Medicine & Science in Sports. PGC-related gene variants and elite endurance athletic status in a Chinese cohort: a functional study. 2014, DOI: 10.1111/sms.12188..
  6. Chamera Tomasz, dr, Spieszny Micha?, dr hab, Klocek Tomasz, dr, Kostrzewa-Nowak Dorota, dr, Nowak Robert, dr, Lachowicz Milena, dr, Buryta Rafa?, mgr, Ci?szczyk Pawe?, dr hab.; Journal of Strength and Conditioning Research. Could biochemical liver profile help to assess metabolic response to aerobic effort in athletes? DOI: 10.1519/JSC.0000000000000398)
  7. Chamera Tomasz, dr, Spieszny Micha?, dr hab, Klocek Tomasz, dr, Kostrzewa-Nowak Dorota, dr, Nowak Robert, dr, Lachowicz Milena, dr, Buryta Rafa?, mgr, Eider Jerzy, dr hab., Moska Waldemar, dr hab., Ci?szczyk Pawe?, dr hab.; Journal of Medical Biochemistry. Post-effort changes in activity of traditional diagnostic enzymatic markers in football players’ blood. DOI: 10.2478/jomb-2014-0035).
  8. Agata Grenda, mgr, Agata Leo?ska-Duniec, drPawe? Jan Ci?szczyk, dr hab., Piotr ?mijewski, dr; Biology of Sport. BDKRB2 gene -9/+9 polymorphism and swimming performance  2014, 31:109-113.
  9. Sarath Voisin, dr, Pawe? Cieszczyk, dr hab., Vladimir Pushkarev, dr, Dmitry Dyatlov, dr, Boris Vashlyayev, dr, Vladimir Shumaylov, dr, Agnieszka Maciejewska-Karlowska, dr, Marek Sawczuk, dr, Lidia Skuza, dr, Zbigniew Jastrzebski, dr hab, Bishop David, prof., Eynon Nir, dr; BMC Genomics. Interaction between gene variants in the EPSA1 gene and their impact on elite athletic performance in two cohorts of European athletes. 2014, 15:382  doi:10.1186/1471-2164-15-382
  10. Ildus Ahmetov, prof., Vladimir Naumov, dr, Andrey Donnikov, dr, Agnieszka Maciejewska-Kar?owska, dr, Elena Kostryukova, dr, Andrey Larin, dr, Evgeniya Maykova, dr,  Dmitry Alexeev, dr, Olga Fedotovskaya, dr, Edward Generozov, dr, Zbigniew Jastrz?bski, dr hab., Piotr ?mijewski, dr, Olga Kravtsova, dr, Nickolay Kulemin, dr, Agata Leonska-Duniec, dr, Dilyara Martykanova, dr, Elena Ospanova, dr, Alexander Pavlenko, dr, Alla  Podolskaya, dr, Marek Sawczuk, dr, Farida Alimova, dr, Dmitry Trofimov, dr, Vadim Govorun, dr, Pawel Cieszczyk, dr hab.; Free Radical Research. The SOD2 gene polymorphism and muscle damage markers in elite athletes. doi: 10.3109/10715762.2014.928410
  11. Leysan Mustafina, dr, Vladimir Naumov, dr, Pawel Cieszczyk, dr hab., Daniil Popov, prof., Ekaterina Lyubaeva, dr, Elena Kostryukova, dr, Olga Fedotovskaya, dr, Anastasiya  Druzhevskaya, dr, Irina Astratenkova, dr, Andrey Glotov, dr, Dmitry Alexeev, dr, Milyausha Mustafina, dr, Emiliya Egorova, dr, Agnieszka Maciejewska-Kar?owska, dr, Andrey Larin, dr, Edward Generozov, dr, Ruslan Nurullin, dr, Zbigniew Jastrz?bski, dr hab., Nickolay Kulemin, dr, Elena Ospanova, dr, Alexander Pavlenko, dr, Marek Sawczuk, dr, Egor Akimov, dr, Anna Danilushkina, dr, Piotr ?mijewski, dr, Olga Vinogradova, dr, Vadim Govorun, dr, Ildus Ahmetov, prof.; Experimental Physiology. The AGTR2 gene polymorphism is associated with muscle fibre composition, athlete status and aerobic performance. DOI.10.1113/expphysiol.2014.079335 
  12. Kevin O’Connell, dr, Hayley Knight, dr, Krzysztof Ficek, dr, Agata Leonska-Duniec, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr, Marta Stepien-Slodkowska, dr, Deon O’Cuinneagain, dr, Willem Van Der Merwe, dr, Michael Posthumus, dr, Pawel Cieszczyk, dr hab., Malcolm Collins, prof.; European Journal of Sport Science. Interactions between collagen gene variants and risk of anterior cruciate ligament rupture. DOI http://dx.doi.org/10.1080/17461391.2014.936324.
  13. Krzysztof Ficek, dr, Marta St?pie?- S?odkowska, dr, Mariusz Kaczmarczyk, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr, Jerzy Cholewi?ski, dr, Agata Leo?ska-Duniec, dr, Aleksandra Zar?bska, dr, Pawe? Ci?szczyk, dr hab., Piotr ?mijewski, dr; Balkan Journal of Medical Genetics. Does the A9285G polymorphism in the collagen type XII alpha-1 gene associate with the risk of anterior cruciate ligament ruptures? 2014, 17 (1): 1-6, DOI: 10.2478/bjmg-2014-0022.
  14. Aleksandra Zar?bska, dr, Zbigniew Jastrz?bski, dr, Mariusz Kaczmarczyk, dr, Krzysztof Ficek, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr, Agata Leo?ska-Duniec, dr, Pawe? Król, dr, Pawe? Ci?szczyk, dr hab., Piotr ?mijewski, dr, Nir Eynon, prof.; Biology of Sport. The rs1695 (c.313A>G) polymorphism in the GSTP1 gene modulates VO2max improvements in response to aerobic dance training. 2014,31:261-266
  15. Agata Grenda, mgr, Agata Leo?ska-Duniec, dr, Mariusz Kaczmarczyk, dr, Krzysztof Ficek, dr, Pawe? Król, dr, Pawe? Ci?szczyk, dr hab., Piotr ?mijewski, dr; Journal of Human Kinetics. Genetic Variation of ACE and ACTN3 in Elite Polish Swimmers. 2014,42:127-135.
  16. Aleksandra Zarebska, dr, Zbigniew Jastrzebski, dr hab. Pawe? Ci?szczyk, dr hab., Agata Leonska-Duniec, dr, Katarzyna Kotarska,dr, Mariusz Kaczmarczyk, dr, Marek Sawczuk, dr, Agnieszka Maciejewska-Karlowska, dr hab.; PPAR Research. The Pro12Ala polymorphism of the Peroxisome Proliferator-Activated Receptor gamma gene modify the association of physical activity and body mass changes in Polish women. DOI. 10.1155/2014/373782
  17. Orysiak Joanna, dr, Sitkowski Dariusz, dr, Zmijewski Piotr, dr,  Malczewska-Lenczowska Jadwiga, dr hab., Cieszczyk Pawe?, dr hab., Zembron-Lacny Agnieszka, dr hab., Pokrywka Andrzej, dr;. Journal of Strength and Conditioning Research. Overrepresentation of the ACTN3 XX genotype in elite canoe and kayak paddlers. DOI. 10.1519/JSC.0000000000000717
  18. Kostrzewa – Nowak Dorota, dr, Nowak Robert, dr, Chamera Tomasz, dr,  Buryta Rafa?, dr, Moska Waldemar, dr hab., Cieszczyk Pawe?, dr hab.; Journal of Strength and Conditioning Research. Post-effort chances in c-reactive protein level among soccer players at the end of the training season. doi: 10.1519/JSC.0000000000000753  
  19. Marek Sawczuk, dr, Yevgeniya I. Timshina, dr, Irina V. Astratenkova, dr, Agnieszka Maciejewska-Kar?owska, dr, Agata Leo?ska-Duniec, dr, Krzysztof Ficek, dr, Leysan J. Mustafina, dr, Pawe? Ci?szczyk, dr hab., Tomasz Klocek, dr, Ildus I. Ahmetov, prof; Human Biology. The –9/+9 Polymorphism of the Bradykinin Receptor Beta 2 Gene and Athlete Status: A Study Involving Two European Cohorts.). 2013, 85(4), 743-757.
  20. Aleksandra Zar?bska, dr, Ildus Ahmetov, dr, Stanis?aw Sawczyn, dr hab., Alexandra Weiner, dr, Mariusz Kaczmarczyk, dr, Krzysztof Ficek, dr n.med., Agnieszka Maciejewska-Karlowska, dr, Marek Sawczuk, dr, Agata Leo?ska-Duniec, dr, Tomasz Klocek, dr, Elena Voronina, dr, Uljana Boyarskikh, dr, Maksim Filipenko, dr, Pawe? Jan Ci?szczyk, dr hab.; Journal of Sports Sciences. Association of the MTHFR 1298A>C (rs1801131) polymorphism with speed and strength sports in Russian and Polish athletes. (DOI:10.1080/02640414.2013.825731.
  21. Marta St?pie?-S?odkowska, dr, Krzysztof Ficek, dr n.med., Jerzy Eider, dr hab., Agata Leo?ska-Duniec, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr, Aleksandra Zar?bska, dr, Zbigniew Jastrz?bski, prof., Agata Grenda, mgr, Katarzyna Kotraska, dr, Pawe? Jan Ci?szczyk, dr hab. Biology of Sport. The +1245G/T polymorphisms in the collagen type I alpha-1 (COL1A1) gene as one of genetic marker in Anterior Cruciate Ligament injury. 2013, 30, 57-60.
  22. Jerzy Eider, dr hab., Agnieszka Maciejewska, dr, Marek Sawczuk, dr, Pawe? Jan Ci?szczyk, dr hab., Magdalenia Ostanek, dr;  Agata Leo?ska-Duniec, dr, Krzysztof Ficek, dr n.med.; Journal of Sports Medicine and Physical Fitness. The −174 G/C polymorphism of the IL6 gene is associated with elite power performance. 2013, 53(1), 88-92.
  23. Nir Eynon, prof., Emiliya Nasibulina, dr, Lauren Banting, dr, Pawe? Jan Ci?szczyk, dr hab., Agnieszka Maciejewska-Karlowska, dr, Marek Sawczuk, dr, Elvira Bondareva, dr, Roza Shagimardanova, dr, Maytal Raz, dr, Yael Sharon, dr, Alun Williams, dr, Ildus Ahmetov, dr, Alejandro Lucia, prof., Ruth Birk, dr;  PLoS One. The FTO A/T Polymorphism and Elite Athletic Performance: A Study Involving Three Groups of European Athletes. 2013, 8(4): e60570. DOI:10.1371/journal.pone.0060570.
  24. Marek Sawczuk, dr, Agnieszka Maciejewska-Kar?owska, dr, Pawe? Jan Ci?szczyk, dr hab., Bogumi?a Skotarczak, prof., Krzysztof Ficek, dr n.med.; Journal of Sports Sciences. Association of the ADRB2 Glu16Arg and Glu27Gln polymorphisms with athlete status.  DOI:dx.doi.org/10.1080/02640414.2013.786184.
  25. Jerzy Eider, dr hab., Agata Leo?ska-Duniec, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr,  Krzysztof Ficek, dr n.med., Stanis?aw Sawczyn, dr hab., Pawe? Jan Ci?szczyk, dr hab.; International SportMed Journal. The VEGFR2 gene His4 polymorphism in Polish endurance athletes. 2013, 14(1), 29
  26. Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr, Pawe? Jan Ci?szczyk, dr hab., Aleksandra Zar?bska, dr, Stanis?aw Sawczyn, dr hab.; PLoS One. Association between the Pro12Ala polymorphism of the Peroxisome Proliferator-Activated Receptor gamma gene and strength athlete status. 2013, 8(6), e67172. DOI:10.1371/journal.pone.0067172.
  27. Agnieszka Maciejewska-Karlowska, dr,  Eric Hanson, dr, Marek Sawczuk, dr, Pawe? Jan Ci?szczyk, dr hab., Nir Eynon, prof.; Scandinavian Journal of Medicine and Science in Sports. Genomic haplotype within the Peroxisome Proliferator-Activated Receptor Delta (PPARD) gene is associated with elite athletic status. DOI: 10.1111/sms.12126.
  28. Olga Fedotovskaya, dr, Jerzy Eider, dr hab., Pawe? Jan Ci?szczyk, dr hab., Ildus Ahmetov, dr, Waldemar Moska, prof., Stanis?aw Sawczyn, dr hab., Krzysztof Ficek, dr n.med., Agata Leo?ska-Duniec, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr, Zbigniew Czubek, dr, Ma?gorzata ?ychowska, dr, Nijole Jascaniene, dr hab.; Archives of Budo. Association of muscle-specific creatine kinase (CKM) gene polymorphism with combat athlete status in Polish and Russian cohorts. 2013, 9(3), 233-237.
  29. Guan Wang, prof., Sandosh Padmanabhan, prof., Bernard Wolfarth, prof. n. med., Noriyuki Fuku, prof., Alejandro Lucia, prof., Ildus Ahmetov, prof., Pawe? Cieszczyk, dr hab., Malcolm Collins, prof., Nir  Eynon, prof., Vassilis Klissouras, dr., Alun Williams, dr., Yannis Pitsiladis, prof.: Advances in Genetics. Genomics of elite sporting performance: What little we know and necessary advances.  2013, 84C, 123-149.
  30. Krzysztof Ficek, dr n.med., Pawe? Ci?szczyk, dr hab., Mariusz Kaczmarczyk, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk,, dr, Jerzy Cholewi?ski, dr, Agata Leo?ska-Duniec, dr, Marta St?pie?-S?odkowska, dr, Aleksandra Zar?bska, dr, Noil Stepto, dr, David Bishop, prof., Nir Eynon, prof.; Journal of Science and Medicine in Sports. Gene variants within the COL1A1 gene are associated with reduced anterior cruciate ligament injury in professional soccer players. 2013, 16, 396–400
  31. Aleksandra Zar?bska, dr, Stanis?aw Sawczyn, dr hab., Krzysztof Ficek, dr n.med., Mariusz Kaczmarczyk, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr, Agata Leo?ska-Duniec, dr, Jerzy Eider, dr hab., Agata Grenda, mgr, Pawe? Jan Ci?szczyk, dr hab.; Journal of Strength & Conditioning Research. An association of the Met235Thr polymorphism in the AGT gene with power but not endurance status in Polish athletes. 2013, 27(10), 2898-2903
  32. Jerzy Eider, dr hab., Pawe? Jan Ci?szczyk, dr hab., Agata Leo?ska-Duniec, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr, Krzysztof Ficek, dr n.med.; Science&Sports. The association between D allele of the ACE gene and power performance in Polish elite athletes. 2013, 28, 325—330.
  33. Pawe? Jan Ci?szczyk, dr hab., Jerzy Eider, dr hab., Agata Leo?ska-Duniec, dr, Magdalena Ostanek, dr, Marek Sawczuk, dr, Agnieszka Maciejewska, dr, Krzysztof Ficek, dr n.med., Katarzyna Sygit, dr, Katarzyna Kotarska, dr; Journal of Sports Sciences. Distribution of the AMPD1 T34C polymorphism in polish power-orientated athletes. 2012, 30, 31-35
  34. Agnieszka Maciejewska, dr,   Marek Sawczuk, dr, Pawe? Jan Ci?szczyk, dr hab., Irina Mozhayskaya, dr, Ildus Ahmetov, dr; The PPARGC1A gene Gly482Ser in Polish and Russian athletes. Journal of Sports Sciences. 2012:30:101-113
  35. Agnieszka Maciejewska-Kar?owska, dr, Agata Leo?ska-Duniec, dr, Pawe? Jan Ci?szczyk, dr hab., Marek Sawczuk, dr, Krzysztof Ficek, dr n.med., Jerzy Eider, dr hab., Stanis?aw Sawczyn, dr hab.; Journal of Human Kinetics. The GABPB1 gene A/G polymorphism in Polish rowers. 2012,31,59-62
  36. Pawe? Jan Ci?szczyk, dr hab., Michael Kalinski, prof., Magdalena Ostanek, dr, Nijole Jascaniene, dr hab., Krzysztof Krupecki, dr, Agnieszka Maciejewska, dr, Marek Sawczuk, dr, Krzysztof Ficek, dr n.med.; Journal of Strength & Conditioning Research. Variation in the HIF1α gene in Polish rowers. Published Ahead-of-Print Articles.  2012, 26(12), 3270-3274.
  37. Pawe? Jan Ci?szczyk, dr hab., Marek Sawczuk, dr, Agnieszka Maciejewska-Karlowska, dr, Krzysztof Ficek, dr n.med.; Journal of Exercise Science and Fitness. The ACTN3 R577X Polymorphism in Top-level Polish Rowers. 2012, 10,12-15.
  38. Marek Sawczuk, dr, Agnieszka Maciejewska-Kar?owska, dr, Pawe? Jan Ci?szczyk, dr hab., Aleksandra Zar?bska, dr; Central European Journal of Biology. Polymorphisms in the ADRB1 gene and endurance performance. 2012, 5, 794-800.
  39. Nir Eynon, prof., Jonathan Ruiz, dr, Vladimir Pushkarev, dr, Pawe? Cieszczyk, dr hab., Agnieszka Maciejewska-Karlowska, dr, Marek Sawczuk, dr, David Dyatlov, dr, Evgeny  Lekontsev, dr, Leonid Kulikov, dr, Ruth Birk, dr, Pedro Femia, dr, David Bishop, prof, Alejandro Lucia, prof.; PLoS One. Overcoming the barrier of sample size: The ACTN3 R577X polymorphism across three groups of elite European athletes. 2012 7(8): e43132. doi:10.1371/journal.pone.0043132
  40. Agnieszka Maciejewska, dr, Marek Sawczuk, dr, Pawe? Ci?szczyk, dr hab.; Journal of Science and Medicine in Sport. Variation in the PPARα gene in Polish rowers. (j?zyk publikacji: angielski). 2011, 14(1), 58-64.

  1. Pawe? Ci?szczyk, dr hab., Agnieszka Maciejewska, dr, Marek Sawczuk, dr, Krzysztof Ficek, dr n.med., Jerzy Eider, dr hab.; European Journal of Sport Science. The Variation Of Peroxisome Proliferator Activated Receptorα Gene In Elite Combat Athletes. 2011, 2, 119-123.
  2. Marek Sawczuk, dr, Agnieszka Maciejewska, dr, Pawe? Ci?szczyk, dr hab., Jerzy Eider, dr hab.; Science&Sports. The Role of Genetic Research in Sport. 2011, 26, 251-258.
  3. Pawe? Ci?szczyk, dr, Jerzy, Eider, dr hab., Magdalena Ostanek, dr, Aleksandra Arczewska, mgr, Agata Leo?ska-Duniec, dr, Stanis?aw Sawczyn, dr, Krzysztof Ficek, dr, Krzysztof Krupecki, dr; Journal of Human Kinetics. Association of the ACTN3 R577X polymorphism in Polish power-orientated athletes. 2011, 28, 5-11.

  1. Pawe? Ci?szczyk, dr, Jerzy, Eider, dr hab., Aleksandra Arczewska, mgr, Magdalena Ostanek, dr, Agata Leo?ska-Duniec, dr, Stanis?aw Sawczyn, dr, Krzysztof Ficek, Nijole Jascaniene, dr hab., Katarzyna Kotarska, dr, Katarzyna Sygit, dr; Biology of Sport. The HIF1A gene Pro582Ser polymorphism in Polish power-orientated athletes. (j?zyk publikacji: angielski).2011, 28, 111-114.
  2. Pawe? Ci?szczyk, dr, Jerzy, Eider, dr hab., Magdalena Ostanek, dr, Agata Leo?ska-Duniec, dr, Krzysztof Ficek, Katarzyna Kotarska, dr; International Journal of Sports Medicine. Is the C34T Polymorphism of the AMPD1 gene Associated with Athlete Performance in Rowing. 2011, 32(12), 987-991. (Impact Factor=2,4; 27 pkt. MNiSW).
  3. Krzysztof Ficek, dr, Tomasz Kami?ski, dr, Ewa Wach, dr, Jerzy Cholewi?ski, dr, Pawe? Ci?szczyk, dr; Journal of Human Kinetics. Application of platelet rich plasma in sports medicine. 2011, 30, 79-91.
  4. Pawe? Ci?szczyk, dr hab., Agnieszka Maciejewska, dr, Marek Sawczuk, dr, Krzysztof Ficek, dr n.med., Jerzy Eider, dr hab., Nijole Jascaniene, prof.; Biology of Sport. The Angiotensin Converting Enzyme Gene I/D Polymorphism in Ellite Polish and Lithuanian Judo Players.  2010,27(2),119-122.
  5. Pawe? Ci?szczyk, dr hab., Krzysztof Krupceki, dr, Agnieszka Maciejewska, dr, Marek Sawczuk, dr; International Journal of Sports Medicine. The Angiotensin Converting Enzyme Gene I/D Polymorphism in Polish Rowers. (j?zyk publikacji: angielski). 2009, 30, 624-627.
  6. Pawe? Ci?szczyk, dr hab., Agnieszka Maciejewska, dr, Marek Sawczuk, dr; Biology of Excercise. Gene doping in modern sport. 2009, 5.1, 5-14.
  7. Pawe? Ci?szczyk, dr hab., Agnieszka Maciejewska, dr, Marek Sawczuk, dr, Nijole Jascaniene, prof., Jerzy Eider, dr hab.; Journal of Human Kinetics. Do G894T Polymorphisms of Endothelial Nitric Oxide Synthase 3 (NOS3) Influence Endurance Phenotypes? 2010, 24,73-30
  8. Jerzy Eider, dr hab., Krzysztof Ficek, dr n.med., Mariusz Kaczmarczyk, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, drPawe? Jan Ci?szczyk, dr hab.; Central European Journal of Biology. Endothelial Nitric Oxide Synthase G894T (rs1799983) gene polymorphism in Polish athletes. 2014, 9(3), 260-267.
  9. Nir Eynon, prof., Lauren Banting, dr, Jonathan Ruiz, dr, Pawe? Jan Ci?szczyk, dr hab. Dmitry Dyatlov, dr, Agnieszka Maciejewska-Karlowska, dr, Marek Sawczuk, dr, Vladimir Pushkarev, dr, Leonid Kulikov, dr, Evgeny Pushkarev, dr, Pedro Femia, dr, Noil Stepto, dr, David Bishop, prof., Alejandro Lucia, prof.; Journal of Science and Medicine in Sport. ACTN3 R577X polymorphism and team-sport performance: A study involving three European cohorts. 2014, 17(14), 102–106.
  10. Marek Sawczuk, dr, Agnieszka Maciejewska-Kar?owska, dr, Agata Leo?ska-Duniec, drPawe? Jan Ci?szczyk, dr hab.; Biology of Sport. Is GNB3 C825T polymorphism associated with elite status of Polish athletes?  2014, 31:21-25.
  11. Marek Sawczuk, dr, Lauren Banting ,dr, Pawe? Ci?szczyk, dr hab., Agnieszka Maciejewska-Karlowska, dr, Aleksandra Zar?bska, dr, Agata Leo?ska-Duniec, dr, Zbigniew Jastrz?bski, dr hab., David Bishop, prof., Nir Eynon, dr; Journal of Science and Medicine in Sports. MCT1 A1470T:  a novel polymorphism for sprint performance? DOI : http://dx.doi.org/10.1016/j.jsams.2013.12.008
  12. Zi-Hong He, dr, Yang Hu, dr, Yan-Chun Li, dr, Li-Jing Gong, dr, Pawel Jan Cieszczyk, dr hab., Agnieszka Maciejewska-Karlowska, dr hab., Agata Leonska-Duniec, dr,Carlos Muniesa, dr, Maria Marín-Peiro, dr, Catalina Santiago, dr, Nuria Garatachea, dr, Nir Eynon, prof., Alejandro Lucia, prof.; Scandinavian Journal of Medicine & Science in Sports. PGC-related gene variants and elite endurance athletic status in a Chinese cohort: a functional study. 2014, DOI: 10.1111/sms.12188..
  13. Chamera Tomasz, dr, Spieszny Micha?, dr hab, Klocek Tomasz, dr, Kostrzewa-Nowak Dorota, dr, Nowak Robert, dr, Lachowicz Milena, dr, Buryta Rafa?, mgr, Ci?szczyk Pawe?, dr hab.; Journal of Strength and Conditioning Research. Could biochemical liver profile help to assess metabolic response to aerobic effort in athletes? DOI: 10.1519/JSC.0000000000000398)
  14. Chamera Tomasz, dr, Spieszny Micha?, dr hab, Klocek Tomasz, dr, Kostrzewa-Nowak Dorota, dr, Nowak Robert, dr, Lachowicz Milena, dr, Buryta Rafa?, mgr, Eider Jerzy, dr hab., Moska Waldemar, dr hab., Ci?szczyk Pawe?, dr hab.; Journal of Medical Biochemistry. Post-effort changes in activity of traditional diagnostic enzymatic markers in football players’ blood. DOI: 10.2478/jomb-2014-0035).
  15. Agata Grenda, mgr, Agata Leo?ska-Duniec, drPawe? Jan Ci?szczyk, dr hab., Piotr ?mijewski, dr; Biology of Sport. BDKRB2 gene -9/+9 polymorphism and swimming performance  2014, 31:109-113.
  16. Sarath Voisin, dr, Pawe? Cieszczyk, dr hab., Vladimir Pushkarev, dr, Dmitry Dyatlov, dr, Boris Vashlyayev, dr, Vladimir Shumaylov, dr, Agnieszka Maciejewska-Karlowska, dr, Marek Sawczuk, dr, Lidia Skuza, dr, Zbigniew Jastrzebski, dr hab, Bishop David, prof., Eynon Nir, dr; BMC Genomics. Interaction between gene variants in the EPSA1 gene and their impact on elite athletic performance in two cohorts of European athletes. 2014, 15:382  doi:10.1186/1471-2164-15-382
  17. Ildus Ahmetov, prof., Vladimir Naumov, dr, Andrey Donnikov, dr, Agnieszka Maciejewska-Kar?owska, dr, Elena Kostryukova, dr, Andrey Larin, dr, Evgeniya Maykova, dr,  Dmitry Alexeev, dr, Olga Fedotovskaya, dr, Edward Generozov, dr, Zbigniew Jastrz?bski, dr hab., Piotr ?mijewski, dr, Olga Kravtsova, dr, Nickolay Kulemin, dr, Agata Leonska-Duniec, dr, Dilyara Martykanova, dr, Elena Ospanova, dr, Alexander Pavlenko, dr, Alla  Podolskaya, dr, Marek Sawczuk, dr, Farida Alimova, dr, Dmitry Trofimov, dr, Vadim Govorun, dr, Pawel Cieszczyk, dr hab.; Free Radical Research. The SOD2 gene polymorphism and muscle damage markers in elite athletes. doi: 10.3109/10715762.2014.928410
  18. Leysan Mustafina, dr, Vladimir Naumov, dr, Pawel Cieszczyk, dr hab., Daniil Popov, prof., Ekaterina Lyubaeva, dr, Elena Kostryukova, dr, Olga Fedotovskaya, dr, Anastasiya  Druzhevskaya, dr, Irina Astratenkova, dr, Andrey Glotov, dr, Dmitry Alexeev, dr, Milyausha Mustafina, dr, Emiliya Egorova, dr, Agnieszka Maciejewska-Kar?owska, dr, Andrey Larin, dr, Edward Generozov, dr, Ruslan Nurullin, dr, Zbigniew Jastrz?bski, dr hab., Nickolay Kulemin, dr, Elena Ospanova, dr, Alexander Pavlenko, dr, Marek Sawczuk, dr, Egor Akimov, dr, Anna Danilushkina, dr, Piotr ?mijewski, dr, Olga Vinogradova, dr, Vadim Govorun, dr, Ildus Ahmetov, prof.; Experimental Physiology. The AGTR2 gene polymorphism is associated with muscle fibre composition, athlete status and aerobic performance. DOI.10.1113/expphysiol.2014.079335 
  19. Kevin O’Connell, dr, Hayley Knight, dr, Krzysztof Ficek, dr, Agata Leonska-Duniec, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr, Marta Stepien-Slodkowska, dr, Deon O’Cuinneagain, dr, Willem Van Der Merwe, dr, Michael Posthumus, dr, Pawel Cieszczyk, dr hab., Malcolm Collins, prof.; European Journal of Sport Science. Interactions between collagen gene variants and risk of anterior cruciate ligament rupture. DOI http://dx.doi.org/10.1080/17461391.2014.936324.
  20. Krzysztof Ficek, dr, Marta St?pie?- S?odkowska, dr, Mariusz Kaczmarczyk, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr, Jerzy Cholewi?ski, dr, Agata Leo?ska-Duniec, dr, Aleksandra Zar?bska, dr, Pawe? Ci?szczyk, dr hab., Piotr ?mijewski, dr; Balkan Journal of Medical Genetics. Does the A9285G polymorphism in the collagen type XII alpha-1 gene associate with the risk of anterior cruciate ligament ruptures? 2014, 17 (1): 1-6, DOI: 10.2478/bjmg-2014-0022.
  21. Aleksandra Zar?bska, dr, Zbigniew Jastrz?bski, dr, Mariusz Kaczmarczyk, dr, Krzysztof Ficek, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr, Agata Leo?ska-Duniec, dr, Pawe? Król, dr, Pawe? Ci?szczyk, dr hab., Piotr ?mijewski, dr, Nir Eynon, prof.; Biology of Sport. The rs1695 (c.313A>G) polymorphism in the GSTP1 gene modulates VO2max improvements in response to aerobic dance training. 2014,31:261-266
  22. Agata Grenda, mgr, Agata Leo?ska-Duniec, dr, Mariusz Kaczmarczyk, dr, Krzysztof Ficek, dr, Pawe? Król, dr, Pawe? Ci?szczyk, dr hab., Piotr ?mijewski, dr; Journal of Human Kinetics. Genetic Variation of ACE and ACTN3 in Elite Polish Swimmers. 2014,42:127-135.
  23. Aleksandra Zarebska, dr, Zbigniew Jastrzebski, dr hab. Pawe? Ci?szczyk, dr hab., Agata Leonska-Duniec, dr, Katarzyna Kotarska,dr, Mariusz Kaczmarczyk, dr, Marek Sawczuk, dr, Agnieszka Maciejewska-Karlowska, dr hab.; PPAR Research. The Pro12Ala polymorphism of the Peroxisome Proliferator-Activated Receptor gamma gene modify the association of physical activity and body mass changes in Polish women. DOI. 10.1155/2014/373782
  24. Orysiak Joanna, dr, Sitkowski Dariusz, dr, Zmijewski Piotr, dr,  Malczewska-Lenczowska Jadwiga, dr hab., Cieszczyk Pawe?, dr hab., Zembron-Lacny Agnieszka, dr hab., Pokrywka Andrzej, dr;. Journal of Strength and Conditioning Research. Overrepresentation of the ACTN3 XX genotype in elite canoe and kayak paddlers. DOI. 10.1519/JSC.0000000000000717
  25. Kostrzewa – Nowak Dorota, dr, Nowak Robert, dr, Chamera Tomasz, dr,  Buryta Rafa?, dr, Moska Waldemar, dr hab., Cieszczyk Pawe?, dr hab.; Journal of Strength and Conditioning Research. Post-effort chances in c-reactive protein level among soccer players at the end of the training season. doi: 10.1519/JSC.0000000000000753  
  26. Marek Sawczuk, dr, Yevgeniya I. Timshina, dr, Irina V. Astratenkova, dr, Agnieszka Maciejewska-Kar?owska, dr, Agata Leo?ska-Duniec, dr, Krzysztof Ficek, dr, Leysan J. Mustafina, dr, Pawe? Ci?szczyk, dr hab., Tomasz Klocek, dr, Ildus I. Ahmetov, prof; Human Biology. The –9/+9 Polymorphism of the Bradykinin Receptor Beta 2 Gene and Athlete Status: A Study Involving Two European Cohorts.). 2013, 85(4), 743-757.
  27. Aleksandra Zar?bska, dr, Ildus Ahmetov, dr, Stanis?aw Sawczyn, dr hab., Alexandra Weiner, dr, Mariusz Kaczmarczyk, dr, Krzysztof Ficek, dr n.med., Agnieszka Maciejewska-Karlowska, dr, Marek Sawczuk, dr, Agata Leo?ska-Duniec, dr, Tomasz Klocek, dr, Elena Voronina, dr, Uljana Boyarskikh, dr, Maksim Filipenko, dr, Pawe? Jan Ci?szczyk, dr hab.; Journal of Sports Sciences. Association of the MTHFR 1298A>C (rs1801131) polymorphism with speed and strength sports in Russian and Polish athletes. (DOI:10.1080/02640414.2013.825731.
  28. Marta St?pie?-S?odkowska, dr, Krzysztof Ficek, dr n.med., Jerzy Eider, dr hab., Agata Leo?ska-Duniec, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr, Aleksandra Zar?bska, dr, Zbigniew Jastrz?bski, prof., Agata Grenda, mgr, Katarzyna Kotraska, dr, Pawe? Jan Ci?szczyk, dr hab. Biology of Sport. The +1245G/T polymorphisms in the collagen type I alpha-1 (COL1A1) gene as one of genetic marker in Anterior Cruciate Ligament injury. 2013, 30, 57-60.
  29. Jerzy Eider, dr hab., Agnieszka Maciejewska, dr, Marek Sawczuk, dr, Pawe? Jan Ci?szczyk, dr hab., Magdalenia Ostanek, dr;  Agata Leo?ska-Duniec, dr, Krzysztof Ficek, dr n.med.; Journal of Sports Medicine and Physical Fitness. The −174 G/C polymorphism of the IL6 gene is associated with elite power performance. 2013, 53(1), 88-92.
  30. Nir Eynon, prof., Emiliya Nasibulina, dr, Lauren Banting, dr, Pawe? Jan Ci?szczyk, dr hab., Agnieszka Maciejewska-Karlowska, dr, Marek Sawczuk, dr, Elvira Bondareva, dr, Roza Shagimardanova, dr, Maytal Raz, dr, Yael Sharon, dr, Alun Williams, dr, Ildus Ahmetov, dr, Alejandro Lucia, prof., Ruth Birk, dr;  PLoS One. The FTO A/T Polymorphism and Elite Athletic Performance: A Study Involving Three Groups of European Athletes. 2013, 8(4): e60570. DOI:10.1371/journal.pone.0060570.
  31. Marek Sawczuk, dr, Agnieszka Maciejewska-Kar?owska, dr, Pawe? Jan Ci?szczyk, dr hab., Bogumi?a Skotarczak, prof., Krzysztof Ficek, dr n.med.; Journal of Sports Sciences. Association of the ADRB2 Glu16Arg and Glu27Gln polymorphisms with athlete status.  DOI:dx.doi.org/10.1080/02640414.2013.786184.
  32. Jerzy Eider, dr hab., Agata Leo?ska-Duniec, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr,  Krzysztof Ficek, dr n.med., Stanis?aw Sawczyn, dr hab., Pawe? Jan Ci?szczyk, dr hab.; International SportMed Journal. The VEGFR2 gene His4 polymorphism in Polish endurance athletes. 2013, 14(1), 29
  33. Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr, Pawe? Jan Ci?szczyk, dr hab., Aleksandra Zar?bska, dr, Stanis?aw Sawczyn, dr hab.; PLoS One. Association between the Pro12Ala polymorphism of the Peroxisome Proliferator-Activated Receptor gamma gene and strength athlete status. 2013, 8(6), e67172. DOI:10.1371/journal.pone.0067172.
  34. Agnieszka Maciejewska-Karlowska, dr,  Eric Hanson, dr, Marek Sawczuk, dr, Pawe? Jan Ci?szczyk, dr hab., Nir Eynon, prof.; Scandinavian Journal of Medicine and Science in Sports. Genomic haplotype within the Peroxisome Proliferator-Activated Receptor Delta (PPARD) gene is associated with elite athletic status. DOI: 10.1111/sms.12126.
  35. Olga Fedotovskaya, dr, Jerzy Eider, dr hab., Pawe? Jan Ci?szczyk, dr hab., Ildus Ahmetov, dr, Waldemar Moska, prof., Stanis?aw Sawczyn, dr hab., Krzysztof Ficek, dr n.med., Agata Leo?ska-Duniec, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr, Zbigniew Czubek, dr, Ma?gorzata ?ychowska, dr, Nijole Jascaniene, dr hab.; Archives of Budo. Association of muscle-specific creatine kinase (CKM) gene polymorphism with combat athlete status in Polish and Russian cohorts. 2013, 9(3), 233-237.
  36. Guan Wang, prof., Sandosh Padmanabhan, prof., Bernard Wolfarth, prof. n. med., Noriyuki Fuku, prof., Alejandro Lucia, prof., Ildus Ahmetov, prof., Pawe? Cieszczyk, dr hab., Malcolm Collins, prof., Nir  Eynon, prof., Vassilis Klissouras, dr., Alun Williams, dr., Yannis Pitsiladis, prof.: Advances in Genetics. Genomics of elite sporting performance: What little we know and necessary advances.  2013, 84C, 123-149.
  37. Krzysztof Ficek, dr n.med., Pawe? Ci?szczyk, dr hab., Mariusz Kaczmarczyk, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk,, dr, Jerzy Cholewi?ski, dr, Agata Leo?ska-Duniec, dr, Marta St?pie?-S?odkowska, dr, Aleksandra Zar?bska, dr, Noil Stepto, dr, David Bishop, prof., Nir Eynon, prof.; Journal of Science and Medicine in Sports. Gene variants within the COL1A1 gene are associated with reduced anterior cruciate ligament injury in professional soccer players. 2013, 16, 396–400
  38. Aleksandra Zar?bska, dr, Stanis?aw Sawczyn, dr hab., Krzysztof Ficek, dr n.med., Mariusz Kaczmarczyk, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr, Agata Leo?ska-Duniec, dr, Jerzy Eider, dr hab., Agata Grenda, mgr, Pawe? Jan Ci?szczyk, dr hab.; Journal of Strength & Conditioning Research. An association of the Met235Thr polymorphism in the AGT gene with power but not endurance status in Polish athletes. 2013, 27(10), 2898-2903
  39. Jerzy Eider, dr hab., Pawe? Jan Ci?szczyk, dr hab., Agata Leo?ska-Duniec, dr, Agnieszka Maciejewska-Kar?owska, dr, Marek Sawczuk, dr, Krzysztof Ficek, dr n.med.; Science&Sports. The association between D allele of the ACE gene and power performance in Polish elite athletes. 2013, 28, 325—330.
  40. Pawe? Jan Ci?szczyk, dr hab., Jerzy Eider, dr hab., Agata Leo?ska-Duniec, dr, Magdalena Ostanek, dr, Marek Sawczuk, dr, Agnieszka Maciejewska, dr, Krzysztof Ficek, dr n.med., Katarzyna Sygit, dr, Katarzyna Kotarska, dr; Journal of Sports Sciences. Distribution of the AMPD1 T34C polymorphism in polish power-orientated athletes. 2012, 30, 31-35
  41. Agnieszka Maciejewska, dr,   Marek Sawczuk, dr, Pawe? Jan Ci?szczyk, dr hab., Irina Mozhayskaya, dr, Ildus Ahmetov, dr; The PPARGC1A gene Gly482Ser in Polish and Russian athletes. Journal of Sports Sciences. 2012:30:101-113
  42. Agnieszka Maciejewska-Kar?owska, dr, Agata Leo?ska-Duniec, dr, Pawe? Jan Ci?szczyk, dr hab., Marek Sawczuk, dr, Krzysztof Ficek, dr n.med., Jerzy Eider, dr hab., Stanis?aw Sawczyn, dr hab.; Journal of Human Kinetics. The GABPB1 gene A/G polymorphism in Polish rowers. 2012,31,59-62
  43. Pawe? Jan Ci?szczyk, dr hab., Michael Kalinski, prof., Magdalena Ostanek, dr, Nijole Jascaniene, dr hab., Krzysztof Krupecki, dr, Agnieszka Maciejewska, dr, Marek Sawczuk, dr, Krzysztof Ficek, dr n.med.; Journal of Strength & Conditioning Research. Variation in the HIF1α gene in Polish rowers. Published Ahead-of-Print Articles.  2012, 26(12), 3270-3274.
  44. Pawe? Jan Ci?szczyk, dr hab., Marek Sawczuk, dr, Agnieszka Maciejewska-Karlowska, dr, Krzysztof Ficek, dr n.med.; Journal of Exercise Science and Fitness. The ACTN3 R577X Polymorphism in Top-level Polish Rowers. 2012, 10,12-15.
  45. Marek Sawczuk, dr, Agnieszka Maciejewska-Kar?owska, dr, Pawe? Jan Ci?szczyk, dr hab., Aleksandra Zar?bska, dr; Central European Journal of Biology. Polymorphisms in the ADRB1 gene and endurance performance. 2012, 5, 794-800.
  46. Nir Eynon, prof., Jonathan Ruiz, dr, Vladimir Pushkarev, dr, Pawe? Cieszczyk, dr hab., Agnieszka Maciejewska-Karlowska, dr, Marek Sawczuk, dr, David Dyatlov, dr, Evgeny  Lekontsev, dr, Leonid Kulikov, dr, Ruth Birk, dr, Pedro Femia, dr, David Bishop, prof, Alejandro Lucia, prof.; PLoS One. Overcoming the barrier of sample size: The ACTN3 R577X polymorphism across three groups of elite European athletes. 2012 7(8): e43132. doi:10.1371/journal.pone.0043132
  47. Agnieszka Maciejewska, dr, Marek Sawczuk, dr, Pawe? Ci?szczyk, dr hab.; Journal of Science and Medicine in Sport. Variation in the PPARα gene in Polish rowers. (j?zyk publikacji: angielski). 2011, 14(1), 58-64.

  48. Pawe? Ci?szczyk, dr hab., Agnieszka Maciejewska, dr, Marek Sawczuk, dr, Krzysztof Ficek, dr n.med., Jerzy Eider, dr hab.; European Journal of Sport Science. The Variation Of Peroxisome Proliferator Activated Receptorα Gene In Elite Combat Athletes. 2011, 2, 119-123.
  49. Marek Sawczuk, dr, Agnieszka Maciejewska, dr, Pawe? Ci?szczyk, dr hab., Jerzy Eider, dr hab.; Science&Sports. The Role of Genetic Research in Sport. 2011, 26, 251-258.
  50. Pawe? Ci?szczyk, dr, Jerzy, Eider, dr hab., Magdalena Ostanek, dr, Aleksandra Arczewska, mgr, Agata Leo?ska-Duniec, dr, Stanis?aw Sawczyn, dr, Krzysztof Ficek, dr, Krzysztof Krupecki, dr; Journal of Human Kinetics. Association of the ACTN3 R577X polymorphism in Polish power-orientated athletes. 2011, 28, 5-11.

  51. Pawe? Ci?szczyk, dr, Jerzy, Eider, dr hab., Aleksandra Arczewska, mgr, Magdalena Ostanek, dr, Agata Leo?ska-Duniec, dr, Stanis?aw Sawczyn, dr, Krzysztof Ficek, Nijole Jascaniene, dr hab., Katarzyna Kotarska, dr, Katarzyna Sygit, dr; Biology of Sport. The HIF1A gene Pro582Ser polymorphism in Polish power-orientated athletes. (j?zyk publikacji: angielski).2011, 28, 111-114.
  52. Pawe? Ci?szczyk, dr, Jerzy, Eider, dr hab., Magdalena Ostanek, dr, Agata Leo?ska-Duniec, dr, Krzysztof Ficek, Katarzyna Kotarska, dr; International Journal of Sports Medicine. Is the C34T Polymorphism of the AMPD1 gene Associated with Athlete Performance in Rowing. 2011, 32(12), 987-991. (Impact Factor=2,4; 27 pkt. MNiSW).
  53. Krzysztof Ficek, dr, Tomasz Kami?ski, dr, Ewa Wach, dr, Jerzy Cholewi?ski, dr, Pawe? Ci?szczyk, dr; Journal of Human Kinetics. Application of platelet rich plasma in sports medicine. 2011, 30, 79-91.
  54. Pawe? Ci?szczyk, dr hab., Agnieszka Maciejewska, dr, Marek Sawczuk, dr, Krzysztof Ficek, dr n.med., Jerzy Eider, dr hab., Nijole Jascaniene, prof.; Biology of Sport. The Angiotensin Converting Enzyme Gene I/D Polymorphism in Ellite Polish and Lithuanian Judo Players.  2010,27(2),119-122.
  55. Pawe? Ci?szczyk, dr hab., Krzysztof Krupceki, dr, Agnieszka Maciejewska, dr, Marek Sawczuk, dr; International Journal of Sports Medicine. The Angiotensin Converting Enzyme Gene I/D Polymorphism in Polish Rowers. (j?zyk publikacji: angielski). 2009, 30, 624-627.
  56. Pawe? Ci?szczyk, dr hab., Agnieszka Maciejewska, dr, Marek Sawczuk, dr; Biology of Excercise. Gene doping in modern sport. 2009, 5.1, 5-14.
  57. Pawe? Ci?szczyk, dr hab., Agnieszka Maciejewska, dr, Marek Sawczuk, dr, Nijole Jascaniene, prof., Jerzy Eider, dr hab.; Journal of Human Kinetics. Do G894T Polymorphisms of Endothelial Nitric Oxide Synthase 3 (NOS3) Influence Endurance Phenotypes? 2010, 24,73-30
Scientific Activities

Topic editor in Central European Journal of Sport Sciences and Medicine

Member of Editor Board of Biology of Excercise, Sport Sciences, Biology of Sport